Clinical trials: Gingival Inflammation
Periodontal Disease, Periodontitis
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis
Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.
- Trial name
- PRFperio (NCT06920849)
- Testing
- SRP+iPRF, SRP
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Pulpitis, Healthy
Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls
This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.
- Trial name
- SMART-PULP (NCT07450235)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Université de Nantes
Periodontitis, Gingivitis
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression
T Regulatory cells which suppressor subset of T cells and related cytokines remain in blood and infiltrates into the tissue under need.
- Trial name
- NCT06135116
- Testing
- Flow Cytometric Detection of Regulatory T Cells and Cytokines analysis by ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Gingivitis, Periodontitis
The Impact of Non-surgical Periodontal Therapy on Patients' Halitosis, Taste Perception, and Smell Sensation
The goal of this observational study is to evaluate the effect of non-surgical periodontal treatment on patient halitosis, smell, and taste perception in gingivitis and periodontitis patients.
- Trial name
- NCT06063460
- Testing
- Periodontal examination, baseline questionnaire about sociodemographic characteristics, smoking habits, oral hygiene habits, halitosis, smell and taste perception, phase I periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Necmettin Erbakan University
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Gingivitis, Plaque, Dental
Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of…
- Trial name
- NCT06300866
- Testing
- Test, Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontal Inflammation, Alveolar Bone Loss
The Effect of Non-surgical Periodontal Treatment on Dickkoff-1 and Secreted Frizzled Related Protein-5 Levels
Periodontitis is a condition that is defined by microbial-associated, host-induced inflammation, which ultimately results in the loss of periodontal attachment.Periodontal clinical parameters are the most reliable indicators of…
- Conditions
- Periodontal Inflammation, Alveolar Bone Loss, Periodontal Diseases
- Trial name
- NCT06727929
- Testing
- Collection of gingival crevicular fluid, ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Gingivitis
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
- Trial name
- NCT06507280
- Testing
- Periodontal theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Dental Plaque, Gingivitis
A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation
The aim of this 24-week clinical study is to evaluate the ability of an experimental dentifrice containing 0.454 percent (%) weight by weight (w/w) Stannous fluoride (SnF2); to improve gingival health, plaque reduction and…
- Trial name
- NCT07255040
- Testing
- Test Dentifrice, Parodontax Complete Protection, Colgate Cavity Protection
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Plaque, Side Effects
Clinical Effects of Two New Chlorhexidine Digluconate Formulations: 0.12% and 0.03%.
In the current study we tested the hypothesis that new 0.05% Cetylpyridinium chloride (CPC) mouthrinse formulations containing 0.12% or 0.03% chlorhexidine digluconate (CHX): 1) yield similar or better clinical results regarding…
- Trial name
- NCT02194023
- Testing
- 0.12%NF, 0.03%NF, PAT
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Dental Plaque, Gingivitis
Essential Oil+ELA, Plaque and Gingivitis
A commercially available mouth rinse with ethyl lauroyl arginate and essential oils claims to have enhanced antimicrobial properties as compared to the traditional essential oil products.
- Trial name
- NCT02884817
- Testing
- Experimental: essential oils and ELA, Water
- Where
- Norway
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Periodontitis, Gingivitis and Periodontal Diseases
Salivary Free Amino Acid Profiles in Periodontitis: Associations With Clinical Parameters and Dynamic Responses to Non Surgical Therapy
# Brief Summary (Word count: 198) This combined observational and interventional study investigates salivary amino acid profiles and their connections to periodontal conditions, as well as how these substances change after…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Periodontal Debridement, Periodontal Attachment Loss
- Trial name
- FAA-CP-SRP (NCT07669233)
- Testing
- Non-surgical periodontal therapy
- Where
- China
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Zhang, Yuwei
Dental Devices, Home Care
Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis
This study is 6 weeks long with 6 visits to a clinical site. People participating in this study will be asked to brush their teeth two times a day with a provided toothbrush.
- Trial name
- NCT01224158
- Testing
- Experimental Power Toothbrush, Flat trimmed Manual Toothbrush
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Periodontal Diseases
Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome
Emerging research indicates a link between polycystic ovary syndrome (PCOS) and periodontal diseases, revealing the intricate relationship between oral health and systemic conditions.
- Trial name
- NCT06184412
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Gingival Inflammation
Lactobacillus Reuteri Strains for Gingivitis Reduction
The aim of the present study was to investigate the potential beneficial effects in volunteer young adults of orally administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation.
- Trial name
- NCT06234839
- Testing
- L. reuteri (DSM 17938 and ATCC PTA 5289) in form of oral tablets
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Periodontal Diseases
Analysis of Gingival Crevicular Fluid
The purpose of this study was to investigate and compare GCF interleukin-1β (IL-1β), interleukin-10 (IL-10), interleukin-36γ (IL-36γ) levels in patients with healthy (H), gingivitis (G) and chronic periodontitis (CP) status.
- Trial name
- GCF (NCT05325905)
- Testing
- Gingival crevicular fluid sampling
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Gingivitis
Clinical Effect of Lactobacillus Reuteri in Treatment of Gingivitis
The aim of this randomized placebo- controlled clinical trials is to evaluate the effects of Lactobacillus reuteri containing probiotic lozenges as an adjunct to scaling and root planning (SRP).
- Trial name
- NCT02801773
- Testing
- Treatment Gingivitis with Probiotic, Treatment Gingivitis conventional
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- University of Chile
Periodontitis, Gingivitis
Meteorin-like Levels in Individuals With Periodontitis
Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl is highly expressed from the oral mucosa to the esophagus.
- Conditions
- Periodontitis, Gingivitis, Healthy
- Trial name
- NCT04402996
- Testing
- Saliva, gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Dental Plaque
Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children
The objective of this single-use, examiner blinded, randomized, two-period, cross-over, IRB-approved clinical study is to evaluate the safety and plaque removal efficacy of AutoBrush®, a new children's 360° sonic toothbrush…
- Trial name
- NCT06300073
- Testing
- Experimental: U-shaped Power Toothbrush
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Lander Enterprises, LLC