Clinical trials: Graft Function
Coronary Artery Disease, Mitral Valve Insufficiency
Mitral Valve Repair Combined Coronary Artery Bypass Grafting(CABG) Verus CABG Alone on Functional Ischemic Mitral Regurgitation
Coronary artery bypass grafting(CABG) is an effective procedure in treating severe coronary artery disease(CAD). Optimal surgical method for CAD patients with functional ischemic mitral regurgitation(FIMR) is still controversial.
- Trial name
- NCT03525041
- Testing
- CABG, mitral valve annuloplasty
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Anzhen Hospital
Kidney Graft
Impact of Perioperative Organ Resuscitation of Brain-dead Deceased Organ Donor on Kidney Graft Function in the Recipient
Brain-dead patients are the primary source of grafts for those awaiting organ transplantation. Recommendations exist for the management of these potential donors, based on the concept of organ resuscitation, according to which…
- Trial name
- OPTI-PMO 2 (NCT06907758)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Blood Pressure Control, Kidney Transplant Recipient
Chronotherapy Versus Conventional BP Control to Correct Abnormal Circadian BP Pattern in Kidney Transplant Recipients
The purpose of this study is to identify and manage factors related to blood pressure control that impact organ function and survival in kidney transplant recipients.
- Trial name
- NCT01093703
- Testing
- Medication Adjustment
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Mayo Clinic
Stem Cell Transplantation, Hematopoietic, Poor Graft Function
MSCs With or Without Peripheral Blood Stem Cell for Treatment of Poor Graft Function and Delayed Platelet Engraftment
The purpose of this study is to compare the efficacy of mesenchymal stem cells (MSCs) with or without granulocyte colony-stimulating factor (G-CSF) mobilized peripheral stem cells (PBSC) in treating patients experiencing poor…
- Conditions
- Stem Cell Transplantation, Hematopoietic, Poor Graft Function, Delayed Platelet Engraftment, Hematological Diseases
- Trial name
- NCT02240992
- Testing
- PBSC, MSCs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Hepatitis B
A Clinical Study Evaluating the Pharmacokinetic Characteristics and Safety of AHB-137 Injection in Participants With Mild to Moderate Liver Dysfunction and Those With Normal Liver Function.
A clinical study evaluating the pharmacokinetic characteristics and safety of AHB-137 injection in participants with mild to moderate liver dysfunction and those with normal liver function.
- Trial name
- NCT07600788
- Testing
- AHB-137 injection
- Where
- 5 sites in China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ausper Biopharma Co., Ltd.
Delayed Graft Function
A Pilot Study Comparing the Safety and Efficacy of Everolimus With Other Medicines in Recipients of ECD/DCD Kidneys
The purpose of this pilot study is to evaluate concentration-controlled everolimus with low dose tacrolimus compared to early conversion to CNI-free regimen and MMF/MPA with standard dose tacrolimus in de novo renal transplant…
- Trial name
- Evered (NCT01878786)
- Testing
- Everolimus, Tacrolimus, Mycophenolate mofetil (MMF/MPA)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Matthew Cooper
Antibody-mediated Rejection
TocIlizumab in Late/Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients
This multi-center study is an investigator-driven randomized controlled parallel group open-label clinical trial designed to evaluate the efficacy of addition of anti-IL-6 antibody tocilizumab (TCZ) to the standard of care (SOC)…
- Trial name
- INTERCEPT (NCT04561986)
- Testing
- Tocilizumab
- Where
- 6 sites in Spain, Sweden
- Volunteers
- 50 people
- Sponsor
- Vastra Gotaland Region
Posttransplant Diabetes Mellitus, Acute Graft Rejection
Silymarin's Advantage on Graft Effectiveness
The study examines the impact of silymarin supplementation during the early post-transplant period, administering 900 g daily for 30 days under standard treatment.
- Conditions
- Posttransplant Diabetes Mellitus, Acute Graft Rejection, Biopsy Proven Acute Rejection, Antibody Mediated Rejection of Kidney Transplant
- Trial name
- SAGE (NCT06801886)
- Testing
- Silymarine supplementation
- Where
- Slovakia
- Volunteers
- 130 people
- Sponsor
- University Hospital, Martin
Acute Rejection of Renal Transplant, Graft Failure
Dd-cfDNA and Treg in Prediction of Kidney Transplant Acute Rejection
Acute rejection after kidney transplantation should ideally be diagnosed prior to immunologic injury in a non-invasive fashion in order to improve long-term graft function.
- Trial name
- NCT05084768
- Testing
- Donor-derived cell-free DNA
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Loma Linda University
End-stage Renal Disease
Eplerenone in Patients Undergoing REnal Transplant (EPURE TRANSPLANT)
Assess the impact of eplerenone (initiated within 2 hours prior to patient departure to the operating room and administered for 4 days during the post-operative period) on graft function evaluated by the measurement of glomerular…
- Trial name
- EPURE (NCT02490904)
- Testing
- Eplerenone
- Where
- 7 sites in France
- Volunteers
- 132 people
- Sponsor
- Central Hospital, Nancy, France
Delayed Graft Function, Other Complication of Kidney Transplant
I5NP for Prophylaxis of Delayed Graft Function in Kidney Transplantation
The purpose of this study is to determine whether a single administration of QPI-1002 (also known as I5NP) can prevent DGF in patients undergoing deceased donor kidney transplantation.
- Trial name
- NCT00802347
- Testing
- I5NP, Saline
- Where
- 50 sites in United States, Canada and 3 more
- Volunteers
- 374 people
- Sponsor
- Quark Pharmaceuticals
Tricuspid Regurgitation, Tricuspid Regurgitation Functional
Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)
Early Feasibility Study to evaluate the safety and performance of the Innoventric Trillium™ Stent Graft in the treatment of severe or greater tricuspid regurgitation (TR).
- Trial name
- NCT06212193
- Testing
- Trillium™
- Where
- 10 sites in United States, Germany
- Volunteers
- 25 people
- Sponsor
- Innoventric LTD
Coronary Artery Disease, Decreased Left Ventricular Function
Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass
GLP-1 has not only beneficial effects on glucose metabolism but also direct positive effects on cardiac function and metabolism in both experimental models and in patients with type 2 diabetes mellitus.
- Trial name
- Executive (NCT01373216)
- Testing
- Exenatide
- Where
- Czechia
- Volunteers
- 38 people
- Sponsor
- Charles University, Czech Republic
Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy
Nerve Grafting Technique to Restore Erectile Function Post Radical Prostatectomy
A single arm prospective pilot trial evaluating the safety and the 1-year erectile recovery outcomes of patients undergoing a somatic to autonomic nerve grafting procedure for restoration of erectile function in patients who have…
- Trial name
- PRP-NR (NCT06458855)
- Testing
- Post radical prostatectomy nerve restoration procedure (PRP-NR)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Mechanical Complication of Coronary Artery Bypass Graft, Respiratory Depression
Effects of Osteopathic Treatment on Pulmonary Function After Coronary Artery Bypass Graft Surgery
The purpose of this study is to determine the short and long term effects of osteopathic treatment on pulmonary function, pain and quality of life in patients after coronary artery bypass graft (CABG) surgery.
- Conditions
- Mechanical Complication of Coronary Artery Bypass Graft, Respiratory Depression, Pain, Quality of Life
- Trial name
- OSTinCARE (NCT01714791)
- Testing
- Usual care, Osteopathic treatment
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Hartcentrum Hasselt
Liver Graft Dysfunction
Delayed CNI-based Immunosuppression With Advagraf After MELD-based Liver Transplantation
Prolonged-release low-dose Advagraf should better protect from CNI-side effects compared to standard immunosuppressive regiments while the rate of rejection is not increased and thus graft function is well maintained.
- Trial name
- IMUTECT (NCT01781195)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Surgery, Oral
Composite Tissue Allotransplantation of the Face: Anatomical and Functional Evaluation
In hindsight, the first "face graft" raises the fundamental problem of composite tissue allotransplantation (hand, larynx, abdominal wall, etc.) with the addition of specific technical and philosophical problems.
- Trial name
- AFTC (NCT02818400)
- Testing
- composite tissue allotransplantation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Type 1 Diabetes (T1D)
Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events.
- Trial name
- ISLET-TITR (NCT07470593)
- Testing
- Continuous glucose monitoring (CGM) with TITR measurement
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Strasbourg, France
Delayed Graft Function, DGF
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
The primary objective of this study is to demonstrate the efficacy of ravulizumab vs placebo in reducing the severity of DGF as measured by time to freedom from dialysis in adult participants who are at high risk of DGF after…
- Conditions
- Delayed Graft Function, DGF, Kidney Transplant
- Trial name
- AWAKE (NCT06830798)
- Testing
- Ravulizumab
- Where
- 130 sites in United States, Argentina and 16 more
- Volunteers
- 450 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Coronary Disease, Myocardial Infarction
Stem Cell Therapy to Improve Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting (CABG)
The purpose of this study is to determine whether intracoronary transfer of autologous bone marrow cells can induce angiogenesis, subsequently improving regional myocardial perfusion, and finally resulting in improved systolic…
- Trial name
- NCT00395811
- Testing
- Bone Marrow Stem Cell Therapy combined CABG
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China National Center for Cardiovascular Diseases