Clinical trials: HIV Infections, completed
HIV Infections
Study of Darunavir/r + Tenofovir/Emtricitabine vs. Darunavir/r + Raltegravir in HIV-infected Antiretroviral naïve Subjects
The triple therapy darunavir/r + tenofovir/emtricitabine is likely to become a relevant first-line treatment option in the years to come.
- Trial name
- ANRS 143 (NCT01066962)
- Testing
- darunavir/ritonavir QD + raltegravir BID, darunavir/r QD + tenofovir/emtricitabine QD (fixed dose combination)
- Where
- 77 sites in Austria, Belgium and 13 more
- Volunteers
- 800 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
Traditional Complementary and Alternative Medicine (CAM) Therapy in the Treatment of HIV/AIDS
This research work is important for the cure/control of HIV infection. The study is intended to confirm the efficacy of "Kallunk Oxide (Immunotherapy)" molecules in the Treatment of HIV infection.
- Trial name
- NCT01349062
- Testing
- "Kallunk oxide (Immunotherapy) "
- Where
- 3 sites in India
- Volunteers
- 1,000 people
- Sponsor
- Traditional Alternative Medicine Research, India
HIV
Imaging the HIV Reservoir
Radiolabelling broadly neutralizing anti-HIV antibody 3BNC117 with a Copper-64 radio isotope for infusion into people with HIV followed by MRI/PET scanning to detect HIV in vivo.
- Trial name
- NCT03063788
- Testing
- 3BNC117-Copper-64
- Where
- Australia
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bayside Health
HIV Prevention, PrEP
Using Smart Phone Technology to Support PrEP Uptake and Adherence
This is a single arm pilot study of a new smartphone app to support adherence to PrEP medication for HIV prevention in public clinics in Virginia.
- Conditions
- HIV Prevention, PrEP, Adherence, Medication
- Trial name
- prep'd (NCT04868383)
- Testing
- Use of smart phone technology to support medication adherence and uptake
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Virginia
Hypogonadism, HIV
Study of the Prevalence and Associated Factors With Hypogonadism in HIV + Men
Testosterone deficiency is classically associated with the development of metabolic syndrome, osteoporosis, erectile disorder and / or a reduced libido, a depressive syndrome and alteration of the quality of patients life.
- Trial name
- HYPOG (NCT02665559)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Tourcoing Hospital
Tuberculosis, Tuberculous Meningitis
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis
The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment…
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury
- Trial name
- NCT03100786
- Testing
- Dexamethasone
- Where
- 3 sites in Vietnam
- Volunteers
- 702 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Depression
Healthy Options: Group Psychotherapy for HIV-positive Depressed Perinatal Women.
Although there is a significant burden of depression among HIV-positive women in Tanzania, there is a critical gap between the needs of this population and the integration of mental health and PMTCT-plus services.
- Trial name
- NCT02039973
- Testing
- Task-sharing approach to group therapy, Enhanced standard of care
- Where
- Tanzania
- Volunteers
- 742 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
HiV1- Positive
Nucleoside Switch Pilot for Virologically Controlled HIV Subjects With Decreasing CD4 Cells Who Have Received TDF-based ARV Therapy
The purpose of this study is to assess the safety, tolerability, and antivira activity of Epzicom in virologically controlled HIV subjects.
- Trial name
- EPZSwitch (NCT01608269)
- Testing
- Abacavir/Lamivudine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Therapeutic Concepts
HIV Infections
A "Pre-Enrollment" Protocol for HIV-Infected Adolescents
PRIMARY: To identify, characterize, and co-enroll HIV-infected adolescents into existing and future ACTG (or other NIH-sponsored) HIV treatment protocols through the systematic and recurrent assessment of eligibility.
- Trial name
- NCT00000780
- Where
- 51 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer, Human Papillomavirus Infection
Long Term Follow-up of HPV Vaccine in HIV (CTN 236)
The purpose of this extension study is to determine whether HPV antibody levels in HIV-positive girls and women will decline more rapidly and more significantly than in HIV-negative girls and women and if this decline is…
- Conditions
- Cervical Cancer, Human Papillomavirus Infection, Human Immunodeficiency Virus, Cervical Dysplasia
- Trial name
- NCT06915779
- Where
- 13 sites in Canada
- Volunteers
- 241 people
- Sponsor
- University of British Columbia
HIV, Pregnancy
A Study to Evaluate the Effects of Genetic Factors on the Pharmacokinetics of Antiretroviral Drugs During Pregnancy and Lactation
Mother-to-child transmission of HIV (MTCT) during pregnancy and breastfeeding is prevented with maternal antiretroviral drugs (ARV) and infant nevirapine post-exposure prophylaxis (PEP).
- Conditions
- HIV, Pregnancy, Breastfeeding
- Trial name
- NCT02269462
- Testing
- Efavirenz, Nevirapine
- Where
- 3 sites in Nigeria
- Volunteers
- 460 people
- Sponsor
- Adeniyi Olagunju
Hypertension, HIV
iHEART-SA Intervention Study
Using qualitative data during the formative phase the IHEART-SA research study filled deficiencies in knowledge regarding: 1) what barriers exist to integrating hypertension care within the HIV care setting in South Africa and…
- Trial name
- iHEART-SA (NCT05846503)
- Testing
- 1. Quality and info management system
- Where
- South Africa
- Volunteers
- 4,378 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
HIV/AIDS
The CHAPS Trial: Combined HIV Adolescent PrEP and Prevention
To compare the effect of different PrEP drugs (FTC-TDF and FTC-TAF), doses and timing of doses on p24 antigen level in resected foreskin tissue following HIV exposure ex vivo challenge.
- Trial name
- CHAPS (NCT03986970)
- Testing
- Tenofovir
- Where
- South Africa
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wits Health Consortium (Pty) Ltd
HIV Infections, Hepatitis C
Treatment of Hepatitis C in Hemophilic Patients With HIV
Pegylated interferon (PEG-interferon) and ribavirin are accepted treatments for hepatitis C virus (HCV) infection. However, HCV infection progresses differently in patients who are coinfected with HIV and in hemophiliacs.
- Conditions
- HIV Infections, Hepatitis C, Hemophilia
- Trial name
- NCT00055341
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acquired Immunodeficiency Syndrome, Heart Diseases
AIDS-Associated Cardiomyopathy
To define the incidence and prevalence of AIDS-associated cardiomyopathy. Also, to conduct immunopathology and serologic studies in endomyocardial biopsies and autopsy tissues.
- Conditions
- Acquired Immunodeficiency Syndrome, Heart Diseases, Myocardial Diseases, HIV Infections
- Trial name
- NCT00005227
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Human Immunodeficiency Virus
Mobile-health (mHealth) Intervention to Support HIV Self-testing and PrEP Uptake Among Young Men Who Have Sex With Men
The proposed study will involve adolescent (17-24 years old) men who have sex with men (described as YMSM hereafter) who meet eligibility criteria to participate.
- Trial name
- NCT04865341
- Testing
- IMB, Information-Only Control
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Human Immunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS)
Enhanced Prevention in Couples: Feasibility Study #2
The purpose of this study is to gather information needed to develop a large prevention trial to decrease risk for Human immunodeficiency virus (HIV) transmission among HIV-discordant couples (where one person is HIV-positive and…
- Trial name
- EPIC (NCT02027441)
- Testing
- Standard Counseling and Testing
- Where
- 2 sites in Lesotho
- Volunteers
- 191 people
- Sponsor
- Columbia University
HIV/AIDS
Positive Affect Promotion to Empower Optimal Adherence to HIV Therapy
This study assesses the feasibility and acceptability of the APPEAL program, a 3-session intervention designed to promote positive affect among men and women living with HIV infection.
- Trial name
- NCT04035759
- Testing
- APPEAL
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- State University of New York - Downstate Medical Center
HIV-1 Infection
Evaluation of Safety, Tolerability, Pharmacokinetics, and Antiretroviral Activity of Ulonivirine (MK-8507) in Human Immunodeficiency Virus (HIV-1)-Infected Participants (MK-8507-003)
The study will evaluate the safety, tolerability, pharmacokinetics, and antiretroviral activity of a single dose of ulonivirine in antiretroviral therapy (ART)-naive, HIV-1 infected participants.
- Trial name
- NCT02174159
- Testing
- Ulonivirine
- Volunteers
- 18 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Comparison of ddI Versus Zidovudine in HIV-Infected Patients
To compare the effectiveness and toxicity of didanosine (ddI) and zidovudine (AZT) in patients with AIDS, advanced AIDS-related complex (ARC), or asymptomatic infection with CD4 counts < 200 cells/mm3.
- Trial name
- NCT00000979
- Testing
- Zidovudine, Didanosine
- Where
- 71 sites in United States, Puerto Rico
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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