Clinical trials: Granulomatosis With Polyangitis
Pulmonary Healthy Controls, Interstitial Lung Disease
Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)
Current diagnostic tools used in interstitial lung disease (ILD) do not meet the challenges set by the complex pathophysiology of this heterogenous group.
- Conditions
- Pulmonary Healthy Controls, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Non-specific Interstitial Pneumonia
- Trial name
- NCT02827734
- Testing
- multiple breath washout tests, impulse oscillometry, body plethysmography
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Glomerulonephritis Acute
Urinary T Cell Biomarker for Prediction in ANCA Glomerulonephritis
Urinary T lymphocytes may be predictive for clinical outcome in patients with ANCA associated glomerulonephritis (ANCA GN). The investigators hypothesize that the amount of CD4+ effector/memory T cells in urine at time of…
- Trial name
- NCT04320667
- Testing
- Flow cytometry analysis of urine samples
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 79 people
- Sponsor
- Charite University, Berlin, Germany
EGPA - Eosinophilic Granulomatosis With Polyangiitis
eGPA and Local Inflammation Within the Ear, Nose and Throat Area
Rationale: Eosinophilic Granulomatosis with Polyangiitis (eGPA), eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are airway diseases where eosinophils and interleukine-5 are involved in the pathogenesis.
- Trial name
- NCT06298448
- Testing
- laboratory experiments before and after mepolizumab treatment
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
ANCA Associated Systemic Vasculitis, Wegener's Granulomatosis
Pulse Versus Continuous Cyclophosphamide for Induction of Remission in ANCA-Associated Vasculitides
A comparison of intermittent pulsed cyclophosphamide to daily oral cyclophosphamide for the treatment of ANCA-associated systemic vasculitides with kidney involvement. Performed by the European Vasculitis Study group.
- Conditions
- ANCA Associated Systemic Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis
- Trial name
- NCT00430105
- Testing
- cyclophosphamide
- Volunteers
- 160 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Wegener's Granulomatosis
Daclizumab to Treat Wegener's Granulomatosis
This study will examine the safety and effectiveness of daclizumab (also called Zenapax or anti-CD25) in patients with Wegener's granulomatosis, a type of vasculitis (blood vessel inflammation).
- Trial name
- NCT00040248
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Wegeners Granulomatosis (Granulomatosis With Polyangiitis), Microscopic Polyangiitis
Pediatric Vasculitis Initiative
Childhood chronic vasculitis describes a group of rare life-threatening diseases that have in common inflammation of blood vessels in vital organs such as kidneys, lungs and brain.
- Conditions
- Wegeners Granulomatosis (Granulomatosis With Polyangiitis), Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis, Polyarteritis Nodosa
- Trial name
- PedVas (NCT02006134)
- Where
- 32 sites in United States, Canada and 5 more
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Granulomatosis With Polyangiitis, Wegener Granulomatosis
The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach
This is a randomized controlled trial in patients with a diagnosis of granulomatosis with polyangiitis (GPA; Wegener's)that are in remission to evaluate the effects of using low-dose glucocorticoids ( 5 mg/day of prednisone) as…
- Conditions
- Granulomatosis With Polyangiitis, Wegener Granulomatosis, Vasculitis
- Trial name
- TAPIR (NCT01933724)
- Testing
- 5 mg prednisone, 0 mg prednisone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Vasculitis, Systemic Vasculitis
Impact of Vasculitis on Employment and Income
The purpose of this study is to learn about the impact of vasculitis on employment and income in patients with different systemic vasculitides.
- Conditions
- Vasculitis, Systemic Vasculitis, Behcet's Disease, CNS Vasculitis
- Trial name
- NCT02476292
- Testing
- online questionnaire
- Where
- United States
- Volunteers
- 426 people
- Sponsor
- University of South Florida
MPA, PAN or EGPA With FFS=0
Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome)
To determine whether a combination of corticosteroids and azathioprine can achieve a higher remission rate and a lower subsequent relapse rate in patients with newly-diagnosed microscopic polyangiitis, polyarteritis nodosa or…
- Conditions
- MPA, PAN or EGPA With FFS=0, At Diagnosis or Within the First 15 Days Following Initiation of Corticosteroids
- Trial name
- CHUSPAN2 (NCT00647166)
- Testing
- corticosteroid and azathioprine
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ANCA-associated Vasculitis, Granulomatosis With Polyangiitis
PRagmatic Analysis of Vitamin D in ANCA-Associated Vasculitis
This prospective study will assess if 12 months of vitamin D3 (cholecalciferol) supplementation, in patients with AAV (GPA, MPA, and EGPA) who have deficient or insufficient 25(OH)D3 status at enrollment, correlates with improved…
- Conditions
- ANCA-associated Vasculitis, Granulomatosis With Polyangiitis, Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis
- Trial name
- PRAVDA (NCT04280601)
- Testing
- vitamin D
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Christian Pagnoux
EGPA - Eosinophilic Granulomatosis With Polyangiitis
Explore the Efficacy and Mechanism of Action of Tezepelumab in Eosinophilic Granulomatosis With Polyangiitis
RACEMATE is a phase 2b, multicentre, randomised, double-blinded, placebo-controlled study designed to explore the efficacy and mechanism of action of tezepelumab in adults with eosinophilic granulomatosis with polyangiitis (EGPA).
- Trial name
- RACEMATE (NCT06230354)
- Testing
- Tezepelumab
- Where
- 12 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Inflammation, Vasculitis
Steroids and Methotrexate to Treat Systemic Vasculitis
This study will evaluate the safety and effectiveness of prednisone and methotrexate in treating severe Wegener's granulomatosis and other systemic vasculitides.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001256
- Testing
- prednisone and methotrexate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Granulomatosis With Polyangiitis (Wegener's)
Assessing Granulomatosis With Polyangiitis Activity: 18F-FDG PET/CT vs BVAS v3
The goal of this observational study is to quantify activity and extent of disease in patients with GPA using 18F-FDG PET/CT. The main questions it aims to answer are: Sensitivity of 18 F-FDG PET/CT in patients with GPA?…
- Trial name
- NCT07712172
- Testing
- 18F-FDG, 18F-FDG PET/CT
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
ANCA Associated Vasculitis, Granulomatosis With Polyangiitis
Rituximab and Belimumab Combination Therapy in PR3 Vasculitis
Mechanistic study to assess whether dual B-cell immunotherapy by co-administration of rituximab and belimumab will result in improvements in biological endpoints, functional outcomes and clinical status compared to rituximab with…
- Trial name
- COMBIVAS (NCT03967925)
- Testing
- Belimumab, Rituximab, Prednisolone
- Where
- 6 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Rachel Jones
Churg-Strauss Syndrome
Eosinophilic Granulomatosis With Polyangiitis Cohort
EGPA (Eosinophilic Granulomatosis with Polyangiitis, previously Churg-Strauss syndrome) is a rare vasculitis, characterised by asthma, rhinosinusitis and eosinophilia.
- Trial name
- EGPA Cohort (NCT03036670)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Granulomatosis With Polyangitis
Evaluate the Remission MAINtenance Using Extended Administration of Prednisone in Systemic Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis.
Immunosuppressive therapy of granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) has transformed the outcome from death to a strong likelihood of disease control and temporary remission.
- Trial name
- MAINEPSAN (NCT03290456)
- Testing
- Prednisone 5mg/day extended of 12 additional months
- Where
- 45 sites in France
- Volunteers
- 146 people
- Sponsor
- Hospices Civils de Lyon
Vasculitis
Belimumab in Remission of VASculitis
The purpose of this study is to evaluate the efficacy and safety of belimumab, in combination with azathioprine, for the maintenance of remission following a standard induction regimen in patients with Wegener's granulomatosis or…
- Trial name
- BREVAS (NCT01663623)
- Testing
- Belimumab 10 mg/kg, Azathioprine
- Where
- 89 sites in United States, Australia and 18 more
- Volunteers
- 106 people
- Sponsor
- Human Genome Sciences Inc., a GSK Company
ANCA-associated Vasculitis
Abatacept in ANCA Associated Vasculitis
The purpose of this study is to investigate whether abatacept can prevent relapse in patients with ANCA associated vasculitis(AAV). This is a randomised double blinded placebo controlled trial.
- Trial name
- ABAVAS (NCT00482066)
- Testing
- Abatacept (Orencia)
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Imperial College London
Wegener's Granulomatosis, Microscopic Polyangiitis
American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis
Vasculitis is group of diseases where inflammation of blood vessels is the common feature. Patients typically present with fever, fatigue, weakness and muscle and joint aches.
- Conditions
- Wegener's Granulomatosis, Microscopic Polyangiitis, Churg Strauss Syndrome, Polyarteritis Nodosa
- Trial name
- DCVAS (NCT01066208)
- Where
- 120 sites in United States, Argentina and 31 more
- Volunteers
- 3,588 people
- Sponsor
- University of Oxford
Granulomatosis With Polyangiitis (Wegener's), Granulomatosis With Polyangiitis
Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)
Multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of abatacept to achieve sustained glucocorticoid-free remission in patients with relapsing non-severe granulomatosis with polyangiitis…
- Conditions
- Granulomatosis With Polyangiitis (Wegener's), Granulomatosis With Polyangiitis, Wegener's Granulomatosis, ANCA-Associated Vasculitis
- Trial name
- NCT02108860
- Testing
- Abatacept
- Where
- 20 sites in United States, Canada and 3 more
- Volunteers
- 65 people
- Sponsor
- University of South Florida