Clinical trials: GnRH Antagonist
Ovarian Hyperstimulation Syndrome
The Use of GnRH Agonist Trigger in the Prevention of OHSS
To compare the incidence of ovarian hyperstimulation syndrome (OHSS) and implantation rate between high responder patients using Gonadotropin releasing GnRH) agonist or human chorionic gonadotropin (hCG) to trigger final oocyte…
- Trial name
- NCT00349258
- Testing
- Leuprolide acetate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Genomic Human Endometrial Expression Profile
Endometrial Genomic Profile in Endometrial Priming
The aim of this study is to analyse genomics profile expression in endometrium under different endometrial priming for recipients.
- Trial name
- NCT01778452
- Testing
- endometrial biopsy
- Where
- Spain
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
GnRH Antagonist IVF Protocol, Fresh Embryo Transfer
GnRH for Luteal Support - Mechanism of Action
This prospective observational study will include women undergoing IVF treatment with a GnRH antagonist protocol and fresh embryo transfer at the IVF unit of Shaare Zedek Medical Center.
- Conditions
- GnRH Antagonist IVF Protocol, Fresh Embryo Transfer, Administration of Hormonal Luteal Support
- Trial name
- NCT07620067
- Testing
- GnRH agonist, Progesterone
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Heli Alexandroni
Contraception
Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (HOP 5) Testicular Aspiration Addendum
This study is being offered to all participants of the ACY-5 study as an optional addition to the male contraceptive study in which they participated. Participation is voluntary.
- Trial name
- IHOP-5 (NCT00156650)
- Testing
- Acyline, Testosterone Gel, Depo-Medroxyprogesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infertility
Predictive Factors for Ovarian Stimulation Using a Fixed Daily Dose of 200 IU Recombinant FSH (Study 142003)(P05696)
The success of assisted reproductive technologies (ART) is critically dependent on optimizing protocols for controlled ovarian stimulation to provide adequate numbers of good quality oocytes and embryos.
- Trial name
- Xpect (NCT00778999)
- Testing
- Marvelon
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Uterine Fibroid
The Impact of a Novel GnRH Antagonist With Add-back Therapy for Treatment of Uterine Fibroids and Endometriosis on Hemostasis Parameters
Uterine fibroids and endometriosis are two frequent diseases among women of reproductive age. They can be responsible for chronic and/or menstrual pelvic pain and abnormal uterine bleeding.
- Trial name
- NCT07173127
- Testing
- Ryeqo treatment
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Polycystic Ovary Syndrome
Repeated Doses of GnRH Agonist as Oocyte Triggering in Antagonist Protocol for Patients With Polycystic Ovary Syndrome
This is a prospective, randomized, proof-of-concept study, designed to compare the IVF results in patients diagnosed with polycystic ovarian syndrome (PCOS) defined as per the ESHRE/ASRM Rotterdam criteria (2003) undergoing…
- Trial name
- NCT04600986
- Testing
- Repeated dose of GnRH agonist
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Healthy Volunteers
Letrozole Treatment in Normal and GnRH Deficient Women
This research study involves the use of the drugs Letrozole, GnRH, and NAL-GLU GnRH antagonist. Letrozole is a drug that is approved by the U.S.
- Trial name
- NCT00351416
- Testing
- Letrozole, NAL-GLU GnRH antagonist
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Cetrotide Treatment Optimization
Rationale: In daily practice fertility treatment is increasingly patient focused and innovative medication and standardized treatment guidelines are being developed to improve patient convenience.
- Trial name
- NCT00866034
- Testing
- Cetrotide (Ovarian stimulation)
- Where
- Netherlands
- Volunteers
- 617 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Infertility
GnRH Agonist and Progesterone Versus Progesterone Only for Luteal Phase Support in Antagonist Cycles
In-Vitro Fertilisation (IVF) is the term commonly applied to a form of treatment for infertility that involves controlled ovarian hyperstimulation, egg maturation, egg collection, fertilisation, embryo culture and finally embryo…
- Trial name
- GALA (NCT02262416)
- Testing
- leuprolide
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queensland Fertility Group
Infertility, Female
A New Revolutionary 3-Injection- Protocol in Infertile Women
This is a prospective randomised study of the evaluation of the clinical IVF results after following a new revolutionary 3-Injection- Protocol for controlled ovarian stimulation in infertile women.
- Trial name
- NCT03877185
- Testing
- Live birth rate
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Infertility, Premature Ovarian Failure
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.
A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in…
- Trial name
- NCT03861715
- Testing
- live birth rate
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Infertility
The Effect of GnRH Agonist Administered in the Luteal Phase on ART Cycle Outcomes
This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol.
- Trial name
- NCT02114645
- Testing
- Leuprolide acetate, vaginal progesterone, 4 mg oral estradiol valerate
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
In Vitro Fertilization
Comparing Coasting by Withholding GnRH Agonist With GnRH Antagonist
Ovarian hyperstimulation syndrome (OHSS) is the most serious complication of ovulation induction and is a life threatening iatrogenic complication.
- Trial name
- NCT01347268
- Testing
- GnRH antagonist, withdrawing GnRH agonists
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
hCG
Earlier Triggering in Rec-FSH/GnRH Antagonist Cycles
The effect of altering the timing of hCG administration on the ongoing pregnancy rate in patients stimulated with recombinant-FSH (rec-FSH)/gonadotrophin releasing hormone (GnRH) antagonists for in vitro fertilisation (IVF).
- Trial name
- 16mm (NCT01390207)
- Testing
- 16mm triggering
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Healthy
ACY-7 Oral Administration of Acyline
We propose oral dosing of gastrointestinal permeation enhancement technology [GIPET] enhanced oral acyline at 20 mg everyday for one week to determine the steady-state (multiple-dose) pharmacokinetics of oral acyline in four…
- Trial name
- ACY-7 (NCT00603187)
- Testing
- Acyline
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Washington
Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin
GnRH Antagonist for Treatment of Early Ovarian Hyperstimulation Syndrome
The aim of this study is to analyze the effectiveness of GnRh antagonist in the treatment of early ovarian hyperstimulation syndrome.
- Conditions
- Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin, Oocyte Maturation
- Trial name
- NCT01268761
- Testing
- GnRH antagonist (Cetrorelix)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Female Infertility
There is a Value of Luteinizing Hormone Predictive of in Vitro Fertilization Treatment Outcome in Antagonist Protocols?
This study, prospective randomized controlled trial, tried to identify a cut off value of luteinizing hormone predictive of in vitro fertilization outcome in a fixed or flexible gonadotropin-releasing hormone antagonist…
- Trial name
- NCT02328924
- Testing
- LH value
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- U.O.S. Procreazione Medicalmente Assistita e Congelamento Gameti
PCOS GnRH Antagonist and GnRH Agonist IVF/ICSI Cycles
In Vitro Fertilization Outcomes of Two Treatment Protocols in Women With Polycystic Ovary Syndrome
Outcomes of IVF/ICSI cycles of women with PCOS undergoing Gonadotropin Releasing Hormone (GnRH) agonist and GnRH Antagonist fixed protocol.
- Trial name
- PCOS and ivf (NCT01354275)
- Testing
- To compare the IVF/ICSI outcomes of GnRH Antagonist cycle versus GnRH agonist cycle, GnRH Antagonist
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bulent Haydardedeoglu
Ovarian Stimulation
Luteinizing Hormone (LH) Supplementation in Gonadotropin-releasing Hormone (GnRH) Antagonist Cycles
To analyse the impact on cycle outcome of LH supplementation in ovarian stimulation controlled with a GnRH antagonist in two ages groups: patients upto 35 years old, and patients aged between 36 and 39 years old.
- Trial name
- NCT01037699
- Testing
- rFSH: Follicle Stimulating Hormone, rFSH: Follicle Stimulating Hormone and rLH: Luteinizing Hormone (Recombinant Luteotrophin alfa)
- Where
- Spain
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA