Clinical trials: Geriatric Disorders
Overweight
The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.
A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and…
- Trial name
- NCT04248127
- Testing
- Honey sweetened yogurt, Sugar sweetened yogurt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Elderly Patients, Metastatic Colorectal Cancer
QoL in mCRC Elderly Patients Receiving First-line Therapy Based on Simplified Geriatric Parameters.
A national, multicenter, open-label, randomized phase III study. The trial aim is to determine the best therapeutic strategies according with the HRQoL.
- Conditions
- Elderly Patients, Metastatic Colorectal Cancer, Quality of Life
- Trial name
- COLAGE (NCT03828227)
- Testing
- OPTIMOX-bevacizumab, Capecitabine plus bevacizumab
- Where
- 22 sites in France
- Volunteers
- 49 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Healthy Middle-aged Subjects, Obesity & Overweight
Stearic Acid and Endothelial Function
The goal of this clinical trial is to evaluate the postprandial and long-term effects of dietary stearic acid on vascular function in overweight or obese adult males and females aged 40-70 years.
- Trial name
- NCT07831603
- Testing
- High Palmitic Acid Diet, Stearic Acid Test Meal, Oleic Acid Test Meal
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Florida State University
Multiple Myeloma
Integrating Touchscreen-based Geriatric Assessment and Frailty Screening for Adults With Multiple Myeloma
The overarching objective of this study is to evaluate the feasibility, usability, and acceptability of an abbreviated, tablet-based geriatric assessment in a population of older adults with multiple myeloma.
- Trial name
- NCT03068637
- Testing
- Carevive CPS
- Where
- 2 sites in United States
- Volunteers
- 165 people
- Sponsor
- Carevive Systems, Inc.
Blindness
Blind Elderly Melatonin Treatment Study
The primary focus of this five-year study will be to optimize the melatonin dosing regimen for synchronizing the body clocks of elderly blind individuals to the 24-hour day.
- Trial name
- NCT00692094
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Atopic Dermatitis
A Study to Determine the Safety and Tolerability of Dupilumab (REGN668/SAR231893) in Patients Aged ≥6 to <18 Years With Atopic Dermatitis (Eczema)
The primary objective of the study is to characterize the safety and pharmacokinetics (PK) of dupilumab in pediatric patients with moderate-to-severe atopic dermatitis (AD) (for adolescents ≥12 to <18 years of age) or severe AD…
- Trial name
- NCT02407756
- Testing
- Dupilumab
- Where
- 26 sites in Canada, Czechia and 4 more
- Volunteers
- 78 people
- Sponsor
- Regeneron Pharmaceuticals
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Preoperative Sleep Disorder, Preoperative Anxiety
Relationship Between Perioperative Related Factors and Inflammatory Markers and Postoperative Delirium in Elderly Patients With Non-cardiac Major Surgery
Perioperative neurocognitive impairment, including postoperative delirium (POD), is common in older patients after anesthesia and surgery and is associated with poorer short- and long-term outcomes, including worsening cognitive…
- Conditions
- Preoperative Sleep Disorder, Preoperative Anxiety, Inflammatory Reaction, Postoperative Delirium
- Trial name
- NCT05341531
- Testing
- elderly patients undergoing non-cardiac surgery
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Influenza
Study to Evaluate the Safety and Immunogenicity of GSK Biological Pandemic Candidate Influenza Vaccine (H1N1) in Children
The objective of this study is to evaluate the safety and immunogenicity study of GSK Biologicals' pandemic influenza candidate vaccine (GSK2340272A) in children aged 3 to 9 years.
- Trial name
- NCT01014091
- Testing
- GSK pandemic vaccine GSK2340272A
- Where
- 3 sites in Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depression, Dementia
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in…
- Conditions
- Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression
- Trial name
- ONR (NCT05531591)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 4 sites in United States, Canada
- Volunteers
- 87 people
- Sponsor
- Centre for Addiction and Mental Health
Dynamic Balance, Risk of Fall
Effects of Combined Cervical and Oculomotor Exercises on Dynamic Balance in Elderly
This study focuses on improving balance in elderly individuals (aged 60-80 years) who may experience dizziness or instability while walking or performing daily activities.
- Trial name
- NCT07608991
- Testing
- occulomotor with otago exercises, Combined Cervical and Oculomotor Exercises with Otago Exercises
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Mild Cognitive Impairment
Efficiency of CogniPlat on Cognitive Functions in Older Adults
Mild cognitive impairment is a common intermediate stage between normal aging and dementia, affecting memory and other cognitive domains in older adults.
- Trial name
- NCT07130591
- Testing
- Cogniplat game platform, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Acute Myeloid Leukemia
Safety and Efficacy Study of Pracinostat With Azacitadine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
The purpose of this study is to determine the safety and effectiveness of pracinostat when combined with azacitadine for patients who are 65 years of age or older and have Acute Myelogenous Leukemia (AML)
- Trial name
- NCT01912274
- Testing
- Pracinostat, Azacitidine
- Where
- 17 sites in United States
- Volunteers
- 50 people
- Sponsor
- Helsinn Healthcare SA
Lung Cancer
Two Regimens of Docetaxel in Treating Patients Who Have Not Received Chemotherapy For Unresectable Stage IIIB or Stage IV Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00075374
- Testing
- docetaxel
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer Stage I, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
CRYO-1: Cryoablation in Elderly Patients With Early-Stage Breast Cancer.
This study looks at a new way to treat early-stage breast cancer in older adults using a freezing technique called cryoablation.
- Trial name
- CRYO-1 (NCT07398118)
- Testing
- Cryoablation / Cryotherapy
- Where
- 3 sites in Netherlands
- Volunteers
- 61 people
- Sponsor
- St. Antonius Hospital
Anxiety Disorders, Depression
Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging
The investigators are developing and then testing whether Mindfulness-Based Stress Reduction, a group-based instruction for increasing mindfulness, reduces anxiety and depressive symptoms and improves cognitive functioning in…
- Trial name
- NCT01693874
- Testing
- MBSR, control (health education)
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Washington University School of Medicine
Tooth Wear, Attrition
Prevalence of Tooth Wear and Its Association with Oral Health-related Quality of Life
The aim of this study is to detect the prevalence of tooth wear (All forms of cumulative surface loss of mineralized tooth substance loss due to physical and chemico-mechanical process according to the definition of the European…
- Conditions
- Tooth Wear, Attrition, Erosion
- Trial name
- NCT06665191
- Testing
- No Intervention: Observational study for prevalence of dental wear and its association with quality of life
- Volunteers
- 1,011 people, healthy volunteers welcome
- Sponsor
- Cairo University
Colorectal Neoplasms, Aged
Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery
To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of…
- Trial name
- NCT04516174
- Testing
- Transversus abdominis plane block using ropivacaine, Dexmedetomidine, Transversus abdominis plane block using saline
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Tiantan Hospital
MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
AGED Diagnostics Clinical Validation Study
Validation of Blood-Based Tests for the Diagnosis of Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Liver Fibrosis: This study aims to validate two investigational blood tests developed by AGED Diagnostics for the…
- Conditions
- MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease), Fibrosis and Cirrhosis of Liver, MetALD
- Trial name
- NCT07867574
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Active Genomes Expressed Diagnostics, Corp
Menorrhagia
Menorrhagia Study in Women With Treatment-resistant Menorrhagia
The aim of this study is to explore effects of the investigational product for the treatment of treatment-resistant menorrhagia without organic cause.
- Trial name
- NCT00288691
- Testing
- Asoprisnil (BAY86-5294)
- Volunteers
- 26 people
- Sponsor
- Bayer
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