Clinical trials: Gestational Trophoblastic Neoplasia
Anxiety Disorder, Cervical Cancer
Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic Cancer
This randomized pilot clinical trial studies the feasibility of a pre-operative and/or post-operative scripted sexual health informational intervention and how well it works in improving sexual function in patients with…
- Conditions
- Anxiety Disorder, Cervical Cancer, Endometrial Cancer, Female Reproductive Cancer
- Trial name
- NCT02096783
- Testing
- informational intervention, counseling intervention, questionnaire administration
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Hydatidiform Mole
A Multi-center Cohort Study of Hydatidiform Mole in China (CN-HM-01)
This observational study aims to establish a national cohort of patients with hydatidiform mole (molar pregnancy) to investigate its malignant transformation rate and malignant transformation mechanisms, with the goal of…
- Trial name
- CN-HM-01 (NCT07202728)
- Testing
- No intervention
- Where
- 14 sites in China
- Volunteers
- 1,489 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Hydatidiform Mole
RCT on the Efficacy of Methotrexate for the Prevention of GTD
A randomized, controlled trial to evaluate the efficacy of methotrexate for the prevention of postmolar gestational trophoblastic disease among patients with high-risk hydatidiform mole.
- Trial name
- NCT01984099
- Testing
- Methotrexate, Vitamin B Complex
- Where
- Philippines
- Volunteers
- 99 people
- Sponsor
- University of the Philippines
Cancer
Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant
RATIONALE: Methotrexate and glucocorticoid therapy, such as prednisone or methylprednisolone, may be an effective treatment for acute graft-versus-host disease caused by a donor stem cell transplant.
- Trial name
- NCT00357084
- Testing
- methotrexate, methylprednisolone, prednisone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Gestational Trophoblastic Neoplasia
Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6
Whether toripalimab plus actinomycin-D as fist-line treatment can achieve a higher complete response rate than actinomycin-D alone.
- Trial name
- TA56 (NCT06028672)
- Testing
- Toripalimab, Actinomycin-D
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Hydatidiform Moles
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles
The researchers' laboratory is studying a rare class of highly recurrent hydatidiform moles. These are usually complete hydatidiform moles (CHM), but sometimes they are partial hydatidiform moles PHM).
- Trial name
- NCT01008501
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Gestational Trophoblastic Tumor
Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of dactinomycin in treating patients who have persistent…
- Trial name
- NCT00003688
- Testing
- dactinomycin
- Where
- 29 sites in United States, Norway
- Sponsor
- Gynecologic Oncology Group
Choriocarcinoma, FIGO Stage I Gestational Trophoblastic Tumor
Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
This randomized phase III trial studies how well methotrexate works compared to dactinomycin in treating patients with low-risk gestational trophoblastic neoplasia.
- Conditions
- Choriocarcinoma, FIGO Stage I Gestational Trophoblastic Tumor, FIGO Stage II Gestational Trophoblastic Tumor, FIGO Stage III Gestational Trophoblastic Tumor
- Trial name
- NCT01535053
- Testing
- Dactinomycin, Leucovorin Calcium, Methotrexate
- Where
- 289 sites in United States, Canada and 3 more
- Volunteers
- 57 people
- Sponsor
- GOG Foundation
Gestational Trophoblastic Tumor, Effects of Chemotherapy
Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma （GTN） Patients With Score of 5-6
In this study, a prospective, multicenter randomized controlled study was conducted to compare the clinical efficacy and toxicity response of combination MTX+ACTD multi-course regimen in low-risk GTN patients with score 5-6 with…
- Conditions
- Gestational Trophoblastic Tumor, Effects of Chemotherapy, Drug Toxicity
- Trial name
- NCT03885388
- Testing
- MTX, MTX+ACTD
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Gestational Trophoblastic Neoplasia
The Psychological Impact of GTN on Women Who Have Completed Chemotherapy Treatment
A cross-sectional retrospective study of a sample of 20 women who completed single agent or multi agent chemotherapy: between 6 weeks and 24 months post treatment involving a semi structured telephone interview.
- Trial name
- PI-GTN (NCT06169644)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cancer
Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant
RATIONALE: Giving donor natural killer cells to patients who have undergone donor bone marrow transplant may make the transplant work better and keep cancer cells from coming back.
- Trial name
- NCT00569283
- Testing
- therapeutic allogeneic lymphocytes
- Where
- 2 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Asan Medical Center
Cancer
Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation
RATIONALE: Acupuncture may be effective in relieving mucositis-related pain caused by chemotherapy in patients undergoing stem cell transplantation.
- Trial name
- NCT00060021
- Testing
- acupuncture therapy, management of therapy complications, pain therapy
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Gestational Trophoblastic Disease
Letrozole as a Prophylaxis From GTN for Complete Mole Patients
Prophylactic use of aromatase inhibitor is effective in decreasing the incidence of Gestational Trophoblastic Neoplasia (GTN) in patients with complete hydatidiform mole (CHM)
- Trial name
- NCT05203562
- Testing
- Suction evacuation, Letrozole tablets
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Zagazig University
Breast Cancer, Chronic Myeloproliferative Disorders
Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00900406
- Testing
- gene expression analysis, microarray analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Cancer
Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients
RATIONALE: Liposomal amphotericin B may be effective in controlling fever and granulocytopenia. It is not yet known which regimen of liposomal amphotericin B is more effective in treating cancer patients who have these…
- Trial name
- NCT00003938
- Testing
- liposomal amphotericin B
- Where
- 24 sites in Belgium, Czechia and 13 more
- Volunteers
- 115 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant
This pilot clinical trial studies mechanical stimulation in preventing bone density loss in patients undergoing donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01558778
- Testing
- management of therapy complications, musculoskeletal complications management/prevention
- Sponsor
- Roswell Park Cancer Institute
Neoplasm, Trophoblastic, Gestational Trophoblastic Disease
The French National Reference Centre of GTD
The French Gestational Trophoblastic Disease (GTD) centre has been set up and active by registering, monitoring and treating women with GTD since november 1999.
- Conditions
- Neoplasm, Trophoblastic, Gestational Trophoblastic Disease, Hydatidiform Mole, Hydatidiform Mole, Invasive
- Trial name
- French GTDC (NCT02892877)
- Where
- France
- Volunteers
- 25,500 people
- Sponsor
- Hospices Civils de Lyon
Cancer
Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
RATIONALE: Heparin or M-EDTA may prevent catheter-related infections and blockages in patients at high risk for a catheter-related infection.
- Trial name
- NCT00378781
- Testing
- Heparin, Minocycline-EDTA
- Sponsor
- M.D. Anderson Cancer Center
Uterine Cancer, Cervix Uteri Nos
A Global Assessment of Medical, Emotional and Reproductive Concerns in Gestational Trophoblastic Disease Survivors
The purpose of this study is to collect information on the effects of treatment for gestational trophoblastic disease (GTD). We plan to use the findings from this study to better understand GTD survivors' health and quality of…
- Conditions
- Uterine Cancer, Cervix Uteri Nos, Gestational Trophoblastic Disease
- Trial name
- NCT00706875
- Testing
- questionnaire
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as thrombopoietin and G-CSF may increase the number of immune cells found in…
- Trial name
- NCT00003597
- Testing
- recombinant human thrombopoietin, carboplatin, etoposide
- Where
- 24 sites in United States, Australia
- Volunteers
- 16 people
- Sponsor
- Children's Oncology Group