Clinical trials: Geriatric Disorder
Diabetes Mellitus, Diabetic Peripheral Neuropathy
Neuropathic Pain in Elderly People With Diabetes: Impact on Quality of Life and Cognition
This study was set out 1) Evaluate the impact of Diabetic Peripheral Neuropathy (DPN) and DPN-P (Diabetic Peripheral Neuropathic Pain) on the overall Quality of Life (QoL) in elderly with Diabetic Mellitus (DM) and 2) Evaluate…
- Conditions
- Diabetes Mellitus, Diabetic Peripheral Neuropathy, Cognitive Impairment, Quality of Life
- Trial name
- NCT03909841
- Testing
- Cambridge Neuropsychological Test Automated Battery (CANTAB), Chinese (Hong Kong) 12-item Short-Form Health Survey (version 2)
- Where
- Hong Kong
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Dysphagia, Oropharyngeal
The Efficacy of Tongue Exercises on Swallowing Function in the Elderly With Mild Cognitive Impairment
The purpose of this study is to explore the effects of tongue muscle strength and resistance exercises on dysphagia, tongue muscle strength, oral hygiene, repetitive saliva swallowing, nutrition, depression, and…
- Trial name
- NCT06490705
- Testing
- tongue resistance exercises, tongue strengthening exercises and tongue resistance exercises
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation
Hepatitis E
Phase Ⅳ Clinical Trial of Recombinant Hepatitis E Vaccine（Hecolin®）
The purpose of this study is to determine the safety and immunogenicity of the recombinant hepatitis E vaccine in people older than 65 years, and evaluate the efficacy of hepatitis E vaccine in this population.
- Trial name
- NCT02189603
- Testing
- Recombinant (E. Coli) Hepatitis E Vaccine
- Where
- China
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- Jun Zhang
Elderly People Institutionalized in Long-term Care Services
Humoral and Cellular Responses to Vaccination Against Coronavirus Disease 2019 (COVID-19) in the Very Elderly Living in Geriatric Institutions
The main objective of this study is to describe the humoral and cellular response to BNT162b2 vaccination in people over age 75 institutionalized in the long-term care units of the Paris Public Hospitals (APHP)
- Trial name
- COGEVAX-BIO (NCT04961502)
- Testing
- Blood test to describe the humoral and cellular response to vaccination BNT162b2 in the elderly
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gérond'if
Herpes Zoster
Safety and Immunogenicity Study of Live Attenuated Vaccine Against Herpes Zoster in Chinese Adults Aged 50 Years and Older
This study evaluates the safety and immunogenicity of live attenuated vaccine in adults aged 50 years and older. Half of participants will receive high doses of the vaccine,while the other half will receive low doses of the…
- Trial name
- NCT02526745
- Testing
- the vaccine with high doses of virus content between 4.7～5.0 lgPFU, the vaccine with low doses of virus content between 4.7～5.0 lgPFU, the vaccine with high doses of virus content between 4.3～5.0 lgPFU
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Beijing Chaoyang District Centre for Disease Control and Prevention
Alzheimer Disease, Healthy Aging
Telerehabilitation Alzheimer's Disease Feasibility (TADF)
This is a pilot RCT with equal arms: experimental arm and (wait list) control arm. All participants will be in the early stage of Alzheimer's disease and on stable medication.
- Trial name
- TADF (NCT04732182)
- Testing
- BrightGo cognitive training, Standard of Care medication for early Alzheimer's Disease
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bright Cloud International Corp
Herpes Zoster
Immunogenicity and Safety of SYS6017 in the Participants Aged 40 Years and Above
Herpes zoster is caused by the reactivation of latent varicella-zoster virus (VZV) which stays in latency after its primary infection. Immunosenescence contributes significantly to elevating morbidity associated with aging.
- Trial name
- NCT07354659
- Testing
- A zoster mRNA vaccine SYS6017, Active Comparator Vaccine
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- CSPC Megalith Biopharmaceutical Co.,Ltd.
Alzheimer Disease
The Sleep Amyloid, Slow WAve Race and Ethnicity Study
African-Americans (AAs) have an increased prevalence of both Alzheimer's disease (AD) and vascular risk factors for AD such as diabetes and hypertension when compared to whites.
- Trial name
- Sleep AWARE (NCT03814603)
- Testing
- PET-MR Scan, PiB
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Atopic Dermatitis Eczema, Aging
Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals
The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in Singapore individuals with eczema.
- Conditions
- Atopic Dermatitis Eczema, Aging, Diet Modification
- Trial name
- NCT06454942
- Testing
- Nutrient-fortified egg, Regular egg with habitual diet
- Where
- Singapore
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Influenza, Human
A Study to Assess the Immunogenicity and Safety of a Trivalent Influenza Vaccine Containing the 2013/2014 Formulation of Enzira® Vaccine in Healthy Volunteers
This is a study to assess the immune (antibody) response and safety of a bioCSL split virion, inactivated influenza vaccine containing the 2013/2014 formulation of Enzira® vaccine in healthy adult volunteers aged between 18 and…
- Trial name
- NCT01863433
- Testing
- Trivalent Influenza Vaccine
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Seqirus
Aging, Hyperthermia
Cardiovascular Responses to Heat Waves in the Elderly
The purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions
- Trial name
- NCT04538144
- Testing
- Hot and Humid Trial, Hot and Dry Trial
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Inflammation, Insulin Sensitivity
Exercise and Inflammation in the Elderly
Persistent low-grade inflammation and impaired fibrinolysis, are independent predictors of several chronic diseases highly prevalent in the older Veteran population including cardiovascular disease (CVD), stroke, and diabetes.
- Trial name
- IRIS (NCT00753363)
- Testing
- Weight Loss, Aerobic Exercise Training
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hepatitis B
Comparing Immunogenicity and Safety of Different Formulations of HBV-MPL Vaccine With Engerix™-B in Adults Aged 18-40 y
This study will evaluate the immunogenicity and safety of different formulations of the candidate HBV-MPL vaccine administered according to a 2-dose schedule and compare it to that of Engerix™-B administered according to a 3-dose…
- Trial name
- NCT00698555
- Testing
- HBV-MPL vaccine, Engerix™-B
- Where
- Belgium
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Delayed Emergence From Anesthesia, Postoperative Delirium
Trajectory of Recovery in the Elderly
The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who will be evaluated with a…
- Conditions
- Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- TORIE (NCT02275026)
- Testing
- Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post-operation Delirium, Alpha-synucleinopathy Related Non-motor Symptom
Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery
Hypothesis is that the presence of a-synucleinopathy related non motor symptoms could be predictive factor for post-operative delirium.
- Trial name
- NCT02550626
- Where
- South Korea
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Influenza, Pandemic Influenza
Phase 1 Study of a H5N1 Influenza Vaccine (Reverse Genetic Reassortant)
The objectives of this study are to assess the dose-related safety and immunogenicity of six different dose levels of inactivated, Vero cell-derived reverse genetic reassortant A/H5N1/Indonesia/05/2005 influenza vaccine in a…
- Trial name
- NCT00783926
- Testing
- H5N1 Influenza Vaccine, Whole virion, Vero cell-derived, Inactivated Influenza Vaccine, non-adjuvanted (reverse genetic reassortant/H5N1 hemagglutinin antigen)
- Where
- 6 sites in United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
COVID-19
Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell)
Popular topic:A Clinical Study of Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell) Overall design:The study was designed as a randomized, open and controlled study.
- Trial name
- NCT05574985
- Testing
- Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell), Inactivated COVID-19 vaccine (Vero Cell)
- Where
- China
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Healthy
Glycemic and Insulinemic Index Determination of Two Products: Fructilight® and A Fruit Fructo-Oligosaccharides in Sweet Matrix
The aim of the study is to determine glycemic and insulinemic index of 2 sweet syrups : FructiLight® and fruit Fructo-oligosaccharides in sweet matrix compared to glucose.
- Trial name
- IGNUT (NCT01343797)
- Testing
- Glycemic and insulinemic index tests of a fruit fructose syrup and a fruit fructo-oligosaccharid syrup
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CRITT Bio-Industries
Low Back Pain, Obesity
WATERinMOTION Aquatic Exercise Program Compared to Land-Based Rehabilitation on Low-Back Pain Relief and Quality of Life
This randomized controlled trial compares the efficacy of an 8-week WATERinMOTION aquatic exercise program versus land-based rehabilitation for reducing low-back pain (LBP) and improving quality of life in sedentary…
- Conditions
- Low Back Pain, Obesity, Sedentary Behavior
- Trial name
- WATERinMOTION (NCT06946342)
- Testing
- "Aquatic Exercise Group", Land-Based Rehabilitation Group"
- Where
- Iran
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Meningitis, Meningococcal
A Phase III Clinical Trial of the Group A and C Meningococcal Polysaccharide Vaccine
This study is a randomized, double-blinded, and controlled phase III clinical trial of the Group A and C meningococcal polysaccharide vaccine to evaluate the safety and immunogenicity of the vaccine in healthy infants aged 2-6…
- Trial name
- NCT04689191
- Testing
- Experimental Group A and C meningococcal polysaccharide vaccine, Control Group A and C meningococcal polysaccharide vaccine
- Where
- China
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
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