Clinical trials: Glaucoma Patients
Primary Open-angle Glaucoma
Impact of Glaucoma and Visual Field Loss on Life Space
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT03673644
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Alabama at Birmingham
Primary Open Angle Glaucoma
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT04396002
- Testing
- Life Space Questionnaire, Low Luminance Questionnaire, Contrast sensitivity under dim illumination
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Glaucoma
Determining the Clinical Utility of Using Virtual Reality Headsets to Assess Visual Function in Those With Glaucoma.
To validate a new virtual reality (VR) based visual field test against the gold standard clinical perimetry test (Humphrey Visual field test 24-2).
- Trial name
- NCT04273438
- Testing
- Visual field testing using Oculus Rift and Humphrey Visual Field Perimeter, Visual Field Testing using HUmphrey 24-3 Perimeter
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Queen's University, Belfast
Deep Sclerectomy With Trabeculotomy in Advanced Glaucoma
Short-Term Efficacy and Safety of Combined Deep Sclerectomy With Trabeculotomy in Advanced Glaucoma: A Prospective Interventional Study
Brief Summary Glaucoma is a progressive eye disease that can lead to irreversible vision loss if intraocular pressure (IOP) is not adequately controlled.
- Trial name
- NCT07895537
- Testing
- Combined Deep Sclerectomy with Trabeculotomy
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Minia University
Corneal Transplantation, Glaucoma
Timing of Glaucoma Drainage Device With Boston Keratoprosthesis
Boston keratoprosthesis (KPro) is a piece of specialized plastic that replace sick cornea (transparent structure at the front of the eye) in patients who have failed or those who are expected to have poor results with traditional…
- Trial name
- GDD-KPro (NCT02084745)
- Testing
- Boston keratoprosthesis type 1, Glaucoma drainage device
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Glaucoma
VGFTe-(HD)-OD-2566: Adjunctive Aflibercept Ahmed Glaucoma Valve (AAA) Study
The purpose of this study is to determine if injections of aflibercept into the eye given at the end of the Ahmed tube surgery as well as at postoperative months one and two would improve eye pressure control compared to standard…
- Trial name
- NCT07891182
- Testing
- Aflibercept Injection, Ahmed Tube Surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Macular Degeneration, Diabetic Retinopathy
Iopidine to Decrease Intraocular Pressure Rise After Injections
This is a prospective, randomized, controlled, open-label, single-site investigator-initiated clinical trial. A total of 120 participants will be randomized in a 1:1 ratio either to receive one drop of apraclonidine 1% ophthalmic…
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion, Glaucoma
- Trial name
- NCT07891910
- Testing
- Apraclonidine 1.0% ophthalmic solution
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Retina Consultants of Delmarva
Non-infectious Anterior Uveitis, Uveitic Glaucoma
TRS4Vision - A Study of TRS01 in Subjects With Active Non-infectious Anterior Uveitis Including Subjects With Uveitic Glaucoma
The primary objective of this study is to evaluate the efficacy and safety of TRS01 eye drops compared to active comparator in subjects with active non-infectious anterior uveitis with or without uveitic glaucoma
- Trial name
- NCT05042609
- Testing
- TRS01, FDA approved steroid eye drop (masked)
- Where
- 30 sites in United States, France and 1 more
- Volunteers
- 142 people
- Sponsor
- Tarsier Pharma
Glaucoma
A Study Evaluating the Safety and Efficacy of MINIject S+ in Subjects With Open Angle Glaucoma
This is a prospective, multi-center, international, cohort expansion study. Part 1 will be conducted in subjects with open angle glaucoma to identify the best insertion tool for MINIject S+.
- Trial name
- STAR VII (NCT07009236)
- Testing
- MIGS
- Where
- 5 sites in Honduras, United Kingdom
- Volunteers
- 60 people
- Sponsor
- iSTAR Medical
Glaucoma
A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage
Open-angle glaucoma is the most common type of glaucoma, a disease that damages the nerves in the eye and can lead to vision loss. Current treatments include eye drops, laser treatment, and surgery that help lower eye pressure.
- Trial name
- NCT07770685
- Testing
- ASP2767, Prophylactic Regimen A, Prophylactic Regimen B
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Glaucoma
Topical Insulin for Glaucoma
The purpose of this Phase 1 trial is to determine the safety over 1-2 months of topic sterile human recombinant insulin on subjects with optic neuropathies (glaucoma, ischecmic optic neuropathy, and optic disc drusen).
- Trial name
- TING1 (NCT05206877)
- Testing
- Insulin, 4 units, Insulin, 20 units, insulin, 4 units twice daily
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Stanford University
Neovascular Glaucoma
Efficacy and Safety of Minimally Invasive Suprachoroidal Drainage
This study primarily involved a retrospective analysis of clinical and follow-up data from patients with advanced neovascular glaucoma who underwent minimally invasive suprachoroidal drainage surgery at the Department of…
- Trial name
- NCT07882511
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Primary Open Angle Glaucoma
OMNI 3.1 Surgical System in Subjects With Primary Open-Angle Glaucoma
To gain early evidence of safety and assess the effectiveness of the intraocular pressure (IOP)-lowering effectiveness of the OMNI 3.0 Surgical System in primary open-angel glaucoma (POAG).
- Trial name
- NCT06991270
- Testing
- OMNI 3.0 Surgical System
- Where
- Panama
- Volunteers
- 25 people
- Sponsor
- Sight Sciences, Inc.
Glaucoma, Primary Open Angle
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed.
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed.
- Trial name
- NCT07880132
- Testing
- GORE Glaucoma Drainage Implant
- Volunteers
- 70 people
- Sponsor
- Gore Ophthalmic
Glaucoma, Vision Impairment and Blindness
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
The investigators are conducting a 5-year prospective, 2:1 cluster-randomized controlled trial, funded by the Centers for Disease Control (CDC), which provides vision screenings to underserved New York City residents living in…
- Conditions
- Glaucoma, Vision Impairment and Blindness, Cataract, Diabetic Retinopathy
- Trial name
- NCT04271709
- Testing
- Enhanced Intervention Using Patient Navigators, Usual Care
- Where
- United States
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Columbia University
Glaucoma
Morphometric Markers of the Effectiveness of Micropulse Cyclophotocoagulation
This prospective study aims to evaluate morphometric markers of treatment response following micropulse transscleral cyclophotocoagulation (MP-CPC) in patients with glaucoma.
- Trial name
- MMEMC (NCT07592923)
- Testing
- MicroPulse transscleral cyclophotocoagulation, Conventional transscleral cyclophotocoagulation
- Where
- Kazakhstan
- Volunteers
- 20 people
- Sponsor
- Kazakh Eye Research Institute
Glaucoma
Tear Interleukin Biomarkers After Glaucoma Treatment
This prospective study aims to evaluate inflammatory biomarkers in tear fluid in patients with glaucoma undergoing micropulse transscleral cyclophotocoagulation (MP-CPC), continuous-wave cyclophotocoagulation (CPC), and…
- Trial name
- TIGT (NCT07592988)
- Testing
- MicroPulse Transscleral Cyclophotocoagulation, Conventional Transscleral Cyclophotocoagulation, Antiglaucoma Surgery
- Where
- Kazakhstan
- Volunteers
- 24 people
- Sponsor
- Kazakh Eye Research Institute
Open Angle Glaucoma
Inferonasal MIMS® Procedure: Long-Term Follow-Up Extension Study
A long-term (24 and 30 months) follow-up extension, prospective, non-interventional, open label study for data collection from subjects who underwent prior MIMS® inferonasal surgery, in continuation of the previous clinical…
- Trial name
- NCT06577857
- Testing
- Inferonasal Minimally Invasive Micro Sclerostomy
- Where
- Armenia
- Volunteers
- 44 people
- Sponsor
- Sanoculis Ltd
Open Angle Glaucoma
MIMS® Retrospective Chart Review
This is a post-market clinical follow-up, retrospective chart review of MIMS® surgical procedures conducted during time period between Sep 2023 and April 2025.
- Trial name
- NCT06614218
- Testing
- Minimally Invasive Micro Sclerostomy
- Where
- Armenia
- Volunteers
- 34 people
- Sponsor
- Sanoculis Ltd