Clinical trials: GnRH Antagonist
Infertility
Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation
The purpose of this study is to compare the efficacy of two controlled ovarian stimulation protocols, the GnRH agonist protocol, widely known as the "long" protocol, and the flexible GnRH antagonist protocol, in terms of…
- Trial name
- NCT00417183
- Testing
- Arvekap 0.1 mg (Triptorelin, Ipsen, France), Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Eugonia
Stimulation in the Ovary, IVF Outcome
Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol
There are several approaches to the timing of antagonist administration in IVF/ICSI cycles. The primary goal is indeed to prevent premature ovulation, which could jeopardize the success of the cycle There is an emerging concept…
- Trial name
- NCT06879002
- Testing
- Ovarian stimulation with menstruation or after ovulation
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol
The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.
- Trial name
- NCT01419353
- Testing
- estradiol valerate
- Where
- Israel
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome
This study is a randomized controlled clinical trial to compare the pregnancy outcomes of mild and minimal stimulation in infertile women with polycystic ovarian syndrome.
- Trial name
- NCT03876145
- Testing
- Minimal ovarian stimulation
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Folliculogenesis
An Open-label Study of the Effects of Elagolix in Adult Premenopausal Females
This is an open-label Phase 1 study in healthy premenopausal females evaluating the effects of different dosing regimens of elagolix on ovarian activity, ovulation, and ovarian reserve and to assess the effect of elagolix on…
- Trial name
- NCT01403038
- Testing
- Elagolix
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- AbbVie (prior sponsor, Abbott)
Infertility, Female
Exploratory Study Assessing Synchronisation of Egg Sacs With Degarelix
The main purpose of this clinical research study is to investigate if degarelix can synchronise the growth of the egg sacs in the ovaries and if degarelix has any effect on the lining of the womb.
- Trial name
- NCT00434122
- Testing
- Degarelix mid-luteal, 2.5 mg
- Where
- 4 sites in Belgium, Czechia and 1 more
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Ovarian Hyperstimulation Syndrome
Luteal Antagonist Versus Conventional Treatment in Women With Severe Early Ovarian Hyperstimulation Syndrome (OHSS)
The study aims to compare the novel method of GnRH antagonist administration in the luteal phase versus conventional treatment in IVF patients who develop severe early ovarian hyperstimulation syndrome and have all their embryos…
- Trial name
- NCT02392520
- Testing
- cetrorelix (cetrotide)
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eugonia
Fertility
Effect of GnRH Antagonist vs Agonist Long on IVF Outcome, Peak Estradiol Level,and Duration of Stimulation
The purpose of this study is to determine if utilizing GnRH antagonists versus agonist long protocol during controlled ovarian stimulation (COH) with human-derived gonadotropins for assisted reproduction affects IVF outcome, peak…
- Trial name
- NCT01669291
- Testing
- Bravelle and Menopur, Agonist, Antagonist
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Infertility, Premature Ovarian Failure
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
The purpose of this study is to compare ovulation induction using a flexible GnRH antagonist protocol and flare up GnRH agonist protocol in IVF patients with poor response to ovarian stimulation.
- Trial name
- NCT00417066
- Testing
- Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands), Arvekap 0.1mg (Triptorelin, Ipsen, France)
- Where
- Greece
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Eugonia
Female Infertility Due to Nonimplantation of Ovum, Complications Associated With Artificial Fertilization
Comparing Ovarian Stimulation for Assisted Reproduction With Two Different Forms of Pituitary Suppression
The purpose of this study is to assess the non-inferiority of a multidose GnRH antagonist (cetrorelix) regimen to a GnRH agonist (triptorelin) long protocol in young infertile women undergoing ovarian stimulation with Pergoveris…
- Trial name
- Pergoveris (NCT01565265)
- Testing
- Pergoveris in long protocol with GnRH agonist, Pergoveris in GnRH antagonist protocol
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Fertility
An Exploratory Study to Investigate the Effect of FE 999302 When Given Together With Follitropin Delta During Controlled Ovarian Stimulation
This is a phase 1b clinical trial with Choriogonadotropin beta (FE999302) and Follitropin delta (Rekovelle). The trial is multicentre, randomized, partially double-blind, placebo-controlled, parallel-group investigating the…
- Trial name
- Celestial-1 (NCT06466486)
- Testing
- Follitropin delta, FE999302
- Where
- 15 sites in Belgium, Czechia and 3 more
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility
Randomized Controlled Trial Comparing Embryonic Quality in rFSH Versus hMG in IVF Protocol With GnRH Antagonist
rFSH and HMG are both used to controlled ovarian stimulation for patients submitted to IVF. However, there is a debate in the literature which one is better to induce ovulation in patients receiving GnRH antagonist to block…
- Trial name
- NCT02412904
- Testing
- rFSH, HMG
- Where
- Brazil
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University