Clinical trials: HIV/AIDS PREVENTION
Growth and Development
Infant Peri-Exposure Prophylaxis to Prevent HIV-1 Transmission by Breastfeeding: Mechanisms & Safety
General objective To assess the long-term safety and efficacy of one-year infant prophylaxis using lamivudine (3TC) or lopinavir/ritonavir (LPV/r) to prevent post-natal transmission through breastfeeding.
- Trial name
- NCT03519503
- Where
- 4 sites in Burkina Faso, South Africa and 2 more
- Volunteers
- 562 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Human Immunodeficiency Virus
A Combination HIV Prevention Strategy for Young Women at Risk for HIV
The purpose of this study is to conduct formative research to inform the design and implementation of combination prevention interventions, including pre-exposure prophylaxis (PrEP) for female sex workers (FSW), as well as to…
- Trial name
- IPrEP (NCT03235518)
- Where
- Kenya
- Volunteers
- 329 people
- Sponsor
- Columbia University
Prevention of Mother-to-child Transmission of HIV
Retention of Women in the PMTCT (Prevention of Mother-to-child Transmission of HIV)
EXECUTIVE SUMMARY RESEARCH QUESTION TO BE ADDRESSED BY THIS PROPOSAL What are the factors associated with retention-in-care of women enrolled in the eMTCT Option B+ program at eMTCT (elimination of mother-to-child transmission of…
- Trial name
- NCT03213223
- Where
- Zimbabwe
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
HIV Prevention, STI Prevention
Formative Research for an HIV Videogame for Young Black Women
As part of Yale's Play2Prevent (www.Play2Prevent.org) program to develop videogame-based interventions targeting risk reduction and prevention in youth and young adults, this study is designed to develop a paper prototype and…
- Trial name
- NCT02685410
- Testing
- One Night Stan Prototype
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Anti-Infective Agents, Anti-Retroviral Agents
Safety, PK, and PD Study of IVRs Releasing TFV and LNG
This multi-center Phase I study is designed to characterize the safety, PK, and PD of TFV/LNG IVR to assess systemic and genital tract bioavailability in healthy women.
- Conditions
- Anti-Infective Agents, Anti-Retroviral Agents, Contraceptive Usage
- Trial name
- TFV/LNG IVR (NCT03279120)
- Testing
- TFV/LNG IVR
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- CONRAD
HIV Prevention
Dat'Aids Prevention
DatAIDS prevention is a cohort study of HIV prevention in over 23 HIV sites in France including overseas, aiming to describe HIV prevention in every aspect including HIV screening, STI and hepatitis screening, post-exposure…
- Trial name
- NCT03795376
- Where
- 31 sites in France, Guadeloupe and 1 more
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- DatAids
HIV Prevention
Mobile Vehicle-Based Delivery of Lenacapavir Pre-Exposure Prophylaxis in Los Angeles County
This project evaluates the implementation strategy of the delivery of lenacapavir pre-exposure prophylaxis (LEN PrEP) - a newly available long-acting, injectable medication for human immunodeficiency virus (HIV) prevention - via…
- Trial name
- MOVE-LA (NCT07467018)
- Testing
- Community-based healthcare delivery, Lenacapavir
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
HIV, Risk Reduction Behavior
A Digital Intervention for HIV Prevention in Black Adolescent Girls
The purpose of this study is to develop and evaluate an innovative behavioral HIV prevention videogame intervention to bolster motivation and provide skill-building opportunities to improve Black adolescent girls' ability to…
- Trial name
- NCT04108988
- Testing
- InvestiDate, Non-Health Related Video Game
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Yale University
Exposure to Human Immunodeficiency Virus (Event)
What Happens in Vegas: PEP to PrEP Opportunities
Observational study looking at barriers to care for individuals seeking care, Post Exposure Prophylaxis (PEP) after an actual or perceived exposure to HIV.
- Trial name
- NCT03775083
- Testing
- Currently approved medications
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Huntridge Family Clinic
HIV Infections, Sexually Transmitted Diseases
HIV and STD Prevention for High-Risk, Inner-City, African American Youth
This study will evaluate the joint and separate effectiveness of two HIV/STD prevention programs in providing protection against acquiring STDs and maintaining safer sex behavior.
- Trial name
- NCT00353405
- Testing
- Social Skills Training, Mass media, Control
- Where
- 4 sites in United States
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tuberculosis
Ultra Curto (Ultra Short) TB Prevention Therapy
To compare treatment success (adherence and completion of treatment) and safety of 1HP with 3HP in HIV-uninfected adults and adolescents at increased risk of TB.
- Trial name
- NCT04703075
- Testing
- Rifapentine 600 mg and INH 300 mg, Rifapentine 900 mg and INH 900 mg
- Where
- 2 sites in Brazil
- Volunteers
- 531 people
- Sponsor
- Johns Hopkins University
Cervical Neoplasia, Cervical Cancer
Cervical Cancer Screening in HIV Positive and Negative Women in Cambodia
The prevalence of cervical neoplasia in Cambodia is not known. There are no screening programs in place. The investigators plan on introducing a screening program based on WHO criteria and utilizing visualization with acetic…
- Trial name
- NCT02253719
- Testing
- cryotherapy, further biopsy, LEEP, surgery as indicated
- Where
- Cambodia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sihanouk Hospital Center of HOPE
Improving Perceptions of HIV Risk, Improving Uptake of Pre-exposure Prophylaxis for HIV
Manicaland PrEP Uptake Through Interactive Counselling Trial
Primary Objective: The purpose of this trial is to evaluate the impact of an interactive tablet based counselling session correcting risk perception and addressing ambiguity around availability, usability and effectiveness of…
- Trial name
- NCT03565575
- Testing
- Interactive tablet-based quiz
- Where
- 8 sites in Zimbabwe
- Volunteers
- 1,055 people, healthy volunteers welcome
- Sponsor
- Simon Gregson
Hiv
Mhealth for PrEP Adherence by Young Adult MSM, Phase 2
This Phase 2 project aims to enhance and test a mobile health intervention designed to increase adherence to the daily PrEP pill among culturally-diverse young adult men who have sex with men.
- Trial name
- NCT04633200
- Testing
- DOT mobile app
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Environment and Health Group, Inc.
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sexual Risk, Substance Use
An Innovative HIV Prevention Intervention Using Social Networking Technology
An existing face-to-face HIV prevention intervention (The Young Men's Health Project, YMHP; R01DA20366) will be iteratively adapted and pilot-tested to target difficult to engage high-risk young men who have sex with men (YMSM)…
- Trial name
- NCT01381653
- Testing
- Behavioral: HIV prevention intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
HIV Infections
ADAPT-POL New Orleans: Adaptation of Prevention Techniques With Popular Opinion Leader
Adopting and Demonstrating the Adaptation of Prevention Techniques (ADAPT) is a supplement to the Centers for Disease Control and Prevention (CDC) Community Based Organization Program Announcement 04064 (PA 04064).
- Trial name
- NCT00252109
- Testing
- Popular Opinion Leader
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV, Pregnancy
Evaluating HITSystem 2.1 to Improve Viral Suppression in Kenya
The goal of this project is to rigorously evaluate the efficacy of HIV Infant Tracking System 2.1 (HITSystem, an eHealth intervention that uses short message service (SMS) texts to patients and algorithm-driven electronic alerts…
- Trial name
- NCT04571684
- Testing
- HITSystem 2.1
- Where
- 12 sites in Kenya
- Volunteers
- 1,639 people
- Sponsor
- University of Kansas Medical Center
Health Behavior, Risky, Health Knowledge, Attitudes, Practice
Sistas Informing Sistas on Topics About AIDS and Prevention (SISTA-P)
In this project, the investigators will provide a new HIV prevention training and empowerment sessions to Black women in Washington D.C., Atlanta and New Orleans, who are at high risk for getting HIV.
- Conditions
- Health Behavior, Risky, Health Knowledge, Attitudes, Practice, Health-Related Behavior
- Trial name
- SISTA-P (NCT06307028)
- Testing
- SISTA-P Intervention
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Tuberculosis Infection, Tuberculosis Prevention
Qualitative Understanding of Community TB Services Pre and Post the CHIP-TB Trial
This qualitative study is designed to elicit the perspectives of relevant stakeholders to adapt a community-based TB/HIV intervention aimed on providing home-based TB prevention treatment (TPT) initiation for child TB contacts…
- Trial name
- NCT04494516
- Where
- 2 sites in Ethiopia, South Africa
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University