Clinical trials: Gut Microbiomes
Gut Health, Microbiome
A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health
This study will evaluate the effects of the Artah Essential Fibre+ supplement on the microbiome and gut health over an 8-week period.
- Conditions
- Gut Health, Microbiome, Bloating, Indigestion
- Trial name
- NCT07781488
- Testing
- Essential Fibre+
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Artah Nutrition Limited
Gut Microbiome, Immune Responses
Effects of Probiotic Supplementation on Gut Health, Immune Response, and Well-Being
This randomized, double-blind, placebo-controlled exploratory study will evaluate the effects of daily probiotic supplementation on gut barrier function, immune-related markers, and well-being in healthy adults with mild to…
- Conditions
- Gut Microbiome, Immune Responses, Well-being
- Trial name
- NCT07779265
- Testing
- Probiotic capsules
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Orthomol Pharmazeutische Vertiebs GmbH
Kidney Transplant Symptoms, Gut Microbiome
The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation
Study Summary Nearly half (47%) of people with end-stage kidney disease (ESKD) whose kidney function is restored after kidney transplantation experience chronic pain compared to 19% of adults in the US general population.
- Trial name
- BIOME-KT (NCT06206486)
- Testing
- no intervention, observational
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Illinois at Chicago
Non-Small Cell Carcinoma of Lung, Gut Microbiomes
Microbiota in Neoadjuvant Chemoimmunotherapy for NSCLC
Locally advanced lung cancer (LALC) has poor prognosis despite multimodal therapies. Neoadjuvant chemoimmunotherapy is now standard for resectable stage II-IIIB NSCLC, but patient responses vary.
- Conditions
- Non-Small Cell Carcinoma of Lung, Gut Microbiomes, Neoadjuvant Chemoimmunotherapy
- Trial name
- NCT07752589
- Testing
- Neoadjuvant chemoimmunotherapy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Cognition, Gut Microbiome
The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study
This project uses a hybrid trial design to evaluate two biomedical interventions targeting the gut-brain axis. One intervention is portable Transcutaneous Vagus Nerve Stimulator, tVNS, that is hypothesized to stimulate the…
- Trial name
- NCT05090267
- Testing
- Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Florida
Dengue, Dengue Hemorrhagic Fever
Gut Leakage' in Dengue
Dengue infections are imposing an increasing global burden of disease, particularly in tropical countries such as Bangladesh. The World Health Organization (WHO) has identified Dengue virus as a priority pathogen for the…
- Conditions
- Dengue, Dengue Hemorrhagic Fever, Intestinal Disease, Ascites
- Trial name
- GLiD (NCT07602920)
- Where
- Bangladesh
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Adult Participants, Gut Microbiomes
DORA - A Study Using Digital Health Tools/Platform to Explore the Impact of the Consumption of Senior Milk Powder Containing Synbiotics on the Gut micRobiome in Healthy Aging Individuals
The DORA study is a single-arm, open-label, interventional exploratory study designed to evaluate the impact of a synbiotic-containing senior milk powder on the gut microbiome and selected biological, physiological, and digital…
- Conditions
- Healthy Adult Participants, Gut Microbiomes, AI
- Trial name
- DORA (NCT07575529)
- Testing
- Synbiotic Nutritional Product
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Gut Microbiome
Nutrition, Gut Microbiota and Health : Feces Sample Collection in NutriNet-Santé Participants
The gut microbiota is currently attracting increasing attention from the scientific community and also from the general public, as evidence of its role in human physiology has been highlighted.
- Trial name
- NUTRIGUT (NCT06941090)
- Testing
- sampling stool
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Postmenopausal Osteoporosis, Gut Microbiome
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
- Conditions
- Postmenopausal Osteoporosis, Gut Microbiome, Menopause
- Trial name
- NCT07365514
- Testing
- Blackcurrant (BC) extract
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Gut Microbiome, Gut Health
Understanding the Efficacy of Dietary Supplement on Fungal Mycobiota in Healthy Volunteers: A Pilot Study
The purpose of this study is to explore how the dietary supplement L-Phenylalanine affects the production of the metabolite phenylpropionic acid (PPA) and changes fungal populations of the gut microbiome.
- Conditions
- Gut Microbiome, Gut Health, Dietary Supplement, L-Phenylalanine
- Trial name
- NCT06433310
- Testing
- L-Phenylalanine 500 mg Veg Capsule product
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Transgender, Gut Microbiome
Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach
The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors.
- Conditions
- Transgender, Gut Microbiome, Immune System, Cardiovascular Risk Factors
- Trial name
- XCVD (NCT05334888)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Menopause, Gut Microbiome
AGEWISE: Unravelling the Gut-Hormone Axis in Women's Ageing
AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause.
- Conditions
- Menopause, Gut Microbiome, Hormonal Changes, Chronic Low-Grade Inflammation
- Trial name
- NCT07614542
- Where
- Portugal
- Volunteers
- 300 people
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Biomarkers of B-vitamin Status and Gut Microbiome Composition
Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)
Ageing is associated with changes in gut microbiota composition, increased inflammation, and a greater risk of poor mental health outcomes.
- Trial name
- NCT07592975
- Testing
- Inulin and B-vitamins, Inulin
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Gut Microbiome
Developing Interventions for Protecting HIV-Exposed Uninfected Infants Against Severe Infections
Research has shown that babies who are exposed to HIV, but are uninfected (negative HIV status), have a bigger risk of developing severe infections.
- Trial name
- NCT07052409
- Testing
- Inkomazi
- Where
- South Africa
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Breast Milk Collection, Human Milk/Breastfeeding
Human Milk and Its Effect on Infant's Metabolism and Infant Gut Microbiome
This protocol explains the MAINHEALTH cohort. The study examine the influence of maternal health parameters on human breast milk composition and integrates milk phenotype with infant metabolism and infant gut microbial content…
- Conditions
- Breast Milk Collection, Human Milk/Breastfeeding, Human Milk Microbiome, Infant Gut Microbiome
- Trial name
- MAINHEALTH (NCT05111990)
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Malnutrition (Calorie), Infant Nutrition Disorder
Goat Milk-Derived Formula vs. Undiluted Goat Milk in Infants Unable to Exclusively Breastfeed: Growth and Biomarker Analysis
The goal of this clinical trial is to learn if Goat Milk-Derived Formula Alternatives (GMDFA) are safe and effective for infants who are unable to be exclusively breastfed.
- Conditions
- Malnutrition (Calorie), Infant Nutrition Disorder, Growth Flatering, Gut Microbiome
- Trial name
- GMDFA (NCT07225153)
- Testing
- GMDFA, Undiluted Goat Milk
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Aga Khan University
Obesity & Overweight, Gut
Precision Nutrition Recommendations Generated by Metataxonomic Microbiome Testing Improve Food Group Choices and Intestinal Health Indicators in an Obese Population in Colombia
This study evaluated whether personalized dietary recommendations based on gut microbiome testing can improve intestinal health and food choices in adults with obesity in the region of Antioquia, Colombia.
- Conditions
- Obesity & Overweight, Gut, Microbiome
- Trial name
- NCT07492485
- Testing
- Personalized dietary recommendations
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Astrolab bio
Parkinson Disease, Diet, Healthy
Microbiome and Diet in Parkinson's Disease
The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia.
- Conditions
- Parkinson Disease, Diet, Healthy, Gut Microbiome, Gastrointestinal Microbiome
- Trial name
- PD-Diet (NCT06207136)
- Testing
- Mediterranean-style diet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Microbiome Dysbiosis, Gut Health
Colon-delivered Riboflavin and Gut Microbiota Composition
Recent studies suggest B-vitamins such as riboflavin to possess prebiotic-like effects. However, there is still a lack of understanding of the exact host health benefits vs. conventional systemically available vitamin forms.
- Trial name
- CONCOL (NCT07093463)
- Testing
- Colon-delivered riboflavin, Conventional riboflavin, Microcrystalline Cellulose
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet