Clinical trials: Gingival Condition
Periodontitis
Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37
The aims of our study were 1) to evaluate levels of gingival crevicular fluid( GCF) human cathelicidin peptide LL-37 and serum vitamin D3 in smoker and non-smoker patients with chronic periodontitis(CP) 2) to determine whether…
- Trial name
- NCT03923218
- Testing
- LL-37 levels in Gingival crevicular fluid, Serum Vitamin D3 levels, Clinical parameters
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Dental Plaque, Gingivitis
Essential Oil+ELA, Plaque and Gingivitis
A commercially available mouth rinse with ethyl lauroyl arginate and essential oils claims to have enhanced antimicrobial properties as compared to the traditional essential oil products.
- Trial name
- NCT02884817
- Testing
- Experimental: essential oils and ELA, Water
- Where
- Norway
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Gingival Recession
Tunnel vs. CAF for the Treatment of Multiple Gingival Recessions
Many studies have compared the tunnel technique and coronally advanced flap in the treatment of single and multiple recessions. However, there is a lack of evidence that compared both techniques in combination with a connective…
- Trial name
- NCT05122468
- Testing
- Connective tissue Harvest and CAF, Connective tissue Harvest and Tunnel
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Gingival Recession
Evaluation of Esthetic Root Coverage Using Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft With Vestibular Incision Subperiosteal Tunnel Access in Multiple Gingival Recessions
Patients with gingival recession, complain of excessive tooth length that affects their appearance during smiling or functioning.
- Trial name
- NCT03588052
- Testing
- VISTA using PRF, VISTA using SCTG
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Overgrowth, Gingival Hyperplasia
Effect of Injectable Platelet-rich Fibrin (i-PRF) on Wound Healing After Gingivectomy
This study evaluates the clinical and biochemical effects of injectable platelet-rich fibrin (i-PRF) on wound healing after gingivectomy, a surgical procedure used to treat gingival overgrowth.
- Trial name
- i-PRF-GIN (NCT07785349)
- Testing
- injectable Platelet-Rich Fibrin (i-PRF), Conventional Gingivectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Şeyma Çardakçı
Gingivitis, Periodontal Diseases
Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Systems
Although the well-known detrimental effects of conventional cigarette smoking on oral health, there are still lack of evidences about the impact of less harmful alternatives (such as electronic cigarettes or heat not burn…
- Trial name
- SMILE (NCT04649645)
- Testing
- TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS), NOT SMOKING
- Where
- Italy
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Eclat Srl.
Root Resorption, Plaque Accumulation
Comparison of Canine Retraction Using Ni-ti Closed-coil Springs Vs Elastomeric Power Chains During Orthodontic Treatment
The objective of this study is to compare the canine retraction rate (in mm with a 100 mm marked scale) using Ni-Ti closed-coil springs versus elastomeric power chains during canine retraction in subjects with first premolar…
- Conditions
- Root Resorption, Plaque Accumulation, Gingivitis
- Trial name
- NCT06567730
- Testing
- Ni-ti Closed-coil Spring, Elastomeric Power chain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Munnal Gulzar
Gingival Recession, Localized
Bi-layer Collagen Membrane Versus Subepithelial Connective Tissue Graft in the Treatment of Localized Gingival Recession
The goal of this clinical trial is evaluation of the change in depth and width of gingival recession in terms of gingival thickness and esthetics, and evaluation of patient satisfaction in terms of postoperative pain and final…
- Trial name
- NCT07162207
- Testing
- Pinhole surgical technique
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis
Er:YAG Laser and Air Polishing Application in Periodontal Treatment
Periodontitis (gum disease) is an infection of the gums that can lead to tooth loss. In recent years, many types of dental lasers or other devices have been used for the non-surgical treatment of periodontal diseases.
- Trial name
- NCT06574802
- Testing
- ERL + air polishing, ERL
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Gingivitis
Effects of Antioxidant Dentifrice on Gingivitis
The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.
- Trial name
- NCT02102295
- Testing
- Experimental toothpaste, Control toothpaste
- Where
- 4 sites in Japan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Lion Corporation
Gingival Recession, Localized
Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline
The goal of this study is to assess the reconstruction of interdental papilla following the injection of UC-MSCs or physiological saline in patients with interdental papilla deficiency.
- Trial name
- NCT06388447
- Testing
- Umbilical cord-mesenchymal stem cells
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Gingival Recession
Ubiquinone (Coenzyme Q10) Application After Gingival Recession Coverage
This randomised double blinded clinical trial has the aim to assess the effect of ubiquinone (Coenzyme Q10) on early wound healing following gingival recession coverage.
- Trial name
- NCT04487652
- Testing
- Gingival recession coverage, with CoQ10 spray application
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bern
Obesity, Periodontitis
The Role of Visfatin in Obesity and Periodontal Disease
Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and proinflammatory mediator.
- Trial name
- NCT03470987
- Testing
- Phase I Periodontal therapy, Metabolic control
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontitis, Periodontal Diseases
Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response.
- Conditions
- Periodontitis, Periodontal Diseases, Smoking, Smoking, Tobacco
- Trial name
- NCT05281848
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gazi University
Obesity, Overweight
Chewing Gum for Weight Loss
This is a randomized controlled trial of the effects of chewing gum on body weight. The investigators will randomly assign 200 overweight or mildly obese adults to one of two groups.
- Conditions
- Obesity, Overweight, Weight Loss
- Trial name
- NCT00971347
- Testing
- Extra sugar-free chewing gum sticks, nutrition brochure
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Open Wound of Palate Without Complication, Pain, Postoperative
The Effect of Ozone Therapy on Pain Perception After Free Gingival Graft Surgery in Patients With Mucogingival Defects
Gaseous ozone (O3-triatomic oxygen) is the third-strongest oxidizing agent worldwide. It influences the cellular and the humoral immune system, by stimulating the proliferation of immunocompetent cells and the synthesis of…
- Conditions
- Open Wound of Palate Without Complication, Pain, Postoperative, Free Gingival Grafts, Mucogingival Defects
- Trial name
- NCT05291715
- Testing
- Ozone generator device (Ozone DTA-APOZAa-enterprize CO9-Taiwan, R.0.C)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Omaima Mossad Mahmoud AL-Sherbini
Peri-Implantitis, Peri-implant Mucositis
Lingual Keratinized Tissue in Fully Edentulous Patients and Its Impact on Implant Health
Cross-sectional study involving the measurement of the width of lingual keratinized tissue (in the implant locations) in fully edentulous patients restored with dental implants.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Recession, Gingival
- Trial name
- NCT06166017
- Testing
- Exposure to minimal amount of lingual keratinized tissue width
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- George Eastman Dental Hospital, Italy
Periodontal Diseases
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective
The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity.
- Trial name
- NCT06261723
- Testing
- non-chirurgical periodontal treatment
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Dental Caries, Probiotics
Effect of Probiotics on Oral Homeostasis During Sugar Stress
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
- Conditions
- Dental Caries, Probiotics, Gingivitis
- Trial name
- NCT05073393
- Testing
- Sugar stress
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gingival Recession
Two Techniques for Root Coverage With a Xenogeneic Collagen Matrix
Gingival recessions are often successfully treated by coronally advanced flap technique (CAF) associated with subepithelial connective tissue grafts (SCTG).
- Trial name
- NCT02129504
- Testing
- root coverage comparing two techniques
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
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