Clinical trials: Glaucoma, Open Angle
Primary Open Angle Glaucoma
The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients
To quantify oxidative stress in circulating leukocytes of normal tension glaucoma patients, prior to and one month after routine vascular therapy.
- Trial name
- NCT00465348
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cataract, Primary Open-angle Glaucoma
Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction
Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)
- Trial name
- NCT03889652
- Testing
- Oct scans
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
To See the Safety and Efficacy of the Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma Patients
The Effectiveness of Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma
Outpatient department of cmch, ceitc,cimch POAG patients enrolled for the study.
- Trial name
- NCT04205201
- Testing
- Drugs, Investigational
- Where
- 2 sites in Bangladesh
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chittagong Medical College
Glaucoma
Will Listening to Music Make it Easier to Take a Visual Field Test?
The purpose of this study is to examine if there is a difference between glaucoma patients having background music and not having background music before visual field testing.
- Trial name
- NCT01027039
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Glaucoma Open-Angle Primary, Glaucoma
Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy
In this Pilot explorative study, the investigators are going to estimate and compare the outcomes of three different delivery methods of MMC for Trabeculectomy: a subconjunctival injection of MMC 0.002% at the site of future…
- Conditions
- Glaucoma Open-Angle Primary, Glaucoma, Open Angle Glaucoma, Glaucoma, Open-Angle
- Trial name
- NCT03875911
- Testing
- Mitomycin C
- Where
- 4 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG)
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
- Conditions
- Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG), Dry Eye Disease (DED), Keratoconus
- Trial name
- NCT07780890
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Glaucoma Open-Angle Primary
OCTA Study of Choroidal Vasculature in Open Angle Glaucoma Patients
The aim of the present study was to examine and measure SFCT and CCVD using respectively EDI-OCT and OCTA in preperimetric and advanced glaucomatous eyes, in order to shed light on the vascular pathogenesis of glaucoma disease.
- Trial name
- NCT05455567
- Testing
- OCTA
- Where
- Italy
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Federico II University
Primary Open-angle Glaucoma
Efficacy and Tolerability of Preservative-free 0.0015% Tafluprost in Glaucoma Patients
The aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost.
- Trial name
- NCT03104621
- Testing
- Benzalkonium chloride (BAK), 0.0015% tafluprost
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Glaucoma, Primary Open Angle, Cataract
Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert
Randomized, controlled treatment with an intracanalicular dexamethasone (0.4mg) insert following cataract surgery with intraocular lens implant (IOL) combined with minimally invasive glaucoma surgery (MIGS), specifically iStent…
- Trial name
- NCT04465864
- Testing
- Intracanalicular Dexamethasone, 0.4 mg insert
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wolstan and Goldberg Eye Associates
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Advanced Glycation End Products as a Biomarker for Accelerated Ageing
Globally primary open angle glaucoma (POAG) affects over 60 million people. The exact pathogenesis of POAG is poorly understood. A significant risk factor for glaucoma is advancing age.
- Conditions
- Primary Open Angle Glaucoma, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT02863224
- Where
- United Kingdom
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Primary Open-angle Glaucoma (POAG)
Role of Peripheral Vision in Scene Perception (PERISCE)
Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the…
- Trial name
- PERISCE (NCT05539508)
- Testing
- Psychophysical evaluation
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Glaucoma, Intraocular Pressure
The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops
Pediatric glaucoma is a rare but potentially blinding condition where the pressure in the eye is too high. Diagnosis is based on intraocular pressure (IOP) and assessment of the optic nerve, cornea and other structures.
- Conditions
- Glaucoma, Intraocular Pressure, Anesthesia
- Trial name
- IOP (NCT01925391)
- Testing
- Tono-pen XL Applanation tonometer + Ocu-film +
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Exfoliation Syndrome
Central Corneal Thickness in Glaucoma
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate…
- Trial name
- NCT01023997
- Where
- Greece
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Primary Open Angle Glaucoma
Comparison of Retinal Nerve Fiber Layer (RNFL) Thickness Measurements by Time-Domain and Spectral-Domain OCT In Glaucoma Patients
Measurement of RNFL thickness by OCT is at a cornerstone for the correct diagnosis and monitoring of progression of glaucomatous optic neuropathy.
- Trial name
- NCT00773877
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Macular Degeneration, Glaucoma
An Open Study Comparing the Effects of Moxaverine on Ocular Blood Flow in Patients With Age- Related Macular Degeneration, Primary Open Angle Glaucoma and Healthy Control Subjects
A number of common eye diseases such as age-related macular degeneration and glaucoma are associated with ocular perfusion abnormalities.
- Conditions
- Macular Degeneration, Glaucoma, Regional Blood Flow
- Trial name
- NCT00709449
- Testing
- moxaverine
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma, Open-Angle
A Comparison of Cataract Surgery Alone and Cataract Surgery With iStent
This study aims to recruit patients of the Glaucoma Investigative and Research Unit (GIRU) of Royal Victorian Eye and Ear Hospital (RVEEH) with mild to moderate glaucoma who are due to undergo cataract surgery and randomise each…
- Trial name
- NCT03106181
- Testing
- iStent inject®, Phacoemulsification and intraocular lens implant
- Where
- Australia
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Royal Victoria Eye and Ear Hospital
Glaucoma, Open-Angle, Ocular Hypertension
Intraocular Pressure With Loteprednol and Dexamethasone
The purpose of this study is to compare intraocular pressure (IOP) changes after pterygium surgery among patients using loteprednol and dexamethasone during the postoperative period.
- Trial name
- NCT00781300
- Testing
- Loteprednol Etabonate 0.5%, Dexamethasone 0.1%
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Glaucoma
Posterior Cornea in Primary Open Angle Glaucoma
Characterization of posterior corneal changes in primary open angle glaucoma patients, using Scheimpflug examination.
- Trial name
- NCT02356094
- Testing
- Pentacam
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar do Baixo Vouga
Open-Angle Glaucoma, Ocular Hypertension
A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma
Hypothesis: H1: Efficacy of Duotrav will be superior to Xalacom at 24 hours post dosing when both medications are given in the morning H2: A significant proportion of patients will prefer dosing of once daily topical fixed…
- Trial name
- DVX (NCT00887029)
- Testing
- DuoTrav (travoprost-timolol ophthalmic drops), Xalacom (latanoprost-timolol ophthalmic drops)
- Where
- 2 sites in Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants Centres, Canada