Clinical trials: Growth & Development
Haemophilia A, Haemophilia B
A Study of the Impact of Hemophilia and Its Treatment on Brain Development, Thinking and Behaviour in Children With Hemophilia
The Hemophilia Growth and Development Study (HGDS) nearly 25 years ago showed haemophilia and HIV impacted brain development, thinking, and behaviour in children and adolescents.
- Trial name
- eTHINK (NCT03660774)
- Testing
- No treatment given
- Where
- 22 sites in United States
- Volunteers
- 563 people
- Sponsor
- Novo Nordisk A/S
Adult Growth Hormone Deficiency
Extension Study on Safety of Long-Term Growth Hormone Replacement in Adult Patients With Growth Hormone Deficiency
To evaluate long-term safety of growth hormone replacement in adult patients with growth hormone deficiency
- Trial name
- NCT00191360
- Testing
- Somatropin
- Where
- 14 sites in Japan
- Volunteers
- 68 people
- Sponsor
- Eli Lilly and Company
COPD, Depression
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
Chronic Obstructive Pulmonary Disease (COPD) is prevalent and debilitating chronic disease in Veterans. COPD is highly co-morbid with depression and anxiety conferring greater morbidity and mortality risk.
- Conditions
- COPD, Depression, Anxiety
- Trial name
- NCT04953806
- Testing
- Step-CBT
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA)
In-Depth Characterisation of Biliary Strictures and Hepato-Pancreato-Biliary Focal Lesions for Development of New Technologies to Tackle Hepato-Pancreato-Biliary Cancers
Hepato-Pancreato-Biliary (HPB) cancers originating in the liver, bile ducts, pancreas, and gall bladder represent a rising global health challenge, with incidence doubling in the UK over the past decade.
- Conditions
- Biliary Tract Cancer (BTC), Biliary Tract Cancer (CCA), Cholangiocarcinoma, Cholangiocarcinoma Cancer
- Trial name
- Map HPB (NCT07206355)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Nottingham
Chronic Total Occlusion of Coronary Artery, Diabetes Mellitus, Type 2
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total…
- Trial name
- COLLECT (NCT06054126)
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Stroke
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a…
- Trial name
- NCT06911385
- Testing
- Arm Remote Ischemic Conditioning plus Pneumatic Compression lower limb
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Traumatic Dental Injury, Autism Spectrum Disorder
Occurrence of Traumatic Dental Injury in a Group of Egyptian Autistic Children Compared to Normal Children: (A Cohort Study)
The aim of the study is to assess the occurrence of traumatic dental Injury in a group of Egyptian Autistic Children compared to normal children. Population: Egyptian children Exposure: Autistic children.
- Conditions
- Traumatic Dental Injury, Autism Spectrum Disorder, Dental Trauma
- Trial name
- NCT04235543
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Autism Spectrum Disorder
Development and Validation of a System for the Anticipation of Challenging Behaviors
Most people with autism spectrum disorder (ASD) present at least one form of challenging behavior (CB). Self-injurious, aggressive, and disruptive CBs linked with social interaction, community-based service exclusion, and a life…
- Trial name
- NCT05340608
- Testing
- Smart, non-invasive shirt - Physiological parameters, Smart, non-invasive shirt - Relation with challenging behaviors, Smart, non-invasive shirt - Proof of Concept
- Where
- Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ariel University
Septicaemia, Deformity of Spine
The Paediatric Refill Study (PRefill)
2 recent national reports 'Why Children Die' and 'Are we there yet?'identified deficiencies in recognising and managing sick children.
- Conditions
- Septicaemia, Deformity of Spine, Trauma
- Trial name
- PRefill (NCT02208817)
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Nottingham
Parkinson Disease
Development and Research of an Individualized Intelligent Platform for Rehabilitaion in Parkinson's Disease
The present study aims to compare the clinical efficacy of intelligent POWER therapy, intelligent LSVT-BIG therapy, and the three exercise models currently in clinical use.
- Trial name
- NCT03212014
- Testing
- LSVT-BIG, POWER, Traditional rehabilitation
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy Volunteers
Imaging Techniques in CT: Technical Development
Background: Computed tomography (CT) scanning is a procedure that helps doctors with diagnoses. It uses X-ray radiation to produce an image in three dimensions.
- Trial name
- NCT02242448
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
T1DM, Brain Development
Brain Health and Development With T1DM
Type 1 diabetes mellitus (T1DM) is typically diagnosed in childhood and over time can lead to complications affecting the retina, heart, kidneys, peripheral nerves, and more recently appreciated, the brain.
- Trial name
- NewT (NCT03335878)
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Glioma
Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas
This is an observational study to compare the utility of the novel aMRI approach in human brain to the standard of care imaging approach for diagnosing and assessing glioma.
- Trial name
- NCT05937776
- Testing
- Fludeoxyglucose F-18, Gadoterate Meglumine, Contrast-enhanced Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- OHSU Knight Cancer Institute
Autism Spectrum Disorder
Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Trial
The goal of this study is to target the neurobiology of restricted and repetitive behaviors in children with autism spectrum disorder using N-acetylcysteine (NAC), a well-tolerated nutritional supplement that has shown promise…
- Trial name
- NCT05664789
- Testing
- N acetyl cysteine
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Stanford University
Stress
The Effects of a Relaxation Intervention on College Students' Social-emotional Competence
Objective: To examine the impact of a psychomotor relaxation program on college students' social-emotional competence, personal and professional development. Participants: Twenty female college students participated.
- Trial name
- NCT05694468
- Testing
- Psychomotor Relaxation
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Évora
Abdominal Surgery
Development of a Patient-Reported Outcome Measure to Assess Recovery After Abdominal Surgery
As surgery enters the era of value-based care, it is advocated that postoperative recovery be measured using patient-reported outcomes (PROs) as they provide a mean to incorporate the patient's perspectives and experiences into…
- Trial name
- NCT03461497
- Where
- 7 sites in United States, Brazil and 3 more
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Stress Disorders, Post-Traumatic, Myocardial Infarction
Myocardial Infarction - Stress Prevention Intervention
Posttraumatic Stress Disorder (PTSD) is a mental disorder that may occur after someone experiences a traumatic event. Between 10-20% of patients may develop PTSD in response to the traumatic experience of myocardial infarction…
- Trial name
- MI-SPRINT (NCT01781247)
- Testing
- Minimal behavioral intervention, Control intervention
- Where
- Switzerland
- Volunteers
- 190 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Injections, Spinal, Cancer
Place of Intrathecal Analgesia to Improve the Quality of Life of Painful Cancer Patients
The intrathecal analgesia is a recommended technic to treat persistent pain in cancer patient but little used, whose the technical conditions require hospital multidisciplinary expertise and coordination associated to a link…
- Trial name
- QUALITHEC01 (NCT04388449)
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Institut Cancerologie de l'Ouest
Autism Spectrum Disorder
Assessment of the Usability/acceptability of the Little Journey App by Parents/guardians/legal Representatives and Children Aged Between 3-12 Years Old Who Have a Diagnosis of Autism Spectrum Disorder (ASD).
Assessment of the usability/ acceptability of the Little Journey app with children aged between 3-12 years old with a diagnosis of autism spectrum disorder (ASD) and experience of attending hospital for a procedure, and their…
- Trial name
- NCT06598358
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Little Journey
To Predict Early Post-hepatectomy Mortality for HCC
Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection
Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma.
- Trial name
- NCT06621485
- Where
- China
- Volunteers
- 4,966 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital