Clinical trials: Graft Function
Coronary Artery Bypass Graft, CABG
High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease
Background/aim: Endothelial function is closely associated with coronary artery health among individuals being treated for heart disease.
- Trial name
- NCT06127147
- Testing
- IMT
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Illinois Chicago
Thoracic Surgery, Postoperative Period
Efficacy of Triburter on Respiratory Muscle Function in Patients After CABG in Cardiac Rehabilitation Phase II
Post-surgery patients have muscle impairments, especially in the respiratory muscles, because the anesthesia, surgical incision, mechanical ventilation, pain, and prolonged postures, affect the mechanical condition of respiratory…
- Conditions
- Thoracic Surgery, Postoperative Period, Weakness, Muscle
- Trial name
- NCT05496049
- Testing
- Triburter, Incentive spirometry
- Where
- Colombia
- Volunteers
- 30 people
- Sponsor
- Fundación Cardiovascular de Colombia
Type 1 Diabetes (T1D)
Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events.
- Trial name
- ISLET-TITR (NCT07470593)
- Testing
- Continuous glucose monitoring (CGM) with TITR measurement
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Strasbourg, France
Coronary Artery Disease, Chronic Kidney Disease
Effects of Surgical, Percutaneous or Medical Treatments for Coronary Artery Disease on Renal Function: Long-Term Outcome. Cardiorenal-trial.
Background: Coronary artery disease (CAD) is treated with coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT).
- Trial name
- NCT07195747
- Testing
- Creatinine
- Where
- Brazil
- Volunteers
- 1,700 people
- Sponsor
- Instituto do Coracao
Kidney Transplantation, ESRD
Donor Dopamine and Initial Graft Function
Donor pre-treatment with dopamine reduces injury to the kidney graft with consequences on the clinical performance immediately after transplantation: Donor dopamine reduces the requirement of dialysis post transplant, and results…
- Trial name
- NCT00115115
- Testing
- Dopamine infusion to brain dead organ donors
- Where
- Germany
- Volunteers
- 487 people
- Sponsor
- Universitätsmedizin Mannheim
Stroke, Chronic
Effects of Dualsite Anodic tDCS on Lower Limbs Function in Patients After Stroke: Randomized, Double-blind, Placebo-controlled, Crossover Trial
It is currently known that Transcranial Direct Current Stimulation (tDCS) can modulate cortical activity, being considered an important resource in the treatment of sequelae resulting from stroke.
- Trial name
- NCT04850963
- Testing
- Transcranial direct current stimulation (Anodal tDCS) + dual-task training, Transcranial direct current stimulation (tDCS dualsite) + dual-task traning
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Kidney Graft Dysfunction
Histology of Implantation Biopsies and Kidney Allograft Outcomes
The morphology of transplanted kidney is considered to be important for graft outcomes in early and late posttransplant period. Individual histological lesions at the time of kidney transplantation, such as sclerosis of…
- Trial name
- KALIMBO (NCT03155763)
- Testing
- Intraoperative kidney allograft preimplantation biopsy; Intraoperative kidney allograft postreperfusion biopsy
- Where
- Ukraine
- Volunteers
- 130 people
- Sponsor
- Andriy Trailin
Islet Transplantation
Effect of Sitagliptin on Graft Function Following Islet Transplantation
Islet transplantation requires a large number of islets required to achieve insulin independence and the function of the transplanted islets progressively declines over time.
- Trial name
- NCT00853944
- Testing
- sitagliptin
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Chronic Kidney Insufficiency
Non-interventional-study With Tacrolimus Sandoz© Capsules for Prophylaxis of Renal Graft Rejection
This non-interventional study intends to collect epidemiological data in patients with stable kidney function after renal transplantation, who receive Tacrolimus Sandoz© according to the approved indication.
- Trial name
- NCT01353417
- Testing
- In this observational study no study specific intervention is planned
- Where
- Austria
- Volunteers
- 102 people
- Sponsor
- Sandoz
Kidney Transplant
Intensive Insulin Therapy in Deceased Donors
Every year in the US, there is a shortage of many thousands of kidneys needed for transplant. Furthermore, kidneys that are available and are transplanted often exhibit delayed or slow graft function (DGF and SGF, respectively)…
- Trial name
- NCT01140035
- Testing
- Administration of continuous insulin infusion for glycemic control in brain dead donors
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Hemiparesis, Ischemic Stroke
Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily Living
The investigators will study motor recovery after robot-assisted therapy after stroke. A small clinical trial will be conducted to quantify the central nervous system changes associated with robotic or standard training, and…
- Conditions
- Hemiparesis, Ischemic Stroke, Chronic
- Trial name
- NCT00878085
- Testing
- Robot Therapy Device, Occupational Therapy
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Delayed Graft Function, Kidney Transplant; Complications
The Frequency and Risk Factors of Delayed Graft Function
Delayed graft function (DGF) is an important phenomenon after kidney transplantation with direct and indirect implication on graft survival.
- Trial name
- NCT03555513
- Testing
- living kidney transplantation
- Volunteers
- 500 people
- Sponsor
- nooshin dalili
Nephrectomy
Recovery of Short-term Renal Function in Post-transplant Patients Living Donor
Objectives: To describe and analyze the perioperative and functional evolution of short-term renal graft in patients with kidney transplantation from a live donor, comparing three surgical techniques for obtaining kidney graft…
- Trial name
- NCT03717259
- Testing
- Open nephrectomy, Hand-assisted laparoscopic nephrectomy, Laparoscopic nephrectomy
- Volunteers
- 508 people
- Sponsor
- Instituto Mexicano del Seguro Social
Function of Renal Transplant
Protocol Calcineurin Inhibitor (CNI) Weaning
The main objective of this study is to demonstrate the benefit of the withdrawal of Tacrolimus (Prograf®) on renal function in patients one year after the end of the weaning period.
- Trial name
- NCT01292525
- Testing
- Tacrolimus
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Nantes University Hospital
Renal Failure Chronic, Transplant;Failure,Kidney
Enhancing Renal Graft Function During Donor Anesthesia
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney.
- Conditions
- Renal Failure Chronic, Transplant;Failure,Kidney, Anesthesia
- Trial name
- NCT03778944
- Testing
- Mannitol infusion, Dopamine infusion, Adequate hydration
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Nazmy Edward Seif
Delayed Graft Function
Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function
When a patient receives a kidney transplant particularly if the kidney is from an older donor or one who has had the kidney removed after their heart has stopped, there is a risk that the newly transplanted kidney may not…
- Trial name
- NCT01794663
- Testing
- OPN-305
- Where
- 50 sites in United States, Austria and 9 more
- Volunteers
- 252 people
- Sponsor
- Opsona Therapeutics Ltd.
Graft Dysfunction, Lung Transplantation
Prediction of Lung Transplant Outcome
Plain Language Summary of the PLUTO Study Prediction of Lung Transplant Outcomes (PLUTO) What is this study about? This study aims to improve how doctors predict the health of lung transplant recipients over time.
- Conditions
- Graft Dysfunction, Lung Transplantation, Chronic Lung Allograft Dysfunction (CLAD), Chronic Rejection of Lung Transplant
- Trial name
- PLUTO (NCT07356752)
- Testing
- Research Blood Sampling and Biocollection
- Where
- 9 sites in France
- Volunteers
- 4,200 people
- Sponsor
- Hopital Foch
Hepatitis C
Cognitive Impairments in Chronic Hepatitis C Patients and Potential Reversibility With New Agents (CICHepC)
The overall aim of this study is to evaluate the prevalence of cognitive impairments and brain anomalies in Chronic Hepatitis C infected individuals and to investigate likely changes in cognition and brain structure and function…
- Trial name
- CICHepC (NCT02745132)
- Testing
- Neuropsychological evaluation and Brain MRI
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis
Effects of Exercise Training on Left Ventricular Function in Type 2 Diabetic Patients Post Coronary Artery Bypass Graft
The purpose of this study is to investigate the changes of cardiorespiratory fitness and left ventricular function in type 2 diabetes after uncomplicated coronary artery bypass graft (CABG) surgery.
- Conditions
- Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Post Coronary Artery Bypass Grafting
- Trial name
- NCT00172536
- Testing
- Exercise training, Control
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
End Stage Chronic Renal Failure, Renal Transplant
Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function
This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery.
- Conditions
- End Stage Chronic Renal Failure, Renal Transplant, Microvascular Changes, Microvascular Circulation
- Trial name
- MUST-D (NCT07645599)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound), Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Lumason® contrast agent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Roderick Tan