Clinical trials: Guideline Implementation, open to volunteers
Type 2 Diabetes (T2DM)
Implementing WHO HEARTS-D Guidelines in Bangladesh for Diabetes Control and Prevention
Type-2 diabetes (T2D) is rising at an alarming rate in the low- and middle-income countries (LMIC). This rapid increase in the T2D burden has a particular impact on cities, where more than half the LMIC populations currently live…
- Trial name
- T2D IR (NCT07155902)
- Testing
- The community-to-facility integrated strategy
- Volunteers
- 5,000 people
- Sponsor
- Florida International University
Heart Failure
Registry BAsed Optimization Of Therapy in Heart Failure
Rationale. Although several pharmacological treatments, namely renin-angiotensin-system inhibitors, sacubitril/valsartan, beta-blockers, mineralocorticoid receptor antagonists and sodium-glucose cotransporter-2 inhibitors…
- Trial name
- REBOOT-HFrEF (NCT07154758)
- Testing
- Screening for need of HFrEF GDMT implementation through SwedeHF
- Where
- 6 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Region Stockholm
Cancer, Abdominal Cancer Surgery
Developing Pilot Postoperative Guidelines for Improved Functional Outcomes After High-Risk Cancer Surgery
The objective of this study is to develop and evaluate the implementation of novel timeline-specific National Comprehensive Cancer Network (NCCN)-style clinical guidelines designed to improve functional outcomes after high-risk…
- Conditions
- Cancer, Abdominal Cancer Surgery, Surgery, Recovery Outcomes
- Trial name
- NCT07720089
- Testing
- Algorithmic Guideline for Functional Recovery following Cancer Surgery
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Alabama at Birmingham
Chronic Kidney Disease, Type 2 Diabetes
RAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)
The goal of this pragmatic randomized clinical trial is to determine whether an Epic-based clinician notification increases initiation of guideline-directed cardio-kidney-metabolic (CKM) therapies in adults with type 2 diabetes…
- Trial name
- NCT07605390
- Testing
- Epic-Based Clinician Notification, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Baylor Research Institute
Nurse Based Care Management, Patient Care
Bring Sleep to Life - Evaluation and Description of a Sleep Intervention in Emergency Care
Many patients complain of poor sleep during their hospital stay. Therefore, we want to investigate how we can improve the staff's (nurses and assistant nurses) knowledge about sleep and which nursing interventions can lead to…
- Conditions
- Nurse Based Care Management, Patient Care, Intervention, Education, Professional
- Trial name
- NCT07265713
- Testing
- Knowledge about sleep guideline, Introduction of web-based sleep education
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Karolinska University Hospital
Post-ERCP Acute Pancreatitis
ESGE-Quality Improvement in Endoscopy: ERCP
The primary aim of the present study is to compare the incidence of post-ERCP pancreatitis (PEP) before and after the implementation of the QIC-guideline in 2017: "Performance measures for ERCP and endoscopic ultrasound: a…
- Trial name
- QIC_ERCP (NCT06727851)
- Where
- Germany
- Volunteers
- 1,254 people
- Sponsor
- Universität Münster
Cardiovascular Diseases
Proactive Population Health Management of Cardiovascular Disease in Primary Care Using the PROSPERA-program.
The PROSPERA-program is a complex multilevel approach that includes training for healthcare providers, a risk assessment process, and decision support tools to help match patients with the appropriate treatment based on their…
- Trial name
- PROSPERA (NCT06593704)
- Testing
- PROSPERA-program
- Where
- Netherlands
- Volunteers
- 848 people
- Sponsor
- Leiden University Medical Center
Myocardial Infarction, Risk Reduction
The Perfect-CR Implementation Study
The goal of this open-label cluster-randomized effectiveness-implementation hybrid trial is to study whether a) audit and feedback of cardiac rehabilitation service delivery within a national quality registry and b) structured…
- Trial name
- NCT05889416
- Testing
- Audit and feedback through a quality registry, Implementation support
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Skane University Hospital
Neonatal Patients Undergoing Major Non-cardiac Surgery, Congenital Anomaly
Neonatal Enhanced Recovery After Surgery (ERAS) Outcomes Study
The goal of this observational study is to improve the way newborn babies are cared for before, during, and after major surgery. Surgery can be very stressful on a baby's body.
- Trial name
- NEO (NCT07771478)
- Testing
- Pre-nERAS Guideline Implementation Intervention, Multifaceted Implementation of nERAS Guideline Intervention
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 400 people
- Sponsor
- The Hospital for Sick Children
Sports-related Concussion
Harmonization and Implementation of Sports-related Concussion Guidelines in European Football for Youth - the Erasmus + Project
This study addresses the evident gap in SRC awareness and reporting, especially at the grassroots level, by harmonizing concussion management practices across Europe and observing its impact on stakeholders' (coaches, parents…
- Trial name
- REFORM (NCT07128706)
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Type 2 Diabetes, Cardiovascular Complication
Effects and Safety of Diabetic GUideline Algorithm Implementation Performed by Primary Care Physicians in the Community
The Effects and Safety of Diabetic GUideline Algorithm Implementation in the Community (GUARD-Community) study is a 2-arm, cluster-randomized control trial to evaluate the effect and safety of guideline algorithm intervention…
- Conditions
- Type 2 Diabetes, Cardiovascular Complication, Diabetic Kidney Disease
- Trial name
- GUARD (NCT05349955)
- Testing
- Intensive guideline algorithm implementation, Conventional guideline algorithm implementation
- Where
- 13 sites in China
- Volunteers
- 5,600 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure With Reduced Ejection Fraction (HFrEF)
Implementation of an Encounter-based Patient Decision Aid for Heart Failure Medications in Heart Function Clinics: the SHARE-HF Pragmatic, Stepped-wedge Trial
The goal of this clinical trial is to learn if a shared decision-making tool called SHARE-HF can help more people with heart failure receive guideline-recommended medications.
- Trial name
- SHARE-HF (NCT07670845)
- Testing
- SHARE-HF decision aid
- Volunteers
- 1,350 people
- Sponsor
- University of British Columbia
Cancer
Quality Improvement Pilot
The overall goal of this study is to develop and pilot test the use of practice facilitation as an intervention for healthcare providers and staff, with the goal of improving the implementation of cancer prevention and screening…
- Trial name
- NCT05415800
- Testing
- Quality Improvement Practice Facilitation Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Older Hospitalized Patients
Geriatric Telemanagement of HEALTH Conditions in Nursing Home Residents Recently Discharged From the Hospital- GET HEALTH-I
Get-HEALTH-I study is a retrospective prospective interventional study to evaluate the impact of a geriatric telemanagement program on cost-effectiveness and clinical outcomes in nursing home residents post-hospital discharge.
- Trial name
- GET-HEALTH-I (NCT06893419)
- Testing
- Geriatric telemanagement
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
ICU Patients, Surgical
Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs
The goal of this interventional clinical trial is to evaluate whether the implementation of an evidence-based, context-adapted clinical nutrition practice guideline can improve clinical nutrition management in surgical intensive…
- Conditions
- ICU Patients, Surgical, Nutrition Intervention, Enteral Nutrition
- Trial name
- NCT07337798
- Testing
- Guideline Implementation
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Respiratory Infection, Influenza-like Illness
Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care
The ImpProGUIDE study aims to find out whether implementing new Swiss national guidelines for acute respiratory infections (ARI) can help to reduce antibiotic prescribing in primary care.
- Trial name
- ImpProGUIDE (NCT07396428)
- Testing
- Training Session on acute respiratory infection guideline within a multifaceted implementation strategy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
HFrEF - Heart Failure With Reduced Ejection Fraction, Guideline Adherence
Guideline Implementation and Quality of Care Evaluation in Patients With Heart Failure and Reduced Ejection Fraction (HFrEF)
The IMPLEMENT HF study is part of the national heart failure quality of care registry (evaluation of given health care). Within the HF registry, the investigators will investigate whether mirror information on the actual 4…
- Trial name
- IMPLEMENT HF (NCT07702760)
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Jasper Brugts MD PhD
Heart Failure, Heart Failure, Systolic
Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure
Many Veterans who are hospitalized with heart failure do not receive all the recommended heart medications at the right doses before they leave the hospital or in the weeks following discharge.
- Trial name
- PATRIOT-HF (NCT07714239)
- Testing
- Pharmacist/Cardiologist Virtual Team Digital Consultation
- Where
- United States
- Volunteers
- 585 people
- Sponsor
- VA Office of Research and Development
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Valve Disease, Heart, Gender Bias
Valvular Heart Disease in Women Registry
Valvular heart disease (VHD) is a major global health issue. Untreated rheumatic heart disease persists in many regions, preventable with timely care.
- Conditions
- Valve Disease, Heart, Gender Bias, Guideline Adherence, Guideline Implementation
- Trial name
- VHD-W (NCT07196930)
- Where
- 2 sites in Egypt, Portugal
- Volunteers
- 800 people
- Sponsor
- Valvular Heart Disease in Women Registry