Clinical trials: Glucose Tolerance
Dyslipidemia, Impaired Glucose Tolerance
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose
The investigators evaluated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in Caribbean…
- Trial name
- NCT02938091
- Testing
- High-fat diet, Low-fat diet
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tufts University
Hyperlipidemia, Ursodeoxycholic Acid
Ursodeoxycholic Acid Attenuates Statin-Induced Impaired Glucose Tolerance
The purpose of this clinical trial is to understand whether the drug Ursodeoxycholic acid (UDCA) can prevent glucose intolerance in participants with hyperlipidemia who are taking statins. It will also assess the safety of UDCA.
- Conditions
- Hyperlipidemia, Ursodeoxycholic Acid, Statin Therapy, Glucose Intolerance
- Trial name
- URSTAR (NCT06684106)
- Testing
- Ursodeoxycholic acid (UDCA) 500 mg
- Where
- 2 sites in China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Type1 Diabetes
The Role of the Thymus in Type I Diabetes.
Regulatory T lymphocytes play a major role in the protection from autoimmune pathology. Defects in immunosuppression mediated by these cells is therefore suspected to contribute to these diseases.
- Trial name
- TregDiab (NCT03236558)
- Testing
- Blood collection
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
PCOS
Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin…
- Trial name
- NCT06155708
- Testing
- Ketone, Water
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University
Impaired Glucose Tolerance, Prediabetes
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical.
- Trial name
- NCT05387551
- Testing
- CGM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
Obesity, Type 2 Diabetes
The Effects of Weight Loss on Neuroadrenergic Function
Elevated subconscious nervous system activity is a characteristic of the obese state and contributes importantly to the risk of heart disease and diabetes.
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01771042
- Testing
- Dietary weight loss at 25% energy deficit
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Baker Heart Research Institute
Type 2 Diabetes
Preprandial Ghrelin Effect
Background and Significance: The peptide hormone ghrelin drives hunger and feeding behavior, making it a focus of obesity research.
- Trial name
- NCT02913703
- Testing
- Ghrelin, Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jenny Tong, MD, MPH
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Resistance Training for the Improvement of Glycemic Control in Prediabetes
The purpose of this research is to study the effects of resistance exercise training with different degrees of effort on your glucose responses (what we call glycemic control) and psychological responses.
- Trial name
- NCT06697756
- Testing
- High-effort resistance exercise training, Low-effort resistance exercise training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of New Mexico
Body Composition, Visceral Obesity
Dysfunctional Adiposity and Glucose Impairment
This is a large and comprehensively phenotyped cohort with fasting glycaemia where the predictive value of body composition and anthropometric measures of total and central fat distribution for postprandial carbohydrate…
- Conditions
- Body Composition, Visceral Obesity, Carbohydrate Intolerance, Obesity, Abdominal
- Trial name
- DICAMANO (NCT03506581)
- Volunteers
- 853 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Oral Glucose Tolerance
Coffee Roasting and Glucose Tolerance
Chlorogenic acid (CGA) in coffee may lower the postprandial glucose response. CGA is destroyed by dark roasting. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light (LIR) or dark (DAR)…
- Trial name
- NCT02417519
- Testing
- DAR, LIR, CTR
- Where
- Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Postprandial Hyperglycemia
Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance
Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being.
- Trial name
- NCT03159065
- Testing
- Bilberry, Blackcurrant, Mango
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lund University
Impaired Glucose Tolerance, Diabetes
Progression to Impaired Glucose Tolerance and Type 2 Diabetes in the Korean People-based KNDP Study
Impaired glucose tolerance is a metabolic state between normal glucose homeostasis and diabetes. Previously, prospective studies have shown higher progression rates from IGT to diabetes in other country.
- Trial name
- NCT01034826
- Volunteers
- 500 people
- Sponsor
- Korea University Guro Hospital
Type 2 Diabetes, Glucose Tolerance Impaired
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM
With REMD's glucagon receptor antagonist, the study team propose to provide a comprehensive examination of the effect of elevated plasma glucagon concentrations in Type 2 Diabetes Mellitus (T2D) patients on: (i) glucose…
- Conditions
- Type 2 Diabetes, Glucose Tolerance Impaired, Insulin Sensitivity
- Trial name
- NCT05093517
- Testing
- REMD-477
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Prediabetes
Effects of Autonomic Nervous System Modulation by Heart Rate Variability Biofeedback Training With Resonant Frequency Breathing on Glucose Metabolism in Individuals With Prediabetes
Approximately 20% of adults have prediabetes in Germany. Prediabetes is defined as a condition with glucose levels outside the normal range but not yet meeting the criteria for type 2 diabetes.
- Trial name
- RwHRVBFinPD (NCT06739993)
- Testing
- Resonance frequency breathing with heart rate variability biofeedback training, Anti-Stress program
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Johannes Gutenberg University Mainz
Diabetes, Hyperglycemia
Insulin Secretion in Diabetes Before and After Glycemic Control
The objective of this project is to understand defects in insulin secretion that contribute to abnormal glucose metabolism in patients with diabetes.
- Trial name
- NCT00469833
- Testing
- insulin glargine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Ketogenic Dieting, Epilepsy
Evaluation of Krio in Children and Adults With Epilepsy
Acceptability study to evaluate the gastrointestinal tolerance, palatability and participant compliance, over a 7-day period, of Krio for the dietary management of participants with intractable epilepsy or Glut-1 deficiency…
- Conditions
- Ketogenic Dieting, Epilepsy, Glucose Transporter Type 1 Deficiency Syndrome
- Trial name
- Krio (NCT03202108)
- Testing
- Krio
- Sponsor
- Vitaflo International, Ltd
Hypertension, Type 2 Diabetes Mellitus
Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance
Various guidelines recommended angiotensin converting enzyme (ACE) inhibitors or angiotensin Ⅱ receptor-1 blockers (ARBs) for hypertensive patients with diabetes on the basis of the cardiac- and reno-protective effects of these…
- Trial name
- NCT00129233
- Testing
- Valsartan, Amlodipine
- Where
- Japan
- Volunteers
- 1,150 people
- Sponsor
- Nagoya University
Coronary Heart Disease, Diabetes Mellitus
A Survey to Evaluate the Rate of Abnormal Glucose Tolerance Among Hong Kong Chinese Subjects With Coronary Heart Disease
Hypothesis: there is a high prevalence rate of diabetes, including asymptomatic undiagnosed glucose intolerance, among subjects with coronary heart disease in Hong Kong.
- Trial name
- NCT00786175
- Where
- China
- Sponsor
- Chinese University of Hong Kong
Impaired Glucose Tolerance
Effect of Saxagliptin Treatment on Myocardial Fat Content, and Monocyte Inflammation
The purpose of the study is to examine the effect of saxagliptin, an anti-diabetes medication, on hepatic and myocardial fat content and monocyte inflammation in patients with Impaired Glucose Tolerance (IGT).
- Trial name
- NCT01548651
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine