Clinical trials: Glucose Metabolism Disorders (Including Diabetes Mellitus)
Diabetes Mellitus
Pharmacokinetic and Pharmacodynamic Properties of BIOD-123 and BIOD-125 Compared to Humalog® in Subjects With Type 1 Diabetes Including Assessments of Injection Site Toleration
The primary objective is to assess the speed of absorption of BIOD-123 and BIOD-125 and compare them to Humalog.
- Trial name
- NCT01908894
- Testing
- BIOD-123, BIOD-125, Humalog
- Volunteers
- 12 people
- Sponsor
- Biodel
Glucose Metabolism Disorders (Including Diabetes Mellitus), Overweight and Obesity
Effect of Two Alcohol-free Beers With Different Carbohydrates Composition on Lipids and Glucose Metabolism
This a controlled, double-blind, randomized, cross designed study to determine the effect of an alcohol-free beer with low glycemic index carbohydrates (isomaltulose) and a resistant maltodextrin, comparing to an alcohol-free…
- Trial name
- NCT03337828
- Testing
- Alcohol-free beer with regular composition, Alcohol-free beer with modified composition
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Diabetes Mellitus
SNP Study of DPP-4 and GLP-1R in Chinese People (Including Diabetes Patients)
Incretin-based therapy is currently one of the most popular diabetes treatment approaches. However, differences of response ware found in previous studies.
- Trial name
- NCT03108521
- Testing
- Sitagliptin
- Where
- China
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Diabetes Mellitus Type 2 in Obese, Inflammation
IL-1-receptor Antagonist During Cephalic Phase of Insulin Secretion in Health and Type 2 Diabetes
A prospective, randomized, mixed double- and single-blinded, placebo-controlled, cross-over clinical trial to test whether acute treatment with an IL-1 receptor antagonist impacts insulin secretion over time during the cephalic…
- Conditions
- Diabetes Mellitus Type 2 in Obese, Inflammation, Metabolic Disease, Glucose Metabolism Disorders (Including Diabetes Mellitus)
- Trial name
- Cephalira (NCT04227769)
- Testing
- Anakinra Prefilled Syringe
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Type 1, Endothelial Dysfunction
Cardiovascular Risk Factors After Single Pancreas Transplantation
Patients accepted for the waiting list for single pancreas transplantation suffer from severe glucose instability with hyperglycemia due to diabetes type 1, but do not have significant diabetes-related complications.
- Trial name
- Diamant (NCT02066350)
- Testing
- Single pancreas transplantation
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Glucose Metabolism Disorders (Including Diabetes Mellitus)
Continuous Glucose Monitoring in Patients Undergoing Cardiopulmonary Bypass
The purpose of this research study is to test the accuracy of the Dexcom continuous glucose monitoring device during the cardiothoracic surgical procedure and recovery period in the Cardiac Intensive Care Unit.
- Trial name
- NCT06861881
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes
Capability Assessment for Diet and Activity (CADA) Model for Diabetes
This study investigates the capabilities related to diet, physical activity, screening, and knowledge among diabetic adults with or without a history of hospital admissions in Central Florida.
- Trial name
- NCT06631105
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Central Florida
Type 2 Diabetes Mellitus (T2D)
Culturally Tailored Program for Food-Insecure Adults: SPICE-D
The goal of this pilot intervention study is to learn if culturally appropriate food bundles and nutrition education can help people with diabetes who struggle to afford healthy food in patients with diabetes receiving care at…
- Trial name
- SPICE-D (NCT07361341)
- Testing
- Food Bundle Intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes Mellitus, Type 1
Research Study in Japan to Compare Dasiglucagon With Glucagon in Treating Very Low Levels of Blood Sugar in Asian Adults With Type 1 Diabetes and Testing of Dasiglucagon for the Same Condition in Japanese Adolescents
This study will be looking to confirm the effect of dasiglucagon when compared with glucagon for treating very low sugar levels in Asian adults with T1D and the effect of dasiglucagon in Japanese adolescents with T1D.
- Trial name
- NCT06588504
- Testing
- Dasiglucagon, Glucagon
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Foot Ulcers
Evaluation of Negative Pressure Wound Therapy in the Treatment of DFUs Incl. Post Amputation Wounds.
Primary objective To assess wound healing and granulation tissue formation when using the NPWT system Secondary objectives To investigate the pain level at dressing removal To visually check exudate removal To investigate the…
- Trial name
- NCT01011387
- Testing
- NPWT System
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Molnlycke Health Care AB
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study Called FIRST-2.0 to Learn More About the Use of the Study Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
This is an observational study, in which data from people in the United States (US) with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied.
- Trial name
- FIRST-2 (NCT05703880)
- Testing
- Finerenone (Kerendia, BAY948862)
- Where
- 2 sites in United States
- Volunteers
- 15,948 people
- Sponsor
- Bayer
Type 2 Diabetes Mellitus
Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)
This study evaluated the safety and efficacy of ertugliflozin (MK-8835) in pediatric participants with T2DM on metformin with/without insulin.
- Trial name
- NCT04029480
- Testing
- Ertugliflozin 5 mg, Ertugliflozin 15 mg, Insulin
- Where
- 104 sites in United States, Belgium and 20 more
- Volunteers
- 166 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes, PreDiabetes
Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial
The proposed randomized controlled trial will test the effect of a low-carbohydrate diet on hemoglobin A1c among individuals with elevated hemoglobin A1c that are within the range of prediabetes or diabetes.
- Conditions
- Diabetes, PreDiabetes, Metabolic Disease, Hyperglycemia
- Trial name
- ADEPT (NCT03675360)
- Testing
- Low-Carbohydrate Diet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Public Health and Tropical Medicine
Type2 Diabetes, Diabetes Mellitus, Type 2
Integration of Health Coaching and Diabetes Education in Type 2 Diabetes Mellitus Management at Primary Health Care
Type 2 Diabetes Mellitus is a chronic disease with increasing incidence globally. It needs a comprehensive and continuous management approach that includes five pillars: education, nutritional management, physical activity…
- Conditions
- Type2 Diabetes, Diabetes Mellitus, Type 2, Endocrine System Diseases, Nutritional and Metabolic Diseases
- Trial name
- NCT05090488
- Testing
- Personal Health Coaching and Diabetes Education in Group
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Universitas Indonesia
Diabetes Mellitus, Type 2
Oral and Non-insulin Injected Hypoglycemic Therapy Utilization Patterns
This protocol is for a series of descriptive analyses conducted within a cohort of patients using linagliptin, other dipeptidyl peptidase-4 (DPP-4) inhibitors, and other oral and non-insulin injected hypoglycemic medications…
- Trial name
- NCT02138097
- Where
- United States
- Volunteers
- 615,067 people
- Sponsor
- Boehringer Ingelheim
Glucose Metabolism Disorders (Including Diabetes Mellitus), Metabolic Disease
Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM
This randomized controlled trial (RCT) with 250 patients suffering from type 2 diabetes mellitus (T2DM) aims to investigate the effectiveness of the self-guided digital therapeutic covivio.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Metabolic Disease, Endocrine System Diseases, Diabetes Mellitus, Type 2
- Trial name
- EASE-T2DM (NCT06529965)
- Testing
- covivio
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Gaia AG
Type 2 Diabetes Mellitus
Observational Study of Triple Combination Therapy of Zemidapa Tab. and Metformin in Type 2 Diabetes Mellitus Patients
The aim of this study is to evaluate the effectiveness and safety of the triple combination therapy of Zemidapa Tab. and Metformin in patients with type 2 diabete mellitus
- Trial name
- NCT06495281
- Where
- South Korea
- Volunteers
- 2,044 people
- Sponsor
- LG Chem
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study Called FIRST-2.0 China to Learn More About the Use of the Study Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions in a Chinese Population.
This is a post-authorization safety study (PASS) to describe the real-world use of finerenone in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2D) in China.
- Trial name
- FIRST-2_CN (NCT07124039)
- Testing
- Finerenone (Kerendia, BAY948862)
- Where
- China
- Volunteers
- 6,537 people
- Sponsor
- Bayer
Diabetes Mellitus, Glucose Intolerance
Prevalence of Glucose Intolerance and Risk Factors in Ethiopian Immigrants in Israel; Follow-up Study.
High risk population: Screening for impaired glucose tolerance.
- Trial name
- NCT01402362
- Where
- Israel
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Obesity, Prehypertension
Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight…
- Conditions
- Obesity, Prehypertension, Hypertension, PreDiabetes
- Trial name
- WISE Health (NCT06284681)
- Testing
- Weight-focused health coaching, Weight-neutral health coaching, Intensify lifestyle approach
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Alabama at Birmingham