Clinical trials: Glaucoma and Ocular Hypertension
Glaucoma
The Aim of This Study is to Investigate the Correlation Between the Severity of Glaucoma and Corneal Biomechanics as Well as Anterior Chamber Parameters.
The ocular biomechanical differences between the normal control group and primary glaucoma patients, including those treated with conventional medication, laser therapy, and surgery, were compared.
- Trial name
- NCT06340061
- Testing
- Observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Glaucoma, Glaucoma, Open-Angle
Treatment Outcomes of MicroPulse Trans-scleral Cyclophotocoagulation in Uncontrolled Glaucoma
The goal of this study is to evaluate the efficacy and safety of the novel form of trans-scleral cyclophotocoagulation using micropulse diode laser and trans-pars plana treatment (Micropulse TSCPC, mTSCPC MP3, IRIDEX CYCLO G6™…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Neovascular, Glaucoma and Ocular Hypertension
- Trial name
- NCT03187418
- Testing
- MicroPulse® P3 Glaucoma Device (MP3)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Primary Glaucoma, Glaucoma Suspect
Development of the Glaucoma Visual Functioning Questionnaire-40 and Its Psychometric Properties
The objective of this study is to develop and test the psychometric properties of a self-report questionaire, the Glaucoma Visual Functioning Questionnaire-40 (GVFQ-40), which was designed to measure the difficulty of daily…
- Trial name
- NCT04722861
- Testing
- GVFQ-40
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)
Background Glaucoma is a multifactorial, chronic, and progressive eye disease characterized by the irreversible loss of retinal ganglion cells (RGCs).
- Trial name
- NCT07006194
- Testing
- Nicotinamide Tablet
- Where
- 3 sites in Italy
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Diabetic Macular Edema, Branch Retinal Vein Occlusion
EffiCacy, Safety and ToLErability of a Novel Ocular ANtiseptic for Ocular Use (CLEAN)
This is a randomized, double-masked, multicenter, study to evaluate the efficacy, safety, and tolerability of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Conditions
- Diabetic Macular Edema, Branch Retinal Vein Occlusion, Glaucoma/Closed Angle Glaucoma
- Trial name
- CLEAN (NCT05127525)
- Testing
- IRX-101, Control
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Open Angle Glaucoma, Normal Tension Glaucoma
Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins
Retinal ischemia is thought to play an important role in the pathogenesis of glaucoma. Recent findings have confirmed that there is a direct correlation between the levels of venous oxygen saturation and the degree of the…
- Trial name
- NCT01794442
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Physiology
Effects of Intravenous Clonidine on Ocular Blood Flow and Intraocular Pressure
Background Clonidine, a derivate of Imidazol, is an antihypertensive drug. It acts by stimulating adrenergic receptors on nerves in the brain and Imidazol-receptors.
- Trial name
- NCT00279253
- Testing
- clonidine (drug) intravenously
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
"First-in-human" Study To Assess the Safety and Tolerability of PBF-677 in Healthy Volunteers
The proposed trial a "Randomized, Double Blind, Placebo Controlled "first in-human" Study to Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-677 in Male Healthy Volunteers" (Protocol Code No:CUNFI-1509…
- Trial name
- NCT02639975
- Testing
- PBF-677
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Palobiofarma SL
Glaucoma, Healthy
Quantification of Agreement and Variability of a Newly Developed Visual Field Algorithm With the Reference Standard
This study aims to compare two types of visual field test; retinal sensitivity values obtained with the reference standard Swedish Interactive Thresholding Algorithm (SITA) of the standard visual field test and with a newly…
- Trial name
- vFAST (NCT02727569)
- Testing
- New visual field algorithm with DLS, SITA algorithm, New visual field algorithm with MMDT
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Glaucoma,Primary Open-Angle ,Primary Angle Closure
Comparison of Optical Coherence Tomography Angiography Microvascular Changes in Primary Open Angle and Primary Angle Closure Glaucoma
This work aims to study the peripapillary and macular microvascular changes in primary open angle and primary angle closure glaucoma using Optical Coherence Tomography Angiography (OCTA).
- Trial name
- NCT06000176
- Testing
- Optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Omar Said
Glaucoma, Retinal Pathology
Ability of Patients With Low Vision to Properly Instill Eye Drops
The investigators are interested in seeing how people with low vision (decreased visual acuity or restricted visual fields) instill eye drops into their own eyes.
- Trial name
- NCT00760240
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mid-Atlantic Glaucoma Experts
Glaucoma, Dry Eye Syndrome
Eye Drop Use in Glaucoma Patients Through Patient Surveys and Video Observations
This study will be used to evaluate how patients put eye drops in their eyes and any problems that may arise from this activity.
- Conditions
- Glaucoma, Dry Eye Syndrome, Conjunctivitis
- Trial name
- NCT00522600
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Diabetic Retinopathy, Glaucoma
Evaluation of The Performance of Retinow AI Software
Eye diseases are a major public health problem worldwide and one of the main causes of vision loss. Diseases such as diabetic retinopathy, glaucoma and macular degeneration in particular can lead to serious vision loss and…
- Conditions
- Diabetic Retinopathy, Glaucoma, Macular Degeneration
- Trial name
- NCT06645964
- Where
- Turkey (Türkiye)
- Volunteers
- 915 people, healthy volunteers welcome
- Sponsor
- Retinow Health Technologies and R&D Industry Joint Stock Company
Glaucoma, Optic Neuropathy, Ischemic
Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases
In the management of glaucoma, as for as in other optic nerve diseases, an important goal of ophthalmologists is represented by the possibility of influencing visual function.
- Conditions
- Glaucoma, Optic Neuropathy, Ischemic, Visual Pathway Disorder, Optic Nerve
- Trial name
- NCT00404729
- Testing
- Citicoline
- Where
- 2 sites in Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Primary Open Angle Glaucoma
Electroretinogram and Retinal Vascular Changes After Cataract Surgery
To compare electrophysiological and Optical coherence tomography angiography of optic disc and macula changes after uneventful phacoemulsification between normal and cataractus patients with primary open angle glaucoma.
- Trial name
- NCT05871034
- Testing
- phacoemulsification
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Healthy Eyes, Eye Diseases
Triton Agreement and Precision Study
To Compare the agreement and precision between the Topcon DRI OCT Triton and the 3D OCT-1 Maestro with RDB.
- Trial name
- NCT03080714
- Testing
- Topcon DRI OCT Triton (plus), 3D OCT-1 Maestro
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Glaucoma, Glaucoma, Angle-Closure
Macular Pigment Optical Density in Primary Angle-closure Disease
Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia.
- Conditions
- Glaucoma, Glaucoma, Angle-Closure, Macular Pigment Optical Density
- Trial name
- NCT05251792
- Testing
- Ocular examination
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Open Angle Glaucoma, Ocular Hypertension
PSLT Compared to Prostaglandin Analogue Eye Drops
This study aims to compare the efficacy of PSLT and the topical use of prostaglandin-like hypotensive eye drops in the treatment of ocular hypertensive or glaucomatous patients in decreasing intraocular pressure and measuring…
- Trial name
- NCT05241938
- Testing
- PSLT, Prostaglandin analogue eye drops
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Open Angle Glaucoma
Does the Optic Disc Grading Done Visually by Your Doctor Agree With Optic Nerve Testing Which is Done by Machines?
The purpose of this study is to determine how well the DDLS (Disc Damage Likelihood Scale) (which is a method used by the eye doctor to evaluate how healthy the optic nerve is) measures up to the standard glaucoma tests: OCT…
- Trial name
- NCT00430287
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Wills Eye
OAG - Open-Angle Glaucoma, OHT - Ocular Hypertension
Study Comparing the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density and Visual Acuity
The purpose of this research study is to compare the effect of Latanoprostene Bunod and Timolol on eye pressure and blood vessels of the back of the eye.
- Trial name
- NCT03931317
- Testing
- Latanoprostene bunod 0.024% QD, Timolol maleate 0.5% BID
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego