Clinical trials: HFpEF - Heart Failure with Preserved Ejection Fraction
ANOCA - Angina With Non-obstructive Coronary Arteries, HFpEF - Heart Failure With Preserved Ejection Fraction
Peripheral Microvascular Blood Flow in ANOCA
An observational cross-sectional cohort study investigating whether peripheral endothelial function assessed using Laser speckle contrast analysis and coronary endothelial function measured with invasive coronary function testing…
- Trial name
- NCT05610410
- Testing
- Laser speckle contrast analysis
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Amsterdam UMC, location VUmc
Heart Failure With Preserved Ejection Fraction
PeRsonalIzed remOtely Guided Preventive exeRcIse Therapy for a healThY Heart
In the PRIORITY study, we aim to provide the clinical evidence base for the use of a new hybrid exercise intervention, which includes remotely guided home-based exercise, as an accessible, clinical and cost-effective treatment to…
- Trial name
- PRIORITY (NCT04745013)
- Testing
- PRIORITY, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Heart Failure With Preserved Ejection Fraction (HFPEF)
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases.
- Trial name
- SENSORFIT-4HEA (NCT07251361)
- Testing
- Supervised training
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Diabetes Mellitus, Type 2, Heart Failure With Preserved Ejection Fraction (HFPEF)
Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real-world data through large-scale emulation of randomized controlled trials.
- Trial name
- DUP-SUMMIT (NCT06914154)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 11,265 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Heart Failure With Preserved Ejection Fraction
Incidence and Echocardiographic Predictors of HFpEF in High-Risk Population Afferent to Italian Echo-labs Network
The evolving definitions of HF, the increasing attention of the medical community, and the aging of the population are some of the factors contributing to a still debated incidence and prevalence of HFpEF across the general and…
- Trial name
- rEPORt (NCT05753553)
- Where
- 6 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Failure With Normal Ejection Fraction
Exercise Intolerance in Heart Failure
The investigators are studying whether metabolic abnormalities in cardiac and skeletal muscle in patients with heart failure with preserved ejection fraction (HFpEF) are associated with debilitating exercise intolerance.
- Trial name
- NCT03775577
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Atrial Fibrillation (Paroxysmal), Hypertension
Renal Denervation in Patients With Atrial Fibrillation and Hypertension
High blood pressure is a major risk factor for atrial fibrillation (AF), an irregular heart rhythm, and heart failure with preserved ejection fraction (HFpEF), a condition in which the heart becomes stiff and cannot relax…
- Conditions
- Atrial Fibrillation (Paroxysmal), Hypertension, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- NCT07893821
- Testing
- Catheter-based renal artery electrical stimulation (as a feasibility assessment for renal denervation)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Pavel Antiperovitch
Heart Failure, Heart Failure With Preserved Ejection Fraction
Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE)
Acute heart failure (AHF) is defined as rapid onset or rapid worsening of typical signs and symptoms of heart failure (HF) according to the 2016 European Society of Cardiology Guidelines.
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- FUTURE-HIT (NCT05204238)
- Testing
- Transthoracic Echocardiography
- Where
- 31 sites in Australia, Belgium and 10 more
- Volunteers
- 998 people
- Sponsor
- University of Siena
Heart Failure with Preserved Ejection Fraction (HFPEF), Heart Failure with Reduced Ejection Fraction
Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Study
This study is designed to evaluate the safety, feasibility, and effectiveness of a 12-week eccentric exercise program for older adults with sarcopenia (muscle loss) or sarcopenic obesity and chronic heart failure (HF).
- Conditions
- Heart Failure with Preserved Ejection Fraction (HFPEF), Heart Failure with Reduced Ejection Fraction, Sarcopenia in Elderly, Sarcopenic Obesity
- Trial name
- ECLYPSE-HF (NCT06826963)
- Testing
- Aerobic eccentric intervention
- Where
- 2 sites in Italy
- Volunteers
- 15 people
- Sponsor
- Universita di Verona
Heart Failure With Preserved Ejection Fraction, Obesity, Mild
Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction
Study Aim is creation of the Hospital Register of patients with heart failure with preserved ejection fraction (HFpEF) for a comprehensive assessment of the influence of gender characteristics, clinical and anamnestic factors…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Obesity, Mild, Decompensated Heart Failure
- Trial name
- NCT06114498
- Testing
- Echocardiography, Bioimpedance, Immunoassay
- Where
- 2 sites in Russia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Heart Failure With Preserved Ejection Fraction
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition have recently been reported in two clinical trials.
- Trial name
- NCT05562063
- Testing
- Sotagliflozin
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Juan Badimon
Diastolic Heart Failure
Cardiac Resynchronisation Therapy Versus Rate-responsive Pacing in Heart Failure With Preserved Ejection Fraction
Half of patients with heart failure have normal heart pumping function (Heart failure with Preserved Ejection Fraction, HFpEF), most commonly characterised by breathlessness on exercise.
- Trial name
- PREFECTUS (NCT03338374)
- Testing
- Biventricular pacemaker
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Cardiff and Vale University Health Board
Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
TX000045-003 is a double-blind, randomized, parallel group, placebo-controlled, proof- of-concept (POC) study, evaluating 2 dose regimens of TX000045 over the course of a 24-week treatment period (the APEX study).
- Trial name
- NCT06616974
- Testing
- TX000045- Dose A, TX000045- Dose B
- Where
- 72 sites in United States, Armenia and 15 more
- Volunteers
- 191 people
- Sponsor
- Tectonic Therapeutic
Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction
Predictors and Outcomes of In-hospital HFpEF in AMI Patients
This retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (HFpEF) in patients with acute myocardial infarction(AMI).
- Conditions
- Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction, Predictor, Prognosis
- Trial name
- NCT03351179
- Testing
- clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangjun Yang
Heart Failure
Myocardial Performance at Rest and During Exercise in Heart Failure With Preserved Ejection Fraction
This study is being done to study how well the heart contracts and relaxes during exercise. In addition to traditional measures of heart function, we will use a new computer program that may improve understanding of why people…
- Trial name
- X-HF-SPECKLE (NCT01747785)
- Testing
- Cardiac rehabilitation, Myocardial deformation imaging, Cardiopulmonary exercise test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HFpEF - Heart Failure with Preserved Ejection Fraction, Atrial Fibrillation (AF)
Atrial Fibrillation with Heart Failure with Preserved Ejection Fraction: Treatment Strategies-Catheter Ablation Vs. Anti-Atrial Arrhythmia Drugs
A comparison of whether catheter ablation improves the prognosis (all-cause mortality and/or the composite endpoint of MACE) and reduces the recurrence rate of atrial fibrillation (AF) in patients with AF and heart failure with…
- Trial name
- NCT06740539
- Testing
- Catheter ablation of atrial fibrillation
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Shanghai Chest Hospital
Heart Failure With Preserved Ejection Fraction
Study to Evaluate the Efficacy and Safety of AZD4831 in Participants With Heart Failure With Left Ventricular Ejection Fraction > 40%
This is a randomised, double-blind, placebo-controlled, multi-center sequential phase 2b and Phase 3 study to evaluate the efficacy and safety of AZD4831 administered for up to 48 Weeks in participants with heart failure with…
- Trial name
- ENDEAVOR (NCT04986202)
- Testing
- AZD4831
- Where
- 171 sites in United States, Australia and 16 more
- Volunteers
- 711 people
- Sponsor
- AstraZeneca
Heart Failure With Preserved Ejection Fraction
A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
This is a study to evaluate whether macitentan is an effective and safe treatment for patients with heart failure with preserved ejection fraction (HFpEF) and pulmonary vascular disease.
- Trial name
- SERENADE (NCT03153111)
- Testing
- Macitentan
- Where
- 95 sites in United States, Argentina and 15 more
- Volunteers
- 143 people
- Sponsor
- Actelion
Atrial Fibrillation
Catheter Ablation for Atrial Fibrillation in Preserved Ejection Fraction
Atrial fibrillation (AF) displays high prevalence in heart failure with preserved ejection fraction (HF-PEF) and compromises prognosis of affected patients.
- Trial name
- AFFECT (NCT04317911)
- Testing
- Catheter Ablation
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Heidelberg
Heart Failure With Preserved Ejection Fraction (HFpEF)
A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers
This is an open-label, non-randomized, fixed sequence study conducted at a single study center with primary aim to assess the pharmacokinetics (PK) of AZD9977 in healthy volunteers when administered alone and in combination with…
- Trial name
- NCT03843060
- Testing
- AZD9977, Itraconazole
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca