Clinical trials: Geriatric Patients
COPD,Pulmonary Disease, Chronic Obstructive ,Pulmonary Disease, Chronic Obstructive
Effect of Introducing Digital Multimedia Nursing on Improving With COPD
COPD is a progressive and irreversible lung disease characterized by persistent airflow limitation, dyspnea, chronic cough, and impaired daily functioning, often accompanied by comorbidities that reduce quality of life.
- Trial name
- COPD (NCT07419906)
- Testing
- E-book on Pulmonary Obstruction
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Fu Jen Catholic University Hospital
Advanced or Metastatic NSCLC
A Study to Investigate Efficacy and Safety of Ceralasertib Plus Durvalumab in Participants Aged ≥ 18 Years With Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Progressed on or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy
A study to investigate efficacy and safety of ceralasertib plus durvalumab in participants aged ≥ 18 years with advanced or metastatic non-small cell lung cancer whose disease progressed on or after prior anti-PD-(L)1 therapy and…
- Trial name
- LOTOS (NCT05941897)
- Testing
- Ceralasertib, Durvalumab
- Where
- 8 sites in Russia
- Volunteers
- 39 people
- Sponsor
- AstraZeneca
Knee Osteoarthritis, Sensation Disorders
The Effect of Cycle Ergometer With Biofeedback on Deep Sensation in Elderly Patients With Knee Osteoarthritis
The aim of the randomized controlled study is to investigate the effects of the cycle ergometer with biofeedback on deep sensation in elderly people who has knee osteoarthritis
- Trial name
- NCT05836792
- Testing
- Cycle Ergometer, Transcutaneous electrical nerve stimulation, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Nilay Aral
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Cardiovascular Disease, Chronic Kidney Disease
Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
The goal of this proposal is to investigate the potential for ACE-inhibitors (ACE-I)(drugs primarily used to treat hypertension or congestive heart failure) to prevent or delay cardiovascular disease (CVD) in older adults with…
- Trial name
- NCT00874432
- Testing
- angiotensin converting enzyme inhibitor, lisinopril
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Femoral Neck Fracture
Allogeneic Mesenchymal Stromal Cells in Elderly Patients With Hip Fracture
Prospective, unicenter, randomized, open-label, single-dose, two-arms blinded assessor pilot study. Thirty-two (32) elderly patients with hip fracture will be randomized to one of the two treatment-arms (Xcel-MT-osteo-beta or…
- Trial name
- NCT02630836
- Testing
- XCEL-MT-OSTEO-BETA, Surgical treatment
- Sponsor
- Banc de Sang i Teixits
Displaced Fracture Neck Femur, Total Hip Arthroplasty (THA)
Total Hip Arthroplasty Versus Bipolar Hemiarthroplasty for Treatment of Intracapsular Displaced Fracture Neck Femur in Elderly Active Patients
Femoral neck fracture (FNF) is a worldwide health problem that can cause significant morbidity and mortality. Most femoral neck fractures are associated with a fall, and the risk factors include osteoporosis, chronic medication…
- Conditions
- Displaced Fracture Neck Femur, Total Hip Arthroplasty (THA), Bipolar Hemiarthroplasty, Elderly Active Patients
- Trial name
- NCT07409909
- Testing
- Total Hip Arthroplasty, Bipolar Hemiarthroplasty
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Malnutrition
Evaluation of Effectiveness of Nutritional Practical Counseling for Elderly Patients at Risk of Malnutrition on Nutritional Status at Home
At hospital, short term actions are used (adaptation of meals, oral supplementation…) to fight malnutrition. Oral supplementation can have a positive impact on weight gain.
- Trial name
- NutriPratiC (NCT02796521)
- Testing
- dietary counseling, nutritional workshop with enrichment during a meal
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Post Induction Hypotension, Elderly
Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients
Geriatric patients undergoing general anesthesia face a significant challenge, with the induction phase contributing to 50% of hypotensive events.
- Trial name
- CTIH (NCT06258967)
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Deprescriptions, Antidepressive Agents
Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy
The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER…
- Conditions
- Deprescriptions, Antidepressive Agents, Antipsychotic Agents, Analgesics, Opioid
- Trial name
- PARTNER (NCT05842928)
- Testing
- PARTNER intervention, Control intervention
- Where
- 3 sites in Germany
- Volunteers
- 352 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Heart Failure, Comorbidity
Efficacy of a Disease Management Program in Very Old Patients With Heart Failure
The purpose of this study is to assess the efficacy of a disease management programme (DMP) for very old patients with HF and significant co-morbidity.
- Conditions
- Heart Failure, Comorbidity, Case-manager
- Trial name
- NCT01076465
- Testing
- Disease management program, Usual care
- Where
- Spain
- Volunteers
- 700 people
- Sponsor
- Hospital de Meixoeiro
Cardiac Surgery, Elderly Patient
Preoperative Nutritional Status Scores to Predict PPC in Elderly With Cardiac Surgery
This prospective study investigates prognostic values and compares the role of nutritional status by using GNRI, MNA-SF, PNI, and NAF in predicting post-operative pulmonary complication among elderly patients with cardiac surgery.
- Conditions
- Cardiac Surgery, Elderly Patient, Postoperative Pulmonary Complication, Nutrition Scoring System
- Trial name
- NCT06340464
- Testing
- Nutrition scoring systems
- Where
- Thailand
- Volunteers
- 217 people
- Sponsor
- Prince of Songkla University
Non-Small Cell Lung Cancer
Phase II Study Alimta and Gemzar + Avastin as First Line Chemotherapy for Elderly Patients With Stage IIIB/IV NSCLC
The primary objective is to determine the progression free survival with pemetrexed, and gemcitabine plus bevacizumab as first-line chemotherapy in elderly patients with Stage IIIB/IV non-small cell lung cancer (NSCLC).
- Trial name
- NCT00517595
- Testing
- Pemetrexed and Gemcitabine plus Bevacizumab
- Where
- 10 sites in United States
- Volunteers
- 48 people
- Sponsor
- Accelerated Community Oncology Research Network
Diffuse Large B Cell Lymphoma
Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma
To explore the clinical features and efficacy evaluation of large b-cell lymphoma in old age.
- Trial name
- NCT03513601
- Testing
- (R)-CHOP regimen, (R)-CVP regimen
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Mingzhi Zhang
Chronic Heart Failure, Obstructive Sleep Apnea
CPAP and Physiotherapy for Heart Failure and Sleep Apnea in the Elderly
This study evaluates whether adding physiotherapy (including herbal medicine, acupuncture, and Tuina massage) to standard continuous positive airway pressure (CPAP) therapy can provide superior benefits compared to CPAP alone for…
- Trial name
- NCT07061171
- Testing
- Continuous Positive Airway Pressure, Herbal Decoction, Acupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Weihua Peng
Cognitive Deterioration
Pain Management in Elderly Patients With or Without Cognitive Frailty Hospitalized "ALGOGER"
Today, the standard treatment is to operate on patients suffering from a fracture of the upper end of the femur. The aim of treatment is to enable immediate mobilization and weight-bearing, and as rapid a return as possible to…
- Trial name
- ALGOGER (NCT06056934)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coronary Artery Disease
Comparison of Prasugrel and Clopidogrel in Very Elderly and Non-Elderly Patients With Stable Coronary Artery Disease
The 5-milligram (mg) maintenance dose (MD) of prasugrel in very elderly patients with coronary artery disease produces a pharmacodynamic response within the same therapeutic range as 10-mg MD in non-elderly patients.
- Trial name
- GENERATIONS (NCT01107912)
- Testing
- prasugrel, clopidogrel
- Where
- 7 sites in United States, Ireland and 2 more
- Volunteers
- 155 people
- Sponsor
- Eli Lilly and Company
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
PONV, BIS
Effect of BIS-Guided Anesthesia on Postoperative Nausea and Vomiting in Pediatric Patients
This randomized controlled trial will evaluate the effect of bispectral index (BIS)-guided anesthesia on postoperative nausea and vomiting (PONV) in children aged 3-8 years undergoing elective adenoidectomy.
- Trial name
- NCT07189845
- Testing
- BIS GROUP, CONTROL GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Engin Çetin
Leukemia, Neutropenia
Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Colony-stimulating factors such as G-CSF may increase the number of immune cells found in the bone marrow or…
- Trial name
- NCT00002719
- Testing
- filgrastim, amsacrine, carmustine
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC