Clinical trials: HSCT
Sickle Cell Disease, Thalassemia
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
Background: Some sickle cell disease or beta-thalassemia can be cured with transplant. Researchers want to test a variation of transplant that uses low dose radiation and a combination of immunosuppressive drugs.
- Conditions
- Sickle Cell Disease, Thalassemia, Stem Cell Transplantation, Graft vs Host Disease
- Trial name
- NCT02105766
- Testing
- Alemtuzumab, Sirolimus, Cyclophosphamide
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hematologic Malignancy
TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies
This is a phase I, prospective clinical trial studying the safety and feasibility of providing early memory T-cell DLI. The primary objective is: To assess the safety and feasibility of early CD45RA-depleted DLI administration.
- Trial name
- NCT07052370
- Testing
- Thymoglobulin, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Anxiety Disorder, Depression
Nursing Intervention in Supporting Family Caregivers of Patients Undergoing Stem Cell Transplant
This randomized clinical trial studies nursing intervention in supporting family caregivers (FCs) of patients undergoing stem cell transplant. A nursing intervention may help prepare FCs support the recovery of the patients
- Conditions
- Anxiety Disorder, Depression, Fatigue
- Trial name
- NCT01341873
- Testing
- educational intervention, psychosocial support for caregiver, quality-of-life assessment
- Volunteers
- healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Lymphoma, Leukemia
Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation
RATIONALE: Following stem cell transplantation, a major risk is graft-versus-host disease (GVHD). This occurs when donor immune cells that have been infused recognise the host's cells as 'foreign' and attack these cells.
- Conditions
- Lymphoma, Leukemia, Myeloma, Myelodysplastic Syndromes
- Trial name
- ToTem (NCT03836690)
- Testing
- CD62L- Tem
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University College, London
Malignant Lymphoma, Stem Cell Type
Healthy Donor Study II - Comparing Plerixafor With G-CSF and Plerixafor
Stem cells can be transplanted from a healthy donor to a patient to combat blood cancers and other disorders. This process is called stem cell transplantation. Stem cells normally live in the bone marrow.
- Trial name
- NCT01403896
- Testing
- Plerixafor (Mozobil), Plerixafor + G-CSF
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stephen Couban
Hematologic Malignancy
Cancer and Immune Cell Metabolism in Patients With Hematological Malignancies
This study investigates how metabolism in cancer and immune cells shapes the bone marrow environment, influences therapy resistance, and affects outcomes in hematological malignancies.
- Trial name
- NCT07189117
- Where
- Switzerland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Opportunistic Fungal Infection, Opportunistic Viral Infection
T Lymphocytes for the Treatment of AdV, CMV, EBV, BKV and Aspergillus Fumigatus Infections After Allogeneic Stem Cell Transplantation
The purpose of the study is to determine the feasibility, safety and efficacy of administering rapidly-generated donor-derived pentavalent-specific T cells (Penta-STs) to mediate antiviral and antifungal activity in hematopoietic…
- Conditions
- Opportunistic Fungal Infection, Opportunistic Viral Infection, Bone Marrow Transplant Infection
- Trial name
- Penta-STs-001 (NCT05471661)
- Testing
- Pentavalent-specific T cells (penta-STs)
- Where
- 2 sites in Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- George Papanicolaou Hospital
Inflammatory Bowel Diseases, Microbiota
Microbiome Alterations in IL10RA-deficient Patients After HSCT
To elucidate the longitudinal development of intestinal microbiota in patients with IL10RA deficiency after hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT03752372
- Testing
- hematopoietic stem cell transplantation
- Where
- China
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
AML (Acute Myeloid Leukemia), MDS/AML
Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation
Safety and Feasibility of a Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation in AML, MDS/AML and Higher Risk MDS
- Conditions
- AML (Acute Myeloid Leukemia), MDS/AML, MDS (Myelodysplastic Syndrome)
- Trial name
- NCT07214064
- Testing
- RIC regimen
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Graft-versus-host Disease, Poor Graft Function
Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function
The present project aims at investigating the role of MSC for the treatment of patients with Part 1: Steroid-refractory grade II-IV acute GVHD.
- Conditions
- Graft-versus-host Disease, Poor Graft Function, Low Donor T-cell Chimerism
- Trial name
- NCT00603330
- Testing
- Mesenchymal stem cells
- Where
- 12 sites in Belgium, Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege
cGVHD
Safety and Efficacy of Iguratimod in the Treatment of Chronic GVHD
This is a randomized, single-center phase 1/2 clinical trial without blinding. Iguratimod, as a rheumatoid arthritis medication, is used to treat autoimmune diseases such as Sjögren's syndrome.
- Trial name
- NCT06244628
- Testing
- Iguratimod
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation
This phase II trial studies how well 3 different drug combinations prevent graft versus host disease (GVHD) after donor stem cell transplant.
- Conditions
- Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Trial name
- NCT03602898
- Testing
- Anti-Thymocyte Globulin, Busulfan, Cyclophosphamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Myeloma
Maintenance Therapy Using Lenalidomide in Myeloma
Maintenance treatment of myeloma.
- Trial name
- IFM2005-02 (NCT00430365)
- Testing
- lenalidomide
- Where
- 77 sites in Belgium, France and 1 more
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy
The purpose of this study is to learn about possible changes in brain anatomy and in thinking abilities, such as memory skills, in patients with cancer who receive treatment with chemotherapy alone or in combination with total…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Acute Undifferentiated Leukemia, Biphenotypic Leukemia
- Trial name
- NCT00606216
- Testing
- MRI and cognitive evaluation, brain MRI study and a brief neuropsychological evaluation
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML
This study will evaluate combining stem cells from the patient's matched sibling donor (a standard CD34-selected transplant) with a second infusion of white blood cells called "CD8 memory T-cells" from their sibling donor.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Acute Leukemia
- Trial name
- NCT04151706
- Testing
- CD8+ Memory T Cell Infusion, Thiotepa, Fludarabine
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Robert Lowsky
Blood And Marrow Transplantation
Plerixafor for Stem Cell Mobilization in Normal Donors
The goal of this clinical research study is to learn if treating stem cell donors with filgrastim (G-CSF) and plerixafor (Mozobil®) can cause them to produce a higher number of blood stem cells than filgrastim by itself.
- Trial name
- NCT01818284
- Testing
- Filgrastim, Plerixafor, Apheresis Procedure
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Neoplasms
CAREgiver Study for Patients Undergoing HSCT
The investigators will use a single arm design and deliver a new supportive intervention entitled, "Ready to Connect, Actively Relax and Exercise (CARE)." The purpose of the study is to describe the feasibility, acceptability…
- Trial name
- NCT03210727
- Testing
- Ready to CARE program
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Thrombocytopenia, Isolated, Stem Cell Transplant Complications
AZA Combined With NAC for PIT After HSCT
Prolonged isolated thrombocytopenia (PIT) that is refractory to conventional treatments has remained a critical complication after allogeneic hematopoietic cell transplantation since decades years ago.
- Trial name
- NCT05126004
- Testing
- Azacitidine, N Acetyl L Cysteine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Graft Versus Host Disease in Eye, Ocular Complications
Ocular Complications From Cancer Therapy - Patient Registry and Biobank
The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and…
- Conditions
- Graft Versus Host Disease in Eye, Ocular Complications, Inflammatory Dry Eye Disease
- Trial name
- NCT06874283
- Testing
- Eye exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Non Hodgkin Lymphoma, Hodgkin Lymphoma
Thiotepa-based Conditioning for Allogeneic Stem-cell Transplantation (SCT) in Lymphoid Malignancies
The study hypotheses is that the introduction of dose escalated thiotepa, in substitution to busulfan or melphalan, will reduce toxicity after allogeneic transplantation while improving disease eradication in patients with…
- Conditions
- Non Hodgkin Lymphoma, Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Multiple Myeloma
- Trial name
- NCT02507479
- Testing
- Thiotepa
- Where
- 2 sites in Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center