Clinical trials: Geriatric Cancer Patients
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Follicular Lymphoma
Brief Chemoimmunotherapy With R+B+M Followed by R in Elderly Patients Advanced Stage Untreated Follicular Lymphoma
This is a prospective, multicenter phase II trial designed to determine efficacy and safety of a brief chemoimmunotherapy with the combination of Rituximab + Bendamustine + Mitoxantrone in elderly patients with advanced stage…
- Trial name
- FLE09 (NCT01523860)
- Testing
- Rituximab, Mitoxantrone, Bendamustine
- Where
- 37 sites in Italy
- Volunteers
- 76 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Philadelphia Positive Acute Lymphoblastic Leukemia, Lymphoid Blastic Phase of Chronic Myeloid Leukemia
Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL)
The aims of the study are to determine whether single agent imatinib (STI571; Glivec) is more effective as up-front remission induction therapy than conventional multi-agent induction chemotherapy for elderly patients with…
- Trial name
- NCT00199186
- Testing
- imatinib, vincristine, cyclophosphamide
- Where
- Germany
- Sponsor
- Johann Wolfgang Goethe University Hospital
Breast Cancer, Gastrointestinal Cancer
A Feasibility Trial of Geriatric Assessment and Management for Older Cancer Patients
The purpose of this study is to determine the feasibility of implementing a randomized controlled study of the intervention (Geriatric Assessment followed by an integrated care plan carried out by the multidisciplinary geriatric…
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- NCT02222259
- Testing
- GA and Integrated Care Plan
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Adult Acute Lymphocytic Leukemia
German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
The study evaluates the efficacy and tolerability of a dose-reduced chemotherapy for the treatment of elderly patients with acute lymphoblastic leukemia.
- Trial name
- NCT00198978
- Testing
- Cyclophosphamide, Dexamethasone / Prednisolone, Cytarabine
- Where
- Germany
- Volunteers
- 377 people
- Sponsor
- Goethe University
Postoperative Delirium (POD), Gynecologic Cancers
Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology
Early postoperative delirium (POD) is a common and distressing neuropsychiatric complication frequently observed in elderly patients undergoing major surgical interventions, including radical and cytoreductive gynecologic…
- Conditions
- Postoperative Delirium (POD), Gynecologic Cancers, Malnutitrion
- Trial name
- NCT07877285
- Testing
- Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Head and Neck Cancer Squamous Cell Carcinoma, ELDERLY PEOPLE
Hypofractionated Radiotherapy for HNSCC in Elderly Patients
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor, with 25% of HNSCC patients diagnosed at over 70 years of age. As the population ages, it is expected that by 2030, this proportion will exceed 60%.
- Conditions
- Head and Neck Cancer Squamous Cell Carcinoma, ELDERLY PEOPLE, Hypofractionation
- Trial name
- HNSCC (NCT06768125)
- Testing
- Hypofractionated Radiation Therapy
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Unresectable Colorectal Cancer, Advanced Malignancy
Clinical Efficacy of Transarterial Chemoembolization in Elderly Patients With Advanced Unresectable Colorectal Cancer
We plan to conduct a prospective, two-arm, open-label phase Ⅱ study to evaluate whether transarterial chemoembolization with FOLFOX plus/minus intravenous cetuximab/bevacizumab significantly improves the efficacy and safety…
- Conditions
- Unresectable Colorectal Cancer, Advanced Malignancy, Elderly (People Aged 65 or More)
- Trial name
- NCT07209384
- Testing
- Transarterial chemoembolization
- Volunteers
- 50 people
- Sponsor
- Junpeng Wang
Hematologic Malignancy, Old Age; Debility
Nutritional and Physical Exercise Intervention in Older Patients With Malignant Hemopathies
Clinical trial to analyze the impact of nutrition and physical exercise intervention program on the completion of treatment in older patients 70 years or older with malignant hemopathology
- Trial name
- ICOSENIORHEM (NCT04057443)
- Testing
- Nutritional support, Physical exercise, Hematologic Drug
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Maite Antonio, MD, Phd
Diffuse Large B-Cell Lymphoma
Bendamustine, Obinutuzumab, and Dexamethasone in Older Patients With Diffuse Large B-cell Lymphoma
This phase II trial studies how well bendamustine hydrochloride, obinutuzumab, and dexamethasone work in treating older patients with diffuse large B-cell lymphoma.
- Trial name
- NCT02420210
- Testing
- Bendamustine Hydrochloride, Obinutuzumab, Dexamethasone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Chicago
Acute Myeloid Leukemia
Venetoclax+HMA+Aclarubicin Versus Venetoclax+HMA in Treatment-Naive Elderly Patients With AML
This research is being done to assess the therapeutic efficacy and safety of a promising regimen (Venetoclax combined with Decitabine/Azacitidine and Aclarubicin) versus Venetoclax combined with Decitabine/Azacitidine in…
- Trial name
- NCT05264883
- Testing
- Venetoclax-Decitabine/Azacitidine-Aclarubicin Association, Venetoclax-Decitabine/Azacitidine Association
- Where
- China
- Volunteers
- 170 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Myeloid Leukemia
HCT Versus CT in Elderly AML
A study comparing conventional chemotherapy to low dose total body irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors as consolidation therapy for older Patients with AML in…
- Trial name
- NCT00766779
- Testing
- hematopoietic cell transplantation, Non-Transplant treatment approach for consolidation
- Where
- 48 sites in Australia, Austria and 5 more
- Volunteers
- 126 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Lung Cancer
Robotic Assisted Major Lung Resection in Elderly Patients
The study is a retrospective observational study. The study is designed to be multicentric and it will analyze medical records from selected patients that underwent major lung resection using DaVinci surgical platform performed…
- Trial name
- ELDERLY (NCT06496386)
- Where
- 2 sites in Italy
- Volunteers
- 386 people
- Sponsor
- Scientific Institute San Raffaele
Complications
Laparoscopy-assisted and Open Distal Gastrectomy for Gastric Cancer in the Elderly Patients
Laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer (EGC) has been supported by high-quality evidence, and the high-level evidence for advanced gastric cancer based on large prospective randomized…
- Trial name
- NCT02246153
- Testing
- Laparoscopic gastrectomy, Open gastrectomy
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Myeloid Leukemia
Decitabine Combined With Unrelated Cord Blood Transplantation for Elderly Patients With AML
Acute myeloid leukemia (AML) is a clonal disease caused by genetic mutations in Hematopoietic stem progenitor cells. Unfortunately, advanced age (>60 years old) is considered to be one of the most important adverse prognostic…
- Trial name
- NCT03913312
- Testing
- Unrelated cord blood
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Diffuse Large B-Cell Lymphoma
CHiR Therapy for Elderly DLBCL Intolerant to Chemo
The objective of exploring the application of CHiR is to evaluate its therapeutic efficacy and safety in newly diagnosed elderly patients with diffuse large B-cell lymphoma (DLBCL) aged 70 and above, and to investigate the…
- Trial name
- NCT06764017
- Testing
- CHiR-DEL
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Prostatic Neoplasms
Aggressive Prostate Cancers in Elderly Patients
Patients aged 70 years or older had a higher possibility of high risk cancer than younger patients.
- Trial name
- NCT01347476
- Where
- South Korea
- Volunteers
- 1,333 people
- Sponsor
- Seoul National University Hospital
Lymphoma, Mantle-Cell
Rituximab, Bendamustine and Cytarabine Followed by Venetoclax in High Risk Elderly Patients With MCL
Prospective, multicenter, phase II trial designed to evaluate whether the addition of Venetoclax after rituximab, bendamustine and cytarabine (R-BAC) to high risk patients with mantle cell lymphoma improves the results of the…
- Trial name
- NCT03567876
- Testing
- Venetoclax
- Where
- 35 sites in Italy
- Volunteers
- 141 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Non-Small-Cell Lung Cancer
Anlotinib Hydrochloride as Second-line Therapy in Elderly Patients With EGFR Wild-type Lung Adenocarcinoma
Anlotinib is a multi-target receptor tyrosine kinase inhibitor in domestic research and development. It can inhibit the angiogenesis related kinase, such as VEGFR, FGFR, PDGFR, and tumor cell proliferation related kinase -c-Kit…
- Trial name
- NCT03728374
- Testing
- Anlotinib
- Volunteers
- 38 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Impaired Cognition, Quality of Life
The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery
The primary aim of this study is to establish if it is possible for patients who have undergone major body surgery to complete a home based exercise training program and complete the assessments required to measure physical and…
- Conditions
- Impaired Cognition, Quality of Life, Surgery, Delirium
- Trial name
- POETold (NCT03064308)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
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