Clinical trials: Goal Directed Therapy, open to volunteers
Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM)
Goal-Directed Therapy to Reduce Kidney and Cardiovascular Risk in Diabetic Kidney Disease (GOLD-STANDARD)
GOLD-STANDARD is a pragmatic, open-label pilot randomized controlled trial evaluating the feasibility, safety, and implementation of an early goal-directed Cardio-Kidney-Metabolic (CKM) care strategy compared with usual care in…
- Conditions
- Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
- Trial name
- GOLD-STANDARD (NCT07434791)
- Testing
- Early goal-directed Cardio-Kidney-Metabolic (CKM) care, Standard care (Comparison arm)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Bone Tumor, Acute Normovolemic Hemodilution
A Substudy of the Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of perioperative anemia has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone tumor surgery.
- Conditions
- Bone Tumor, Acute Normovolemic Hemodilution, Goal-Directed Fluid Therapy
- Trial name
- NCT06881498
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Surgery Complications
Effects of GDHT (Goal Directed Hemodynamic Therapy) Using a Non-invasive Hemodynamic Monitoring in Elective Neurosurgery
This study aims to assess the safety and efficacy of GDHT using the non-invasive Starling™ SV System in elective neurosurgery. The tested group of patients (n=70) will be compared with a control group (n=70), where hemodynamic…
- Trial name
- NCHGDT (NCT07101991)
- Testing
- Standard monitoring, Goal-Directed Therapy
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Brno University Hospital
Fluid Responsiveness, Laparoscopic Surgery
Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge
Background Fluid management is central to perioperative care, but only about half of surgical patients increase their stroke volume after a fluid challenge.
- Conditions
- Fluid Responsiveness, Laparoscopic Surgery, Hemodynamic Monitoring
- Trial name
- FLUID-LAP (NCT07911059)
- Volunteers
- 104 people
- Sponsor
- University Of Perugia
Parkinson Disease (PD)
Passive Versus Active Music Therapy Parkinson's Disease
The purpose of this pilot study is to identify the effects of active versus passive music therapy on functional ability and psychophysiological responses to goal-directed exercise in people with Parkinson's disease.
- Trial name
- NCT07661524
- Testing
- Passive music therapy, Active music therapy
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
High-risk Lung Resection Surgery
Advanced Goal-Directed Impedancemetry Strategy for Lung Resection Surgery
High-risk patients scheduled for lung resection surgery are increasing and theoretically eligible to perioperative individualized goal-directed fluid therapy (GDFT).
- Trial name
- AEGIS (NCT06156943)
- Testing
- individualized goal-directed fluid therapy by Starling device, group managed by standard of care
- Where
- 10 sites in France
- Volunteers
- 722 people
- Sponsor
- Hospices Civils de Lyon
Elective Major Abdominal Surgery
Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal Surgery Patients in the ICU.
This study aims to compare two different methods for guiding intravenous (IV) fluid therapy in patients during their first 6 hours in the ICU after major abdominal surgery.
- Trial name
- NCT07303855
- Testing
- Goal-Directed Fluid Therapy (GDFT)
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Circulatory Failure / Shock State, Fluid Therapy
Metabolic Fluid Responsiveness in Children
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery.
- Trial name
- METAFRIC (NCT07255469)
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bordeaux
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Lung Ultrasound, Goal Directed Therapy
Lung Ultrasound-guided Hemodynamic Optimization
The formalized expert recommendation of the French Society of Anesthesia and Intensive Care recommends guiding vascular filling by measuring the stroke volume (SV) in surgical patients considered at high risk.
- Conditions
- Lung Ultrasound, Goal Directed Therapy, Non-cardiac Surgery
- Trial name
- POINTBAR (NCT05481723)
- Testing
- noradrenaline and vascular filling, pulmonary ultrasound after vascular filling
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Goal Directed Therapy, Postoperative Morbidity
Risk Factors for Postoperative Complications in Major Non-cardiac Surgery: Post-hoc Analysis of the OPHIQUE Multicentre Study
Post-operative morbidity and mortality is related to many factors related to the patient's condition, the intra-operative period and the optimisation of intra-operative haemodynamic and respiratory parameters.
- Conditions
- Goal Directed Therapy, Postoperative Morbidity, Individualised Target, Postopera Mortality
- Trial name
- MULTIPAS (NCT05824260)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Normovolemic Hemodilution, Bone Tumor
The Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of intraoperative allogenetic blood transfusion has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone cancer surgery.
- Conditions
- Acute Normovolemic Hemodilution, Bone Tumor, Goal-Directed Fluid Therapy, Transfusion
- Trial name
- NCT06459141
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intraoperative Hypotension, Acute Kidney Injury
Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension
In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS.
- Conditions
- Intraoperative Hypotension, Acute Kidney Injury, Myocardial Injury After Non-cardiac Surgery
- Trial name
- Clearsight (NCT06291714)
- Testing
- GDT-based hemodynamic management based on Clearsight device
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Giessen
Circulatory Failure, Shock State
Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children
In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children.
- Conditions
- Circulatory Failure, Shock State, Fluid Therapy
- Trial name
- FAST (NCT07522580)
- Testing
- validation a test of fluid-responsiveness in critically ill children
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Complications, Pulmonary Complication
Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary Surgery
This prospective randomized controlled study aims to compare the effect of low-dose norepinephrine combined with conservative goal-directed fluid therapy versus conventional fluid therapy on postoperative pulmonary complications…
- Trial name
- NCT07892586
- Testing
- Conventional Fluid Therapy, Low-Dose Norepinephrine, Conservative Goal-Directed Fluid Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Esophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)
Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients
Brief Summary This clinical trial aims to evaluate whether perioperative goal-directed fluid therapy (GDFT) targeting a venous excess ultrasound (VExUS) score of 1 can reduce postoperative pulmonary complications (PPCs) in…
- Trial name
- NCT07691944
- Testing
- VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
- Volunteers
- 126 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Noradrenaline
Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver Transplantation
goal-directed fluid therapy has demonstrated benefits on postoperative organ function, vasopressor support with norepinephrine is commonly employed to maintain perfusion pressure, though its renal impact in this setting remains…
- Trial name
- NE AKI in LDLT (NCT07885657)
- Testing
- Norepinephrine started prophylactically immediately post induction of general anesthesia, Norepinephrine infusion will only initiated if mean arterial pressure <65 mmHg despite preload optimization (stroke volume variation <12%) or if systemic vascular resistance <800 dynes•s/cm⁵
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Mitral Valve Insufficiency
To Evaluate the Efficacy and Safety of the Transfemoral Mitral Valve Repair System in the Treatment of Patients With Moderately Severe and Severe Functional Mitral Regurgitation(FMR) Who Remained Clinically Symptomatic After Guideline-directed Medical Treatment
To confirm the effectiveness and safety of the transcatheter mitral valve repair system for the treatment of chronic moderate to severe (3+) or severe (4+) functional mitral regurgitation (FMR) who remained clinically symptomatic…
- Trial name
- NCT05508438
- Testing
- Transfemoral mitral-valve repair
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Pan Xiangbin