Clinical trials: Gingival Crevicular Fluid
Tooth Abrasion, Gingival Recessions
The Effect of Retraction Cord on the Surrounding Periodontal Tissues in Restorative Treatment
The goal of this clinical trial is to learn whether a retraction cord affects gum health when used during tooth restoration procedures.
- Conditions
- Tooth Abrasion, Gingival Recessions, Non-Carious Cervical Lesions (NCCLs), Periodontal Health
- Trial name
- NCT07734935
- Testing
- Gingival Retraction Cord, Composite Resin Restorative, Universal Adhesive - G-Premio Bond
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Istanbul University
Periodontal Diseases, LDL Hyperlipoproteinemia
Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III/IV Periodontitis
Periodontitis is a chronic, multifactorial inflammatory disease primarily caused by dysbiotic plaque biofilms, characterized by the progressive destruction of the supporting structures of the teeth.
- Trial name
- LDL in GCF (NCT07157878)
- Volunteers
- 40 people
- Sponsor
- shaimaa hamdy
Periodontal Health, Periodontitis
Gingival Crevicular Fluid, Salivary, and Serum Biomarkers Levels in Periodontal Treatment
The present study aimed to assess the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF), saliva, and serum IL-26, IL-6, and IL-10 levels in stage III grade B periodontitis (SIII-GB-P) and C…
- Trial name
- NCT05395455
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Marmara University
Smoking Reduction
Cathelicidin LL-37 Levels in the GCF and the Saliva of Smokers and Non-smokers With Stage III,IV Periodontitis
Periodontitis is considered an inflammatory disease that results in the disruption of oral hemeostasis and is associated with the presence of dental plaque influenced by genetic and environmental factors.
- Trial name
- NCT04861493
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Periodontal Pocket
The Efficacy of Salvia Officinalis Gel in the Treatment of Periodontitis CLINICAL TRIAL
From each participant, two sites of periodontal pockets ( ≥ 5 mm ) were selected and randomly allocated to either the test site (treated with scaling and RSD with S.
- Trial name
- clinical (NCT06900517)
- Testing
- Salvia officinalis Gel
- Volunteers
- 23 people
- Sponsor
- University of Baghdad
Periodontal Diseases
Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
- Trial name
- NCT05281796
- Testing
- GCF obtaining, saliva obtaining
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Generalized Periodontal Disease, AVDC Stage 3
IL-39 & IL-35 Gingival Crevicular Fluid Levels in Diabetic Patients With Generalized Periodontitis
The sudy was aiming to assess and compare GCF levels of IL-39 \& IL-35 in gingival crevicular fluid and to correlate the relationship between different patient groups before and after non-surgical therapy.
- Trial name
- NCT05880654
- Testing
- Scaling & root planning
- Where
- 2 sites in Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Chronic Periodontitis
Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis
Effect of Locally Delivered Antioxidants as An Adjunct to Non-surgical Periodontal Therapy on GCF Level of Oxidative Stress Marker; Protein Carbonyl
- Trial name
- NCT03203746
- Testing
- Lycopene + SRP, SRP only
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maie Sami tawfik
Periodontal Disease (Diagnosis), Diabetes Mellitus, Type 2
Possible Role of Gingival Crevicular Fluid Levels of Chemerin and Fibroblast Growth Factor 21 as Biomarkers of Periodontal Disease in Diabetic and Non-diabetic Patients
The current study aims to spot the light on the possible role of gingival crevicular fluid (GCF) level of Chemerin and FGF21 to study their potential role as biomarkers of periodontal disease and to understand their role in the…
- Trial name
- NCT04012983
- Testing
- gingival crevicular fluid level
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Inflammation, Alveolar Bone Loss
The Effect of Non-surgical Periodontal Treatment on Dickkoff-1 and Secreted Frizzled Related Protein-5 Levels
Periodontitis is a condition that is defined by microbial-associated, host-induced inflammation, which ultimately results in the loss of periodontal attachment.Periodontal clinical parameters are the most reliable indicators of…
- Conditions
- Periodontal Inflammation, Alveolar Bone Loss, Periodontal Diseases
- Trial name
- NCT06727929
- Testing
- Collection of gingival crevicular fluid, ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Gingivitis
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
- Trial name
- NCT06507280
- Testing
- Periodontal theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontal Health, Gingivitis
Salivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis
This observational cross-sectional study aims to compare the levels of irisin, interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) in saliva and gingival crevicular fluid (GCF) among individuals…
- Conditions
- Periodontal Health, Gingivitis, Periodontitis
- Trial name
- NCT07881406
- Testing
- Clinical periodontal examination, ELISA-based biomarker analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Periodontitis
Biomarkers for Periodontitis Relapse
In this clinical study, we have collected GCF at diseased teeth and at the same time drawn blood, both before and at 3, 6 and 12 months after periodontal surgical treatment.
- Trial name
- NCT04663165
- Testing
- Periodontal surgery, Regenerative periodontal surgery
- Where
- 2 sites in Sweden
- Volunteers
- 21 people
- Sponsor
- Anders Holmlund
Rheumatoid Arthritis (RA), Periodontitis
Effects of Nonsurgical Periodontal Treatment on GCF Calprotectin and IL-10 in Rheumatoid Arthritis
This study evaluates the relationship between rheumatoid arthritis and periodontal health and examines the effects of nonsurgical periodontal treatment on clinical periodontal findings and gingival crevicular fluid biomarkers.
- Conditions
- Rheumatoid Arthritis (RA), Periodontitis, Gingivitis
- Trial name
- NCT07844564
- Testing
- Non-surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periodontitis
Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.
With the increase in the incidence of diabetes and obesity, among other artificial sweeteners the need of natural non-caloric sweetener with acceptable taste and without any adverse effects is demanding.So,the use of stevia…
- Trial name
- NCT04381598
- Testing
- stevia rebaudiana bertoni
- Where
- India
- Volunteers
- 19 people
- Sponsor
- SVS Institute of Dental Sciences
Periodontal Pocket
The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic
The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal…
- Trial name
- NCT06669026
- Testing
- vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel, vitamin D3 gel (regular non-nanoparticle form), only mechanical debridement
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Effectiveness of Charcoal-infused Versus Nylon Bristle Toothbrushes on Plaque Removal and Oral Bacterial Reduction in Children
Plaque Removal in Children Using Charcoal and Nylon Toothbrushes
This study will compare two types of toothbrushes in children: a charcoal-infused bristle toothbrush and a regular nylon bristle toothbrush.
- Trial name
- NCT07563400
- Testing
- soft charcoal infused bristle toothbrush (iLive) with bamboo handle, soft nylon bristle toothbrush (Oral B JUNIOR 6-12)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
The Effect of Non-Surgical Periodontal Treatment on Bone Metabolism in Type 2 Diabetes and Systemically Healthy Individuals
In this study, it was concluded that sclerostin and irisin may be alternative markers for evaluating the effectiveness of periodontal treatment and healing of periodontal tissues by affecting bone metabolism.
- Trial name
- NCT05862311
- Testing
- ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis, Periodontal Diseases
Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response.
- Conditions
- Periodontitis, Periodontal Diseases, Smoking, Smoking, Tobacco
- Trial name
- NCT05281848
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gazi University
Obesity, Periodontal Diseases
Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy
Obesity and periodontitis are among the most common chronic disorders affecting the world population, while Prolactin (PRL) is a neuroendocrine hormone that within the physiological range stimulates bone formation while mild to…
- Trial name
- NCT07571850
- Testing
- Obese patients with stage II and III periodontitis and non surgical peridontal therapy, obese patients with healthy periodontium with no intervention
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University