Clinical trials: Global Surgery
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
Arrhythmia, Cardiac, Kidney Cancer
Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method
This study evaluates the incidence of cardiac arrhythmias during the perioperative period in patients undergoing open kidney cancer surgery in the lateral position.
- Conditions
- Arrhythmia, Cardiac, Kidney Cancer, Surgery, Anesthesia, Local
- Trial name
- NCT02988219
- Testing
- Bupivacaine-fentanyl, Holter ECG monitor, Open kidney cancer surgery
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Major Abdominal Surgery, General Anesthesia
Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation
In this study, the investigators propose to explore the hemodynamic variations induced by vasopressin and its influence on cardiac output, mean systemic pressure, and venous return resistance measured through cardiopulmonary…
- Conditions
- Major Abdominal Surgery, General Anesthesia, Mechanical Ventilation, Vasopressin Infusion
- Trial name
- CORVaso (NCT04935814)
- Testing
- Vasopressin, Arginine
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Breast Carcinoma, Breast Carcinoma in Situ
Postoperative Pain After Breast Surgery Under Tumescent Local Anaesthesia Versus General Anaesthesia ( TLA-001 )
The present study aims to investigate the impact of Tumescent Local Anesthesia (TLA) on pain perception following surgeries typical for breast cancer.
- Trial name
- NCT06335108
- Testing
- General Anaesthesia, Local tumescent anaesthesia
- Where
- Germany
- Volunteers
- 349 people
- Sponsor
- University Hospital Tuebingen
Cholelithiasis
Fundus-First Laparoscopic Cholecystectomy in Difficult Gallbladders: A Safe Alternative Technique
This retrospective cross-sectional study evaluated the safety and effectiveness of the fundus-first laparoscopic cholecystectomy (FFLC) technique in patients with difficult gallbladders.
- Trial name
- NCT07113704
- Testing
- Conventional Laparoscopic Cholecystectomy, Fundus-First Laparoscopic Cholecystectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- KANAN ISMAYILZADA, MD
Anesthesia, Preoxygenation
Preoxygenation Before General Anesthesia
Rationale of the study: we aim to clarify the question (related to still unclear and not univocal response) about the protective or unnecessary role of preoxygenation in non-critically ill patients (otherwise with no high risk of…
- Trial name
- PREOX2018 (NCT03802643)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Parma
Breast Cancer, Breast Surgery
Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia
This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia.
- Conditions
- Breast Cancer, Breast Surgery, Sentinel Lymph Node Biopsy, Methylene Blue
- Trial name
- NCT07040540
- Testing
- Methylene Blue, Standard Surgical Care Without Dye
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Elective Surgery, Coughing
Efficacy of Propofol vs Placebo in the Prevention of Coughing During Emergence of General Anesthesia Under Desflurane
Emergence of general anesthesia is a critical period, in the same way as the induction of anesthesia, during which several adverse events may occur.
- Trial name
- PROPOREV (NCT02932397)
- Testing
- Intravenous dose of 0.5 mg/kg of propofol, Intravenous dose of 0.05 mL/kg of saline solution
- Where
- Canada
- Volunteers
- 154 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pain, Postoperative, Anesthesia Complication
Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia
The use of opioid during surgery can cause side effects and may delay hospital discharge. Some studies have shown balanced sparing opioid anesthesia can optimize the side effects and and the time of discharge.
- Conditions
- Pain, Postoperative, Anesthesia Complication, Nausea, Vomiting
- Trial name
- GALOFF (NCT02953210)
- Testing
- dexter ketamine, Lidocaine Hydrochloride, Fentanyl Hydrochloride
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Lumbar Disc Herniation, Spinal Surgery
Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery
This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in…
- Conditions
- Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia
- Trial name
- PROPEEP (NCT07545733)
- Testing
- Mechanical Ventilation (PEEP)
- Volunteers
- 60 people
- Sponsor
- Harran University
Pain
A Prospective Study of Post-operative Opioid Use in General Surgery Patients
Patients undergoing approximately 10 common outpatient general surgical operations will be given a narcotic prescription for a specified number of pills.
- Trial name
- GSopioids (NCT02782884)
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cognitive Ability, General, Brain Injury
The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery
The incidence of postoperative cognitive dysfunction (POCD) is high and POCD affect the life quality and the prognosis of patients.
- Trial name
- NCT02123355
- Testing
- Induction of anesthesia, Intubation, Sevoflurane, remifentanil ,vecuronium
- Volunteers
- 80 people
- Sponsor
- Shaanxi Provincial People's Hospital
HoLEP, QoR-40
Effect of Anesthesia Techniques on Quality of Recovery Scores in HOLEP Surgery
The aim of this observational study is to evaluate the effects of different anesthesia techniques on the quality of recovery (QoR) and patient satisfaction in male patients, typically older adults with benign prostatic…
- Conditions
- HoLEP, QoR-40, Anesthesia, General, Anesthesia,Spinal
- Trial name
- NCT07020390
- Testing
- Anesthesia method
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- TC Erciyes University
Recovery Following Cholecystectomy
Multi-dose Acetaminophen for Patients Undergoing General Anesthesia
Study Objective The aim of the proposed study is to examine the effect of Q4 hour multidose IV acetaminophen on patients' readiness for discharge.
- Trial name
- NCT02832687
- Testing
- Acetaminophen, normal saline
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Rutgers, The State University of New Jersey
Postoperative Pain, Ambulatory Surgery
Comparison Between Pre-operative Prescription Delivered During Anesthesia Consultation or Post-operative Prescription
This study evaluates the comparison of the incidence of postoperative home pain after ambulatory surgery with general anesthesia between a group with pre-surgical prescription delivered during anesthesia preoperative clinic and a…
- Conditions
- Postoperative Pain, Ambulatory Surgery, Anesthesia, Postoperative Complication
- Trial name
- AMBUPRESS (NCT03205189)
- Testing
- Comparison between pre-operative prescription and post-operative prescription
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Emergency Abdominal Surgery, Mechanical Ventilation
Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery
The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at…
- Conditions
- Emergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity
- Trial name
- IMPROVE-2 (NCT03987789)
- Testing
- Driving-pressure-guided group, Low PEEP
- Where
- 28 sites in France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Clermont-Ferrand
Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery
The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General, Anesthesia, Spinal
- Trial name
- NCT06343259
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Gastroscopy
Chlorhexidine Mouthwash and Bacterial Contamination During Endoscopy
Background: Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has been rapidly evolving over the last five years.
- Trial name
- NCT01154530
- Testing
- Chlorhexidine
- Where
- Denmark
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
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