Clinical trials: Globus Pharyngeus
Huntington Disease
Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.
- Trial name
- NCT07513844
- Testing
- Low-Intensity Focused Ultrasound Stimulation（LIFU）
- Where
- China
- Volunteers
- 24 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Gastroesophageal Reflux Disease, Globus Pharyngeus
Manual Therapy Effects on Upper and Lower Esophageal Sphincter Pressures
The aim of this study is to test the influence of manual cervical traction and chest stabilization maneuvers on pressures in upper and lower esophageal sphincters.
- Trial name
- NCT03871426
- Testing
- manual therapy
- Where
- Czechia
- Volunteers
- 54 people
- Sponsor
- University Hospital, Motol
Tourette Syndrome
A Trial of Bilateral Deep Brain Stimulation to the Globus Pallidus Internum in Tourette Syndrome
The purpose of this study is to investigate whether deep brain stimulation (DBS) of the globus pallidus internum (GPi) can alleviate tics in Gilles de la Tourette syndrome (GTS) and whether this treatment has any influence on…
- Trial name
- NCT01647269
- Testing
- Bilateral GPi Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University College, London
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dysphagia, Gastroesophageal Reflux
Stimulation of Sensation and Improvement in Swallowing Using Oral Capsaicin
This is a research study to learn more about whether capsaicin, a natural ingredient of chili peppers that makes them taste "hot", can improve swallowing function.
- Trial name
- NCT01053286
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Globus Pharyngeus, Validation
The Validation of the Turkish Version of the LUMP Questionnaire
Purpose of the study is the validity and reliability of the Turkish version of the Laryngopharyngeal Measure of Perceived Sensation (T-LUMP) Questionnaire, so that it would be used as an assessment tool for Turkish globus…
- Trial name
- NCT04778007
- Testing
- Turkish Version of Laryngopharyngeal Measure of Perceived Sensation Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Tourette's Syndrome
High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome
Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia.
- Trial name
- NCT00139308
- Testing
- high frequency stimulation
- Where
- France
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Globus Pharyngeus
The Efficacy of Kinesio Taping With Therapy in the Treatment of Globus Pharyngeus
Globus pharyngeus or sensation may be defined as a feeling of something a lump in the throat without dysphagia. Kinesio tex tape is a medical tap developed by Dr.
- Trial name
- NCT04768205
- Testing
- Kinesio tape
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Huntington's Disease
Deep Brain Stimulation of the Globus Pallidus in Huntington's Disease
This is a single centre, controlled phase I study, which evaluates safety and efficacy of stimulation of lower caudal two contacts (GPI) vs. upper cranial two contacts (GPE) in Huntington´s disease (HD).
- Trial name
- NCT00902889
- Testing
- Stimulation
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Parkinson Disease
Feasibility of Remote Measures and Assessments in Deep Brain Stimulation for Parkinson's Disease (FoRMA-DBS)
This is an observational pilot study to assess the feasibility of remote functional assessments of gait, balance, and functional mobility via a telemedicine platform enabled via the Abbott Infinity devices.
- Trial name
- FoRMA-DBS (NCT05219019)
- Sponsor
- Boston Medical Center
Cervical Dystonia
Deep Brain Stimulation to Treat Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) for treating primary dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00132340
- Testing
- Electrodes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia, Schizoaffective Disorder
Dopamine D2 and D3 Receptor Occupancy and Clinical Response in Older Patients With Schizophrenia
This study will provide information regarding dopamine D2/D3 occupancy related with clinical/adverse effects in older people with schizophrenia and schizoaffective disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT00825045
- Testing
- risperidone
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Centre for Addiction and Mental Health
Somatoform Disorders, Globus Hystericus
Treatment of Globus Sensations With Psychotherapy
The purpose of this study is to determine whether psychotherapy (based on exposure techniques) is effective in the treatment of functional somatic symptoms (FSS)/Somatoform Disorders (as exemplified here in subjects with globus…
- Trial name
- NCT01590992
- Testing
- Exposure-based psychotherapy for somatic symptoms, Relaxation therapy
- Where
- Switzerland
- Volunteers
- 175 people
- Sponsor
- University Hospital, Basel, Switzerland
Compare the Response Rate of Atypical GERD After PPI Therapy
Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD
Patients with atypical gastro-esophageal reflux disease (GERD), include cough, globus, and non-cardiac chest pain (NCCP) usually require more aggressive or double dose proton pump inhibitor (PPI) therapy than patients with typical…
- Trial name
- NCT03418337
- Testing
- dexilansoprazole (Dexilant 60 mg), lansoprazole (Takepron OD 30 mg)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Parkinson Disease
Intrapatient Comparison of STN and GPi tTIS in PD
The goal of this clinical trial is to investigate the therapeutic efficacy of tTIS in patients with Parkinson's disease and to evaluate the immediate effects and conduct intrapatient comparisons of individualized 130 Hz…
- Trial name
- NCT07018388
- Testing
- NervioX-2400
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
Huntington Disease
Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD)
The aim of the study is to prove the efficacy and safety of pallidal DBS in HD patients and to show superiority of DBS on motor function in the stimulation group compared to stimulation-off group
- Trial name
- HD-DBS (NCT02535884)
- Testing
- ACTIVA® PC neurostimulator (Model 37601)
- Where
- 12 sites in Austria, France and 2 more
- Volunteers
- 48 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cervical Dystonia
Double-blind, Multicenter Study to Assess the Efficacy of Bilateral Pallidal Stimulation in Patients With Medically Refractory Primary Cervical Dystonia
The purpose of this study is to investigate the efficacy and safety of bilateral pallidal stimulation in patients with medically refractory primary cervical dystonia.
- Trial name
- NCT00148889
- Testing
- Deep brain stimulation (DBS)
- Where
- 10 sites in Austria, Germany
- Volunteers
- 63 people
- Sponsor
- German Parkinson Study Group (GPS)
Globus Pharyngeus
Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus
It is well known that 'globus sensation in throat' is caused by the chronic irritation and inflammation of oral, pharyngeal, or laryngeal mucosa, such as laryngopharyngeal reflux and chronic postnasal drip.
- Trial name
- NCT00381771
- Testing
- Conservative management for xerostomia
- Where
- South Korea
- Volunteers
- 340 people
- Sponsor
- Samsung Medical Center
Craniofacial Dystonia, Deep Brain Stimulation
Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: GPi or STN
MEIGES is a prospective, multicenter, randomized controlled clinical trial with the primary hypothesis that, STN-DBS is non-inferior to GPi-DBS for motor symptoms improvements at 365 days postoperatively in patients with…
- Trial name
- MEIGES (NCT05416905)
- Testing
- STN-DBS, GPi-DBS
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital
Laryngopharyngeal Reflux
Predictive Value of Subjective and Objective Measurement Tools for Extraesophageal Reflux
Acid reflux can cause many symptoms in the throat, including discomfort or pain, and difficulty with breathing and voice problems.
- Trial name
- NCT01829074
- Volunteers
- 150 people
- Sponsor
- Respiratory Technology Corporation