Clinical trials: Glucose Tolerance
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT)
The goal of this clinical trial is to prevent the change from prediabetes (a pre-stage of type 2 diabetes mellitus (T2DM)) to T2DM in participants with prediabetes using oral CIR-NA (a nicotinic acid formulation that is designed…
- Trial name
- CONCEPT (NCT07286747)
- Testing
- controlled-ileal-release nicotinic acid as multiple dose 100 mg/day, controlled-ileal-release nicotinic acid as multiple dose 200 mg/day
- Where
- 6 sites in Germany
- Volunteers
- 390 people
- Sponsor
- University Hospital Schleswig-Holstein
PreDiabetes
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1.
- Trial name
- NCT06967558
- Testing
- Exendin 9-39, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Determining the Glycemic Effects of Three Types of Spaghetti
This study investigated the effects of thee types of spaghetti No7 on the glycemic response
- Trial name
- NCT05197283
- Testing
- Glucose as reference food, White bread, Regular spaghetti
- Where
- Greece
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Liver Fat, Type 2 Diabetes
EXIT: Prospective Study of the Response to Exercise
Background : Regular exercise is a cornerstone in the prevention and the management of comorbidities. Unfortunately, the metabolic benefit of exercise training is not universal and varies among individuals.
- Trial name
- EXIT (NCT02204670)
- Testing
- Acute release of irisin after a single exercise session.
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Multiple Sclerosis
Impaired Glucose Tolerance and Cognition in MS
This is a pilot study to compare cognitive performance in two groups of subjects with multiple sclerosis; those with normal glucose tolerance and those with impaired glucose tolerance.
- Trial name
- NCT04748302
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia
Hypertension, Impaired Glucose Tolerance
Telmisartan and Losartan in Hypertensive IGT
Inhibition of RAS delays onset of diabetes in clinical studies. Preliminary evidence suggests that telmisartan may have unique metabolic properties compared to other ARB due to activation of PPARγ.
- Trial name
- NCT00407862
- Testing
- Telmisartan 80 mg, Losartan 50 mg
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Resistance Training for the Improvement of Glycemic Control in Prediabetes
The purpose of this research is to study the effects of resistance exercise training with different degrees of effort on your glucose responses (what we call glycemic control) and psychological responses.
- Trial name
- NCT06697756
- Testing
- High-effort resistance exercise training, Low-effort resistance exercise training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of New Mexico
Impaired Glucose Tolerance
Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)
The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
- Trial name
- NCT01219231
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 1
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Type 1 diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the…
- Trial name
- TN07 (NCT00419562)
- Testing
- Oral Insulin
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 560 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Impaired Glucose Tolerance, Diabetes
The Effects of Exercise on Adipokine in Impaired Fasting Glucose or Impaired Glucose Tolerance Patients
Many adipokines are thought that related with metabolic disturbance such as glucose intolerance, dyslipidemia, and insulin resistance.
- Trial name
- NCT00472342
- Testing
- exercise prescription
- Where
- South Korea
- Volunteers
- 182 people
- Sponsor
- Yonsei University
Type 2 Diabetes
The Importance of GLP-1 in Post RYGB Improvement in Glycaemic Control Type 2 Diabetic Subjects
After Roux-en-Y gastric bypass (RYGB) meal induced GLP-1 secretion is dramatically increased, while beta-cell function is increased in type 2 diabetic (T2D) subjects.
- Trial name
- NCT01579981
- Testing
- Roux-en-Y Gastric Bypass
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Hvidovre University Hospital
Exercise, Heat Strain
Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults
Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy.
- Conditions
- Exercise, Heat Strain, Control Condition
- Trial name
- NCT06872762
- Testing
- Exercise, Heat strain
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Glucose Tolerance
Peripheral Heating and Glucose Tolerance
Effect of peripheral heating on glucose tolerance
- Trial name
- NCT05300256
- Testing
- Peripheral Heating
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Periodontitis, Prediabetes
Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects
This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.
- Trial name
- PARODIA2 (NCT02830113)
- Testing
- non-surgical periodontal treatment
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yaounde Central Hospital
Overweight
Effects of Caffeinated and Decaffeinated Coffee on Body Weight and Glucose Tolerance
Habitual consumption of coffee may have substantial beneficial effects on glucose metabolism according to recent findings of epidemiological studies in the U.S., Europe, and Japan.
- Trial name
- NCT00305097
- Testing
- Decaffeinated coffee, Caffeinated coffee, No coffee
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Subjects, Diet Intervention
Effects of Plant-based Polar Lipids on Acute and Second Meal Glucose Tolerance and Appetite Sensations
The overall goal of the project is to increase knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people.
- Trial name
- NCT05844085
- Testing
- Non-polar lipids, No lipids, Polar lipids low
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Impaired Glucose Tolerance
Prevention of Type 2 Diabetes in Children With a Family-based Healthy Lifestyle Program
The purpose of this study is to determine if the Bright Bodies (BB) Healthy Lifestyle Program can help reverse early abnormalities in glucose metabolism and prevent the progression to type 2 diabetes (T2DM) in high-risk, obese…
- Trial name
- NCT01030978
- Testing
- Bright Bodies Healthy Lifestyle Program, Control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
Insulin Tolerance, Hormone
Effect of Ingestion of Human, Cow, and Modified-cow Milk, on Glucose and Hormone Responses in Humans.
Human milk, despite a much lower protein content, is as effective as cow milk on insulin stimulation under iso-lactose conditions. The causes for such a similar potency are unknown.
- Conditions
- Insulin Tolerance, Hormone, Aminoacidaemia
- Trial name
- PROLAT (NCT04698889)
- Testing
- natural cow, high protein cow milk, natural human
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Padova
Impaired Glucose Tolerance
Breaks in Sedentary Time and Glucose Regulation in Women
The number of people diagnosed with Type 2 diabetes (T2DM) is increasing rapidly and about 2.9 million people in the UK currently have diabetes.
- Trial name
- ACUTE (NCT02135172)
- Testing
- Sitting, Standing, Walking
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Leicester
Healthy
Single Dose Study Of PF-04308515 And Prednisone On Carbohydrate
This study will investigate the effect of a single dose of PF-04308515 or prednisone on calculated measures of glucose tolerance and insulin resistance by using a modified oral glucose tolerance test.
- Trial name
- NCT01199029
- Testing
- PF-04308515, Prednisone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer