Clinical trials: Geriatric Disorder
Postoperative Complications, Delirium
Donepezil in Preventing Delirium in Hospitalized Elderly
The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.
- Trial name
- NCT00182884
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University Health
Influenza
Phase I Clinical Trial of Influenza Vaccine (Split Virion), Inactivated (High Dose)
This is a randomized, double-blind, active-controlled Phase I clinical trial to evaluate the safety and immunogenicity of Influenza Vaccine (Split Virion), Inactivated (High Dose) developed by Sinovac.
- Trial name
- NCT07737106
- Testing
- Influenza Vaccine (Split Virion), Inactivated (High Dose), Influenza Vaccine (Split Virion), Inactivated
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Meningococcal Disease, Meningococcal Meningitis
Safety and Immunogenicity of Novartis Meningococcal B Vaccine Formulated With OMV Manufactured at Two Different Sites, in Healthy Adolescents Aged 11-17 Years
The primary objective of this study is to demonstrate the equivalence of rMenB+OMV NZ lot 1 to rMenB+OMV NZ lot 2 when administered to adolescents, as measured by human serum bactericidal activity (hSBA) geometric mean titers…
- Trial name
- NCT01423084
- Testing
- Serogroup B meningococcal vaccine
- Where
- 13 sites in Australia, Canada
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Novartis
SARS-CoV-2 Infection
Clinical Study of the Third Dose Immunization Schedule of COVID-19 Inactivated Vaccine, (Vero Cells) in Adults Aged 18 Years and Above (6 Months After Two Doses)
To evaluate the immunogenicity and safety of the third dose SARS-CoV-2 Vaccine, Inactivated (Vero Cell) in adults aged 18 years and above, who inoculated the third dose after 6 months since finished two doses schedule of…
- Trial name
- NCT05216484
- Testing
- SARS-CoV-2 Vaccine, Inactivated (Vero Cell)
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Intestinal Schistosomiasis
Schistosoma Mansoni Morbidity in Children Aged 1-5 Years
This study is about intestinal schistosomiasis, commonly known as bilharzia, in children aged 1-5 years along Lake Victoria shoreline.The children will be screened for S.
- Trial name
- NCT01901484
- Testing
- Praziquantel
- Where
- Uganda
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Makerere University
Chronic Diseases
Evaluate the Effectiveness of a Virtual Community of Practice
Objective: To evaluate and compare the effectiveness and cost-effectiveness of a Virtual Community of Practice (VCoP) via a web-based application versus individual and self-administered online education to improve the activation…
- Trial name
- NCT06046326
- Testing
- virtual community of practice
- Where
- 3 sites in Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
Insomnia
Study to Investigate the Effects of Melatonin, Temazepam & Zolpidem on Sleep EEG in Men and Women
This study has been designed to compare the effects of melatonin with those of drugs (temazepam and zolpidem) regularly prescribed for the treatment of insomnia, in healthy, middle-aged volunteers.
- Trial name
- NCT00940550
- Testing
- Prolonged-release melatonin, Temazepam, Zolpidem
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Child Malnutrition
Growth and Nutritional Impact of Small Fish Powder Supplementation in Infants
This randomized controlled trial evaluated the effectiveness of supplementing the diets of infants aged 6-7 months with small fish powder on growth outcomes in the Garoua 1st Health District, Northern Cameroon.
- Trial name
- NCT07794085
- Testing
- Small Fish Powder, Millet Flour
- Where
- Cameroon
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre for Food and Nutrition Research, Yaounde
Influenza
Trivalent rHA Dose Escalation Study in Elderly Subjects
This study will compare the safety and immunogenicity of three different dose levels of an experimental recombinant influenza HA protein vaccine to a standard inactivated influenza vaccine in heallthy elderly subjects ages 65-80.
- Trial name
- NCT00170443
- Testing
- rHAO Trivalent Influenza Vaccine
- Where
- 3 sites in United States
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Herpes Zoster, Vaccine-Preventable Diseases
A Study to Evaluate Safety and Tolerability of a Recombinant Herpes Zoster Vaccine
This clinical trial is to study the safety and tolerability of a recombinant herpes zoster vaccine (LZ901) and sponsored by Beijing Luzhu Biotechnology Co., Ltd.
- Trial name
- NCT05750017
- Testing
- Low Dose Recombinant Herpes Zoster Vaccine (LZ901), High Dose Recombinant Herpes Zoster Vaccine (LZ901)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Beijing Luzhu Biotechnology Co., Ltd.
Influenza
Safety Study of an Adjuvanted Candidate Influenza Vaccine to Prevent Influenza Disease in the Elderly Population
As influenza vaccine efficacy is reported to be lower in elderly subjects compared to healthy adults, probably as a result of immunosenescence, there is a desire to devise ways to increase the current vaccines efficacy for this…
- Trial name
- NCT00318058
- Testing
- influenza vaccine Fluarix, Adjuvanted Fluarix
- Where
- Belgium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Varicella-zoster Virus
Phase II Clinical Trial of Lyophilized Herpes Zoster mRNA Vaccine in Adults Aged 40 Years or Above
The primary objective of this study is to evaluate the immunogenicity and safety of 2 injections (approximately 2 months apart) of ABO1108 in adults aged 40 years or above.
- Trial name
- NCT07285278
- Testing
- ABO1108
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Suzhou Abogen Biosciences Co., Ltd.
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pneumococcal Pneumonia, Pneumonia, Bacterial
Phase I to Test a New Pneumococcal Vaccine
To obtain first-in-human data on a new candidate vaccine against Streptococcus pneumoniae in healthy adult and elderly volunteers.
- Trial name
- NCT03303976
- Testing
- Bioconjugate pneumococcal vaccine, Multivalent plain polysaccharide vaccine
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Cardiovascular Risk Factor
Prognosis in the Elderly Chinese: the Northern Shanghai Study
The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and…
- Trial name
- NSS (NCT02368938)
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Human Papillomavirus Infection
A Study to Evaluate the Immunogenicity and Safety of HPV Vaccine in Healthy Female Participants Aged 9-26 Years in China
The study is to evaluate immune response induced by 9-valent HPV study vaccine is non-inferior to those induced by GARDASIL® 9 administrated with 3-dose schedule in female participants aged 20-26 years in China, if the immune…
- Trial name
- NCT05662020
- Testing
- Recombinant Nonavalent (types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia coli), GARDASIL® 9
- Where
- China
- Volunteers
- 2,750 people, healthy volunteers welcome
- Sponsor
- Beijing Health Guard Biotechnology, Inc
Vitamin D Deficiency, Metabolic Syndrome
Vitamin D Supplementation and Metabolism in Vitamin D Deficient Elderly
The purpose of this study is to examine the effects of Vitamin D supplementation on the reasons (mechanisms) underlying the development of type 2 diabetes, metabolic syndrome (high blood pressure, cholesterol, diabetes, body…
- Trial name
- VitD (NCT01145703)
- Testing
- RDA Vitamin D3 only, Vitamin D2/3 Repletion only, Vitamin D2/3 Repletion + AEX
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Osteoporosis, Sarcopenia
The Effect of 6 Months of Local Vibration Training in Institutionalized Elderly
This randomized controlled intervention study in institutionalized elderly investigates the effect of 6 months of local vibration therapy applied on the thigh and hip on muscle strength, muscle mass, bone density, and…
- Trial name
- NCT01499186
- Testing
- Local Vibration
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mild Cognitive Impairment, Randomized Controlled Trial
Cognitive Stimulation in Older With Mild Cognitive Impairment
The participants who carry out our program of cognitive stimulation, deteriorate at a cognitive level more slowly and can improve their score of the Spanish version of 35 points of Mini-mental State of Folstein; Mini-exam…
- Trial name
- Cognitive (NCT03831061)
- Testing
- Cognitive stimulation
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Community-acquired Pneumonia (CAP)
TCM Cohort for Elderly CAP
This study evaluates the real-world clinical efficacy of traditional Chinese medicine (TCM) in elderly Community-acquired pneumonia (CAP) patients and explores syndrome characteristics and their associations with biomarkers.
- Trial name
- NCT07797686
- Testing
- Traditional Chinese medicine (TCM), Non-traditional Chinese medicine (non-TCM)
- Where
- China
- Volunteers
- 2,234 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
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