Clinical trials: Gingival Diseases
Tobacco Dependence
Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
- Trial name
- NCT01368016
- Testing
- Nicotine
- Where
- 2 sites in Sweden
- Volunteers
- 346 people
- Sponsor
- McNeil AB
Gingival Inflammation, Plaque
Stannous Fluoride Toothpaste for Reduction and Treatment of Gingivitis
This study evaluated the efficacy of a stannous fluoride toothpaste compared to a sodium fluoride control toothpaste in reducing gingivitis, bleeding, and plaque over a 12-week period.
- Conditions
- Gingival Inflammation, Plaque, Bleeding
- Trial name
- NCT07640399
- Testing
- Sodium Fluoride Dentifrice, Stannous Fluoride Toothpaste (SnF)
- Where
- Canada
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Re-mineralization
Re-mineralization Effects of Sugar Free Chewing Gum Sweetened With Different Sugar-substitutes
The purpose of this study is to evaluate the clinical effect of chewing gum containing maltitol, on re-mineralization of early caries following daily chewing for 6 months by school children, compared to a xylitol gum, gum base…
- Trial name
- NCT02468388
- Testing
- maltitol, xylitol, gum base
- Where
- China
- Volunteers
- 482 people
- Sponsor
- Roquette Management (Shanghai) Co., Ltd.
Periodontitis, Plaque, Dental
Impact of Regular Home Use of Lumoral Dual-light Photodynamic Therapy on Plaque Control and Gingival Health
This early-stage study is designed to determine the efficacy of the CE-approved, antibacterial, dual-light Lumoral method in periodontitis patients.
- Conditions
- Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05361590
- Testing
- Lumoral device
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Gingivitis, Plaque
Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque
The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a positive control mouth rinse and a hydroalcohol control mouth rinse for the reduction of gingivitis and…
- Trial name
- NCT04921371
- Testing
- Colgate® Cavity Protection Toothpaste, Listerine® Cool Mint®, Concept Curve Winter Series Toothbrush
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Gingivitis
Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis
The aim of this study is to evaluate the efficacy of a new interdental cleaning device (Soft-Picks Advanced), as compared to a leading brand floss; and, how ease of use can promote the establishment of a hygienic routine of…
- Trial name
- NCT02883244
- Testing
- Soft-Picks Advanced, Floss
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sunstar Americas
Orthodontic Appliance Complication, Plaque, Dental
Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment
This study is designed to determine the efficacy of the Lumoral method on oral health in adolescents undergoing fixed orthodontic treatment.
- Conditions
- Orthodontic Appliance Complication, Plaque, Dental, Gingival Inflammation
- Trial name
- NCT05825742
- Testing
- Lumoral Treatment, Standard oral health instructions
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Gingival Inflammation in Diabetic Patients
Herbal Periodontal Patch (THPP) for Gingival Inflammation in Diabetics
Diabetes increases the incidence and severity of periodontal inflammation and disease, and periodontal disease causes an increase in the severity of diabetes by worsening glycemic control and increasing insulin resistance.The…
- Trial name
- NCT00731432
- Testing
- Transmucosal Herbal Periodontal Patch (THPP)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Izun Pharma Ltd
Plaque, Gingivitis
Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth
The clinical study will examine the effects of brushing with randomly assigned test toothpaste on the bacteria on the dental plaque, tongue, cheek, gum surface, and in saliva
- Trial name
- NCT07458464
- Testing
- stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- Where
- 2 sites in Thailand
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Gingivitis
A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation
The aim of this 24-week clinical study is to evaluate the ability of an experimental dentifrice containing 0.454 percent (%) weight by weight (w/w) Stannous fluoride (SnF2); to improve gingival health, plaque reduction and…
- Trial name
- NCT07255040
- Testing
- Test Dentifrice, Parodontax Complete Protection, Colgate Cavity Protection
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- HALEON
Dry Eye
Efficacy of Topical 0.2% Xanthan Gum in Patients With Dry Eye
The purpose of this study is to evaluate the effect of an ophthalmic solution containing 0.2% xanthan gum in reducing symptoms and signs of dry eye as well as tear film markers of oxidative stress.
- Trial name
- NCT01959854
- Testing
- carboxymethylcellulose, xanthan gum
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- SIFI SpA
Dental Plaque, Gingivitis
The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Available Fluoride Toothpaste in Reducing Plaque and Gingivitis
The objective of this study is to evaluate the clinical efficacy of a new toothpaste containing stannous fluoride (SnF) as compared to Colgate Fluoride Toothpaste in reducing gingivitis and dental plaque.
- Trial name
- NCT03852056
- Testing
- MFP Fluoride toothpaste, Stannous fluoride toothpaste
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Gingivitis and Periodontal Diseases
Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Plaque and Gingivitis
This is a Phase III, one-center, parallel group, double blind, clinical study to evaluate the effect of a toothpaste containing 0.3% chlorhexidine in subjects with established dental plaque and gingivitis.
- Conditions
- Gingivitis, Gingivitis and Periodontal Diseases, Gingival Disease, Dental Plaque
- Trial name
- CHX TP (NCT06732466)
- Testing
- Chlorhexidine toothpaste, Toothbrush
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Colgate Palmolive
No Disease State or Condition
Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT03233737
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Dental Plaque, Gingivitis
A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
The aim of this study is to assess the ability of a marketed Cetylpyridinium Chloride (CPC) mouthwash alongside a marketed Stannous Fluoride (SnF2) toothpaste in improving gingival health and reducing plaque accumulation…
- Trial name
- NCT06660069
- Testing
- Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste), CPC Mouthwash (Parodontax Active Gum Health Mouthwash), Regular Fluoride Toothpaste (Crest Cavity Protection)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- HALEON
Post-Dental Gingival Pain, Gingival Swelling
Efficacy and Safety of HA35 Gel for Post-Dental Gingival Pain and Swelling
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of 10% high-concentration 35 kDa hyaluronan (HA35) gel delivered via gel-soaked cotton balls in patients with gingival pain…
- Conditions
- Post-Dental Gingival Pain, Gingival Swelling, Postoperative Oral Pain, Dental Procedure-Related Discomfort
- Trial name
- HA35 (NCT07584655)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Oral Topical Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Gingivitis
Compare Anti-inflammatory Dentifrices
Plaque induced gingivitis
- Trial name
- NCT00762528
- Testing
- Triclosan/Copolymer/fluoride toothpaste, Sodium monofluorophosphate toothpaste
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Diseases
Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Clinical research study to determine the anti-plaque efficacy of prototype dentifrices via a 4-day brushing regiment
- Trial name
- NCT00966953
- Testing
- Fluoride, Triclosan/Fluoride toothpaste, antibacterial plant extract
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Plaque, Dental
Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas
The objective of this study is to evaluate the efficacy of a eugenol-based product in improving the quality of toothbrushing and relieving areas of gingival discomfort.
- Trial name
- NCT06366568
- Testing
- fluoride toothpaste containing 1450 ppm of MFP in a PCC base and eugenol gum product, fluoride toothpaste containing 1450 ppm of MFP in a PCC base
- Where
- Germany
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Tobacco Dependence
Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum
Single-dose pharmacokinetics with two new oral nicotine replacement products and Nicorette® gum.
- Trial name
- NCT01152723
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- McNeil AB