Clinical trials: Global Surgery
Postoperative Quality of Recovery
Validation of the German Quality of Recovery-15 Questionnaire
The Quality of Recovery 15-questionnaire (QoR-15) is used to assess postoperative quality of recovery after surgery and anesthesia from the patient's perspective.
- Trial name
- NCT04528524
- Testing
- Questionnaire
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Marlene Fischer
Elective Surgical Patient, Hypertensive Patients
Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients
Dexmedetomidine, an alpha-2 adrenergic agonist, has been shown to provide several benefits during endotracheal intubation: 1. _Reduced anxiety and stress_: Dexmedetomidine's anxiolytic and sedative effects help reduce anxiety and…
- Conditions
- Elective Surgical Patient, Hypertensive Patients, Blood Pressure, Hypertensive Elderly Patients
- Trial name
- NCT06712186
- Testing
- Dexmedetomidine Group / Group D
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Liaquat National Hospital & Medical College
Anesthesia, General
Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Required General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on Cardiovascular System in Common Clinical Practice
The main objective of this post-marketing observational study is to collect data from the use of general anesthesia in patients undergoing any surgery to create local recommendations.
- Trial name
- SEVOPROTECTION (NCT01282203)
- Where
- 12 sites in Kazakhstan
- Volunteers
- 1,122 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Emergency General Surgery
Robotic Emergency General Surgery Program
Background Abdominal surgical emergencies account for 20-30% of visceral surgery procedures. However, these emergencies are responsible for more than half of the morbidity in our discipline, with a surgical site infection rate…
- Trial name
- NCT07202442
- Testing
- Emergency General surgery patients with robotic approach for the surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Failure to Rescue, Emergencies
Rescue for Emergency Surgery Patients Observed to uNdergo Acute Deterioration
This is a Five Year programme designed to identify and evaluate human factors interventions to improve the response to patients deteriorating following emergency surgery.
- Trial name
- RESPOND (NCT04919720)
- Testing
- FRAM Model and Human Factors/Quality Improvement Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 9,064 people
- Sponsor
- University of Oxford
Anesthesia, Obesity
Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients
Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.
- Trial name
- NCT03417518
- Testing
- Desflurane Inhalant Product, Propofol
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Opioids, Clinical Trial
The Comparative Efficacy and Safety of Two General Anesthesia Protocols Consisting of Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane for Gynaecology Surgery in Cameroon
Recently, a lot of side effects have been identified from the perioperative use of opioids. To remedy this, anesthesia research has recently focused on providing safe general anesthesia without opioids in a new concept or…
- Conditions
- Opioids, Clinical Trial, Anesthesia, Gynecology
- Trial name
- OFA-AFRO (NCT04737473)
- Testing
- Opiod Free Anesthesia
- Where
- Cameroon
- Volunteers
- 36 people
- Sponsor
- University of Yaounde 1
Surgical Procedure, Unspecified
Lung Expansion Technics on Chest Wall Mechanics and Preventing Pulmonary Complication After Abdominal Surgery
The lung expansion techniques are widely used to prevent postoperative pulmonary complications. However, the effect of each technique on thoracoabdominal mechanics after abdominal surgery and if it influences the rate of…
- Trial name
- NCT01993602
- Testing
- Breathing exercises
- Where
- Brazil
- Volunteers
- 171 people
- Sponsor
- University of Sao Paulo General Hospital
Laparoscopic General, Gynecological and Urologic Surgeries
Evaluation of the Sevoflurane Consumption During General Anesthesia When Using the MemsorbTM Membrane
The study aims at determining whether replacing the classical chemical absorber Dräegersorb 800+ on Dräeger Perseus A500 machines (Dräeger, Lübeck, Germany) by the new membrane technology-based product (Memsorb™, DMF Medical…
- Trial name
- MEMSEV (NCT04539405)
- Testing
- To evaluate sevoflurane consumption when using Memsorb, To evaluate sevoflurane consumption when using classical Dräegersorb
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Polypharmacy, General Surgery
Polypharmacy and Associated Risk Factors and Clinical Outcomes for Surgical Patients Discharged From Hospital
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT04805151
- Testing
- No intervention
- Where
- Iceland
- Volunteers
- 56,000 people
- Sponsor
- University of Iceland
Medical Education, Gamification
The Effectiveness of Gamification vs. Traditional Teaching in Undergraduate Medical Education
This study will evaluate the effectiveness of a gamification-based learning method (board game) versus traditional teaching (lecture) in enhancing the knowledge of acute cholecystitis and pancreatitis among medical students in…
- Trial name
- NCT06763627
- Testing
- Gamification ( Board game ), Traditional lecture-based teaching
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Iran University of Medical Sciences
Hemodynamic Instability, Postoperative Recovery
Subanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients
This retrospective study evaluated the effects of a subanesthetic dose of esketamine (0.25 mg/kg) on intraoperative hemodynamic stability and postoperative recovery quality in elderly patients (aged 65-75) undergoing thoracic…
- Conditions
- Hemodynamic Instability, Postoperative Recovery, Thoracic Surgery, Anesthesia, General
- Trial name
- NCT07064408
- Testing
- Esketamine, Normal Saline (0.9% Sodium Chloride), Midazolam
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Hebei Medical University Fourth Hospital
Intubation; Difficult
Study of Interest on Cervical Ultrasound Exploration for Association With Difficult Intubation
The purpose of this study is to determine if cervical ultrasound exploration can predict difficult intubation better than main validated clinical criteria.
- Trial name
- TUBECHO (NCT02362568)
- Testing
- Ultrasound cervical exploration
- Where
- 2 sites in France
- Volunteers
- 462 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Stress Related Disorder
Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries
assessing the effect of perioperative infusion of Dexmedetomidine versus Lidocaine on neuro endocrine stress response to surgery and anesthesia
- Trial name
- Adjuvant (NCT03600493)
- Testing
- Dexmedetomidine, Lidocaine
- Volunteers
- 64 people
- Sponsor
- Suez Canal University
Oral Surgical Procedures, Surgery, Oral
Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Anxious Patients
Whether patient-maintained sedation (the patient controls his/her degree of sedation using a hand-held device) using the drug propofol is safer and more effective when using deteriorating reaction time as an added safeguard…
- Conditions
- Oral Surgical Procedures, Surgery, Oral, Dental Anxiety, Surgery
- Trial name
- NCT00355693
- Testing
- Pump for propofol delivery
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Anesthesia
High Flow Oxygen in Patients Undergoing Surgery Under General Anesthesia
Preoxygenation remains an important determinant of morbidity and mortality in anesthesia despite advances in mask ventilation and difficult intubation management. 1.
- Trial name
- OPTIFLOW (NCT03554863)
- Testing
- Nasal High Flow Oxygen, Facial Mask
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- CMC Ambroise Paré
Hypotension
TAPSE/PASP Anesthesia
TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function.
- Trial name
- TAPSE/PASP (NCT06237543)
- Testing
- hypotension
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Aydin Adnan Menderes University
Hypothermia Following Anesthesia, Intraoperative Complications
Goal-Directed Temperature Management During Prolonged Abdominal Surgery
During long operations on the abdomen, patients often get cold. Doctors call this perioperative hypothermia. Even a small drop in body temperature can cause problems, such as more bleeding, wound infection, and a longer stay in…
- Conditions
- Hypothermia Following Anesthesia, Intraoperative Complications, Body Temperature Changes, Anesthesia, General
- Trial name
- NCT07854704
- Testing
- Forced-air warming, Intravenous fluid warming, Unwarmed intravenous fluids
- Where
- Russia
- Volunteers
- 61 people
- Sponsor
- The Leningrad Regional Clinical Hospital
Hyperglycemia
Sitagliptin in Non-Diabetic Patients Undergoing General Surgery
The purpose of this study is to compare sitagliptin with a placebo for the prevention of high glucose after general surgery.
- Trial name
- NCT02741687
- Testing
- Sitagliptin, Supplemental insulin (insulin lispro), Supplemental insulin (insulin aspart)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Neurodevelopmental Disorder, Bilateral Inguinal Hernia
Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
This is a prospective randomized controlled trial comparing dexmedetomidine sedation with caudal anaesthesia, and general sevoflurane anaesthesia with caudal anaesthesia for inguinal herniotomies in neonates and infants below 3…
- Trial name
- DEGA (NCT02559102)
- Testing
- Dexmedetomidine sedation, General sevoflurane anaesthesia, Caudal anaesthesia
- Where
- Singapore
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
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