Clinical trials: Goal Directed Therapy
Postoperative Complications
Effects of Intraoperative Goal-Directed Fluid Therapy on the Incidence of Postoperative Complications
Excessive fluid loss is often reported in gastrointestinal surgical patients due to preoperative fasting and bowel preparations.
- Trial name
- NCT02507557
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Surgical Procedures, Operative
Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Abdominal Surgery
This study evaluates whether using information from a special arterial blood pressure monitor to guide how much fluid is given during surgery changes how long a patient stays in the hospital after the surgery.
- Trial name
- NCT01082614
- Testing
- Vigileo
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Loma Linda University
Fluid Loss, Enhanced Recovery
Role of Goal Directed Fluid Therapy in Enhanced Recovery After Surgery in Gastro-intestinal Oncosurgeries
Enhanced recovery after surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery and reducing postoperative morbidity after surgical procedures by maintaining preoperative organ…
- Trial name
- GDFT ERAS (NCT06026475)
- Testing
- Goal directed Fluid Therapy, Conventional Fluid Therapy
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Heart; Dysfunction Postoperative, Cardiac Surgery, C.Surgical Procedure; Cardiac
Goal Directed Therapy Aiming to Optimise Oxygen Central Venous Saturation in Children Undergoing Cardiac Surgery
The purpose of this study is evaluate goal-directed therapy with continuous central venous saturation compared to standard therapy in children undergoing cardiac surgery.
- Trial name
- NCT03469440
- Testing
- Continuous central venous oxygenation monitoring, Standard protocol
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Instituto do Coracao
Lung Ultrasound, Goal Directed Therapy
Lung Ultrasound-guided Hemodynamic Optimization
The formalized expert recommendation of the French Society of Anesthesia and Intensive Care recommends guiding vascular filling by measuring the stroke volume (SV) in surgical patients considered at high risk.
- Conditions
- Lung Ultrasound, Goal Directed Therapy, Non-cardiac Surgery
- Trial name
- POINTBAR (NCT05481723)
- Testing
- noradrenaline and vascular filling, pulmonary ultrasound after vascular filling
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Surgery, Perioperative Complication
BRAIN-targeted Goal-directed Therapy in High-risk Patients undeRgOing Major electIve SurgEry: the BRAIN-PROMISE Study
The aim of the study is to further understand whether the use of non-invasive monitoring NIRS (Near Infrared Spectroscopy) is useful in reducing postoperative complications in high-risk patients undergoing elective surgery.
- Trial name
- BRAINPROMISE (NCT04266574)
- Testing
- Near Infrared Spectroscopy (NIRS), Standard Care
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Esophagus Cancer
Goal-directed Enteral Nutritional Perioperative Management
This clinical trial aims to determine whether perioperative goal-directed nutritional therapy can prevent postoperative pulmonary and other major complications in malnourished esophageal squamous cell cancer patients.
- Trial name
- GENTLEMAN (NCT06510543)
- Testing
- Goal-directed EN therapy, Conventional EN therapy
- Where
- 17 sites in China
- Volunteers
- 400 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Urinary Bladder Neoplasms, Cystectomy
Radical Cystectomy, Nutrition and Convalescence
The purpose of this study is to determine whether a goal directed nutritional intervention can reduce the convalescence period for patients undergoing radical cystectomy (RC).
- Conditions
- Urinary Bladder Neoplasms, Cystectomy, Bladder Cancer
- Trial name
- NCT02238886
- Testing
- Parenteral nutrition. SMOFKABIVEN infusion in central vene. Fresenius Kabi
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intraoperative Hypotension
The Predict H Trial
The aim of the study is to determine whether a goal-directed algorithm based on the prevention of arterial hypotension using the Hypotension Prediction Index reduces the duration and severity of intraoperative hypotension when…
- Trial name
- NCT04301102
- Testing
- Hemosphere platform® together with the FloTrac Acumen IQ® sensor, Hemosphere platform® together with the FloTrac® sensor
- Where
- 5 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Juan Victor Lorente
Coronary Artery Disease, Hemodynamic Monitoring
Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery
The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen…
- Conditions
- Coronary Artery Disease, Hemodynamic Monitoring, Goal Directed Therapy
- Trial name
- OPCAB (NCT00624494)
- Testing
- Conventional monitoring, Advanced monitoring
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Surgical Procedures, Operative
Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Spine Surgery
This study evaluates whether using information from a special arterial blood pressure monitor to guide how much fluid is given during surgery changes how long a patient stays in the hospital after the surgery.
