Clinical trials: Gingival Condition
Periodontitis, Adult
GCF miRNA-223 , -214 Levels in Smokers and Nonsmokers Periodontitis Patients
Objective: Periodontitis is a multifactorial disease that affects a wide range of populations. However, its pathogenesis remains unclear. miRNAs are now considered potential diagnostic markers for many inflammatory diseases.
- Trial name
- NCT06064799
- Testing
- miRNA-223 & -214 detection
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Gingivitis, Plaque
COMORAL® the Oral Irrigation Unit Clinical Trial
This is a clinical study to evaluate the safety and effectiveness of COMORAL®, the intraoral water-spraying cleaning device that is developed to remove plaque around teeth in the oral cavity.
- Trial name
- COMORAL (NCT05031260)
- Testing
- applying COMORAL®
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gingivitis; Chronic
Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis
This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and…
- Trial name
- NCT07689786
- Testing
- Miswak, Toothpaste
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Oral Lichen Planus
Impact of Topical Clobetasol on Gingival Crevicular Fluid miRNAs in Subjects Affected by Oral Lichen Planus
According to recent research, microRNAs (miRNAs) may function as early disease indicators and contribute to the severity of a number of precancerous and malignant oral disorders.
- Trial name
- NCT05818618
- Testing
- Clobetasol Topical Gel
- Where
- Italy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Catania
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gingivitis, DMFT Index
Motivational Interviewing to Improve Oral Hygiene in Adolescent Orthodontic Patients
This study is being conducted to explore how motivational interviewing (MI), A patient-centered counseling method, can help improve oral health awareness and practices in adolescents undergoing orthodontic treatment.
- Conditions
- Gingivitis, DMFT Index, Dental Plaque Index, Oral Hygiene Education Methods
- Trial name
- MI-Ortho (NCT07164989)
- Testing
- Motivational Interviewing-Based Counseling, Standard Oral Health Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gingivitis
The Effect of Probiotics on Gums Health and Bad Breath
the study is about using healthy bacteria to improve the overall gingival and overall health and prevent or decrease the bad odor of the mouth caused by bad bacteria
- Trial name
- NCT06910397
- Testing
- Probiotic Arm
- Where
- Iraq
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Dental Caries, Gingivitis
Effect of a 2-week Sugar Stress on Bacterial Profiles in Whole Saliva
Dental caries is a non-communicable biofilm-mediated disease affecting both crown and exposed root surfaces in the primary and permanent dentitions.
- Trial name
- NCT04199897
- Testing
- Succrose rinsing, Probiotic lozenges, xylitol rinsing
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontitis
IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls
Periodontitis is an inflammatory disease characterized by periodontal tissue destruction caused by bacterial infection. The immune response plays an important role in the progression of periodontitis.
- Trial name
- NCT05306860
- Testing
- No intervention was applied to the groups the samples will be collected in terms of the diagnosis (periodontitis, healthy)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Gingival Recession
Periodontal Phenotype and Laterally Positioned Flap in Isolated Gingival Recession
The aim of this study is to estimate the effect of periodontal phenotype on the outcome of isolated gingival recession by laterally positioned flap.The primary objective of study is to assess the changes in gingival margin in the…
- Trial name
- NCT04255888
- Testing
- Laterally positioned flap in thick periodontal phenotype., Laterally positioned flap in thin periodontal phenotype.
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Cardiovascular Diseases, Periodontal Diseases
Impact of Periodontal Treatment on Local miRNA Expression
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA…
- Trial name
- NCT05275127
- Testing
- changes of gingival crevicular fluid miRNA
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Catania
Periodontitis (Stage 3), Gremlin-1
Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy
eriodontitis is a complex disease characterized by the inflammation and destruction of the tissues supporting the teeth, and smoking can adversely affect the pathophysiological changes in this process.
- Conditions
- Periodontitis (Stage 3), Gremlin-1, Syndecan 4, Interleukin 1-beta
- Trial name
- NCT06687005
- Testing
- non-surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tugba Aydin
Pain, Postoperative, Wound Heal
Clinical Efficacy of Soft Tissue Trimmer in Cases of Gingival Hyperplasia.
Postoperative pain and wound healing are compared after using conventional scalpel technique in comparison with the intervention which is using Soft tissue Trimmer for cases of gingival hyperplasia.
- Conditions
- Pain, Postoperative, Wound Heal, Gingival Hyperplasia
- Trial name
- NCT04542486
- Testing
- Excision of gingival hyperplasia using "Soft tissue trimmer "., Excision of gingival hyperplasia using the conventional scalpel technique
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Peri Implantitis
Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants.
Research Question: Can a minimally invasive, non-surgical treatment approach (MINST) be more effective than the current standard non-surgical method in treating peri-implantitis, a common inflammatory condition affecting dental…
- Trial name
- NCT07365722
- Testing
- Non-Surgical Periodontal treatment (NSPT), Minimally-invasive non-surgical therapy of peri-implantitis
- Volunteers
- 80 people
- Sponsor
- King's College London
Gingival Recession
Treatment of Gingival Recession Using Gingival Composite Restoration Versus Coronally Advanced Flap
Treatment of gingival recession requires favourable anatomical conditions and the use of invasive surgical approaches. Hence, these procedures are not always indicated in all cases and can cause great pain and morbidity.
- Trial name
- NCT04584931
- Testing
- coronally advanced flap, restorative intervention
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mouth, Edentulous
Study to Evaluate Bone and Gum Dimension Changes Around Dental Implants Placed in Different Positions in Bone.
The purpose of this study is to test two standard of care techniques of placing dental implants, and to compare how people's bones and gums respond to two different depths at which implants are placed.
- Trial name
- NCT01759537
- Testing
- Ankylos dental endosseous implants-Sub-crestal, Ankylos dental endosseous implants-Epi-crestal
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dentsply International
Tobacco Dependence
Bupropion Alone or Combined With Nicotine Gum
Focus of this study was to determine if bupropion was more effective for smoking cessation when used alone or combined with nicotine gum.
- Trial name
- NCT01621022
- Testing
- bupropion + nicotine gum
- Where
- United States
- Volunteers
- 608 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cardiac Arrest, Inflammation
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after…
- Conditions
- Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)
- Trial name
- PCAS (NCT02664831)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Gingival Recession
Coronally Advanced Flap With Connective Tissue Graft and PRF for Recession Coverage
Over the years, numerous surgical techniques such as free autografts and pedicle grafts have been introduced to correct gingival recession defects.
- Trial name
- NCT03023995
- Testing
- CAF with Platelet rich fibrin, CAF with connective tissue graft
- Volunteers
- 10 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Gingivitis
Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
- Trial name
- NCT05268757
- Testing
- Oral hygiene discontinuation
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
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