Clinical trials: HV
Healthy, Obesity
New Heart Imaging Techniques to Evaluate Possible Heart Disease
Background: Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness.
- Conditions
- Healthy, Obesity, Diabetes, Healthy Volunteers
- Trial name
- NCT01399385
- Testing
- MR Imaging Techniques - 1, MR Imaging Techniques - 2, MR Imaging Techniques - 3
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Adolescent, Healthy Volunteers (HV)
Effects of Integrative Neuromuscular Traning on Physical Fitness and Dribbling Performance Among High School Male Football Players in Shandong, China
This study investigates the effects of a 12-week Integrative Neuromuscular Training (INT) program on physical fitness, balance, and dribbling skills in male high school soccer players in Shandong, China.
- Conditions
- Adolescent, Healthy Volunteers (HV), Physical Fitness and Technical Skills, Football Players
- Trial name
- NCT07017049
- Testing
- Integrative Neuromuscular Training, Routine training intervention
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xinrui Zhang
Epilepsy, Epilepsy, Temporal Lobe
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression
Objective: To study the relative balance of GABA (A) binding potential and glutamate utilization in subjects with localization-related epilepsy with and without depression, subjects with major depressive disorder alone, and in…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Depression, Depressive Disorder, Major
- Trial name
- NCT00931619
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
SARS Virus
Investigating Severe Acute Respiratory Syndrome (SARS)
Severe Acute Respiratory Syndrome (SARS) is a newly recognized illness that can be fatal. The purpose of this study is to better understand SARS by collecting samples of blood and other body fluids of people who have been exposed…
- Trial name
- NCT00066209
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obsessive-Compulsive Disorder
Characterization of Childhood-Onset Obsessive-Compulsive Disorder
The purpose of this study is to learn more about Obsessive-compulsive Disorder (OCD) in children. OCD usually has a slow onset, and symptoms that may remain at a stable level over time.
- Trial name
- NCT00044239
- Where
- 4 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Covid19
Phase 1 Study to Assess Safety, Tolerability, PD, PK, Immunogenicity of IV NTR-441 Solution in Healthy Volunteers and COVID-19 Patients
This first-in-human clinical study is a Phase 1a/ 1b, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and PK/PD of NTR-441 in healthy subjects and patients with COVID-19 after single…
- Trial name
- NCT04941183
- Testing
- NTR-441
- Where
- 4 sites in Austria, Ukraine
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Neutrolis
Glucose Homeostasis, Protein Metabolism
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Background: Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress.
- Conditions
- Glucose Homeostasis, Protein Metabolism, Lipid Metabolism, Respiratory Function
- Trial name
- NCT01143493
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Functional Movement Disorders
Brain Activity in People With Functional Movement Disorders
This study will use functional MRI (fMRI, a technique that shows what areas of the brain are active when performing different mental tasks), to examine how the brain in people with functional movement disorders (FMD) may differ…
- Trial name
- NCT00448084
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Imaging of CB1 Receptors Using (11C)SD5024
Background: The cannabinoid type 1 (CB1) receptor is a protein found on some brain cells. It may play a role in obesity or some psychiatric disorders such as schizophrenia.
- Trial name
- NCT01399398
- Testing
- Brain Scan-PET, Brain Scan-MRI, Arterial Line
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Placebo Analgesia
Oxytocin and Arginine Vasopressin in Pain Relief
Background: Oxytocin, a substance produced mostly in the brain, plays a role in influencing social interactions and reactions to stress, and may be related to pain.
- Trial name
- NCT01328561
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, NAFLD
DDI Study of ASC41 in HV and the PK, Safety and Tolerability in Subjects With NAFLD.
The primary objective of this study is to evaluate the effect of itraconazole, a strong inhibitor)of cytochrome P4503A , and phenytoin a strong inducer of cytochrome P450 3A, CYP3A4, CYP1A2 and CYP2C19 on the pharmacokinetics of…
- Trial name
- NCT04845646
- Testing
- ASC41, Itraconazole, Phenytoin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gannex Pharma Co., Ltd.
Hemorrhagic Fever, Ebola, Healthy
Experimental Ebola Vaccine Trial
This study will test the safety of an experimental vaccine developed to protect against Ebola virus infection and to determine if the vaccine induces an immune response to the virus.
- Trial name
- NCT00072605
- Testing
- VRC-EBODNA012-00-VP
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Candidate HIV Vaccine
This study will evaluate whether an experimental vaccine intended to prevent HIV infection is safe and whether it causes any side effects.
- Trial name
- NCT00089531
- Testing
- VRC-HIVDNA016-00-VP
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stroke
Moving a Paralyzed Hand Through Use of a Brain-Computer Interface
This study will gain information on methods of control of a prosthetic arm in stroke patients or traumatic brain inury patients through a technique called "brain-computer interface" (BCI).
- Trial name
- NCT00242242
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Adult Participants, Diabetic Kidney Disease
Evaluation of MTX-439 in Healthy Adults and Adults With Diabetic Kidney Disease
This is a phase 1 randomized, double-blind, single ascending dose (SAD) and multiple ascending dose (MAD) study to assess the safety, tolerability, and Pharmacokinetics (PK) of single and multiple ascending doses of MTX-439…
- Trial name
- NCT07473323
- Testing
- MTX-439
- Where
- Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Mediar Therapeutics
Focal Brain Lesion, Focal Lesions
Top-Down Attentional Control of Visual-Processing
Background: Previous studies have shown that people with certain types of brain damage may have particular problems paying attention and processing things that they see.
- Conditions
- Focal Brain Lesion, Focal Lesions, fMRI
- Trial name
- NCT01087281
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy
Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses
This study will use a method called dynamic light scattering (DLS) to study the lens of the eye in young normal subjects. The DLS device uses a very dim laser light to study the lens of the eye.
- Trial name
- NCT00304967
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Ebola Hemorrhagic Fever, Ebola Virus Disease
Experimental Vaccine for Prevention of Ebola Virus Infection
This study will determine if an experimental vaccine to prevent Ebola virus infection is safe and what side effects, if any, it causes.
- Conditions
- Ebola Hemorrhagic Fever, Ebola Virus Disease, Ebola Virus Vaccines, Envelope Glycoprotein, Ebola Virus
- Trial name
- NCT00374309
- Testing
- VRC-EBOADV018-00-VP
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neurocysticercosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28
The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.
- Trial name
- NCT00526916
- Testing
- [C-11]PBR28
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)