- Trial name
- NCT01124474
- Testing
- goal directed therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Nociceptive Pain, Goal-directed Therapy
Nol-Index Guided Remifentanil Analgesia Versus Standard Analgesia During Moderate-to-High Risk Cardiovascular Surgery
This study will investigate the potential of guiding remifentanil analgesia during cardiac and vascular surgery in moderate to high risk patients requiring general anesthesia.
- Conditions
- Nociceptive Pain, Goal-directed Therapy, Hemodynamic Instability, Nol-Index
- Trial name
- NCT04137991
- Testing
- Nol-Index guided analgesia, Standard Analgesia
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Erasme University Hospital
Hypotension During Surgery
Post Anaesthesia Care Hypotension Prevention
The goal of this clinical trial is to investigate if the use of the hypotension prediction index during the perioperative period leads to a decrease in hypotension both during and after surgery (24 hrs) in adults undergoing major…
- Trial name
- PACH-1 (NCT05844774)
- Testing
- HPI (using HemoSphere) - guided algorithm, Treatment of hypotension following standard of care
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Abdominal Aortic Aneurysm Uncomplicated
Goal Directed Therapy for Patients Undergoing Major Vascular Surgery
The management and delivery of intravenous fluids during surgical operations is one of the important duties for anesthesiologists.
- Trial name
- NCT01681251
- Testing
- Fluid titrated with the use of arterial pulse contour cardiac output monitor if SVV >13%, Fluid titrated at the discretion of the attending anesthesiologist
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Postoperative Morbidity, Postoperative Mortality
Fluid Loading in Abdominal Surgery: Saline Versus Hydroxyethyl Starch (FLASH Study)
The primary purpose of the study is to evaluate whether the type of fluid (0.9% saline or 6% Hydroxyethyl starch 130/0.4) in the context of an individualized goal-directed fluid therapy is associated with a difference in…
- Trial name
- FLASH (NCT02502773)
- Testing
- Hydroxethyl starch
- Where
- France
- Volunteers
- 826 people
- Sponsor
- University Hospital, Clermont-Ferrand
Goal Directed Fluid Therapy
Assisted Fluid Management in Patients Undergoing Major Abdominal and Orthopedic Surgery
This study will compare a group of patients managed with a manual GDFT protocol (using the EV1000 monitoring device; Edwards Lifesciences, Irvine, USA) to a group of patients managed using a decision support system for GDFT…
- Trial name
- AFM (NCT03779373)
- Testing
- Use of a decision support system on the EV1000 monitor (AFM mode)
- Where
- France
- Sponsor
- Erasme University Hospital
Severe Sepsis, Emergency
Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery
This study wants to compared the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in septic patients requiring emergency surgery.
- Conditions
- Severe Sepsis, Emergency, Surgery
- Trial name
- NCT01654003
- Testing
- CONTROL, OPTIMIZED
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Stroke Volume Variation
Study of the Natural Variation in Strokevolume
We would like to investigate the natural variation in the strokevolume of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in strokevolume, after a…
- Trial name
- NCT00447200
- Testing
- Esophagus Doppler monitoring, Fluid optimization
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Goal-directed Fluid Therapy
Stroke Volume Variation- Guided Hemodynamic Therapy Versus Oxygen Extraction Ratio-guided Hemodynamic Therapy
The FloTrac/Vigileo is a minimal invasive device assessing flow based hemodynamic parameters by pulse contour analysis based on the radial artery pressure signal.
- Trial name
- NCT05487924
- Testing
- SVV-GDHT, O2ER-GDHT, conventional care
- Volunteers
- 610 people
- Sponsor
- Beijing Tongren Hospital
Sepsis
Early Goal Directed Therapy in Sepsis by Emergency Medical Services
The goal is to evaluate the best way for paramedics and hospitals to work together to treat septic patients as quickly as possible.
- Trial name
- NCT02266654
- Testing
- IV fluids, Hospital Notification
- Where
- United States
- Sponsor
- Massachusetts General Hospital