Clinical trials: Hansen's Disease
Leprosy
Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial
Team-based learning (TBL) is a learner-centered, instructor-directed strategy for small group active learning in large group educational settings.
- Trial name
- NCT02484469
- Testing
- The Virtual Human Project
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Atopic Dermatitis, Psoriasis
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatments is extremely variable.
- Conditions
- Atopic Dermatitis, Psoriasis, Hidradenitis Suppurativa, Lichen Planus
- Trial name
- ImmuneSkinBank (NCT06599411)
- Testing
- Sampling
- Where
- France
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leprosy
Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers
The purpose of this study is to compare the safety, tolerability, and immunogenicity in healthy adult subjects of an investigational vaccine being developed for the prevention of leprosy.
- Trial name
- NCT03302897
- Testing
- LEP-F1 + GLA-SE
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Access to Advanced Health Institute (AAHI)
Obesity, Leprosy
Effect of Weight and/or Obesity on Dapsone Drug Concentrations
This study will find how weight affects the dosing of a drug called dapsone. Currently, the amount of dapsone a patient receives is the same regardless of the patient's weight.
- Conditions
- Obesity, Leprosy, Tuberculosis
- Trial name
- NCT01165840
- Testing
- Dapsone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Muscle Injury, Nerve Injury
Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer
Foot drop deformity is a life limiting condition characterized by loss of ankle dorsiflexion and eversion. Main condition leading to drop foot condition include irrecoverable muscle and nerve injuries, poliomyelitis, drug…
- Conditions
- Muscle Injury, Nerve Injury, Poliomyelitis, Leprosy
- Trial name
- NCT01751503
- Testing
- Interosseous route of TPTT, Extra membranous route of TPTT
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Iva Hauptmannova
Leprosy
Novel Interventions and Diagnostic Tests for Leprosy
Contact with Mycobacterium leprae (M. leprae) infected individuals is a risk factor for development of leprosy. Thus, detection of asymtomatically M.
- Trial name
- INDIGO#2 (NCT06222372)
- Testing
- Rifampin
- Where
- Bangladesh
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Annemieke Geluk
Leprosy
Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar
This is a cluster randomized trial on effectiveness of different modalities of Single Double Dose of Rifampicin Post-Exposure Prophylaxis (SDDR-PEP) for leprosy in the Comoros (Anjouan and Mohéli) and Madagascar.
- Trial name
- PEOPLE (NCT03662022)
- Testing
- Rifampicin
- Where
- 3 sites in Comoros, Madagascar
- Volunteers
- 144,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Leprosy
Leprosy Active Searching Trial in Brazil
The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices.
- Trial name
- LAST•Br (NCT06761469)
- Testing
- Implementing active-case finding strategies
- Where
- Brazil
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Hospital Alemão Oswaldo Cruz
Leprosy
Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses
The purpose of this study is to determine what factors contribute to the continued incidence of leprosy in Colombia. Study participants will include volunteering and consenting individuals, older than 4 years of age, representing…
- Trial name
- NCT00138437
- Where
- 2 sites in Colombia
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Lepromatous Leprosy
Microcirculatory Impairment in Patients With Leprosy
In this study the investigators have aimed to evaluate morphology and reactivity of cutaneous microcirculation in patients with lepromatous leprosy.
- Trial name
- NCT02085317
- Testing
- acetylcholine Iontophoresis, sodium nitroprusside Iontophoresis
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Curt Treu
Leprosy
Serum Irisin Level In Leprosy Patients
Measurement of plasma irisin level in leprosy patients. Correlation of plasma irisin level between leprosy patients and healthy controls. Correlation of plasma irisin level in different leprosy types.
- Trial name
- NCT06416033
- Testing
- Serum Irisin
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Aswan University
Leprosy
Leprosy Skin Test Antigens Phase 1
This is a small Phase I trial to evaluate the safety of the use as skin test antigens of the immunologically active proteins from the soluble/cytosol and insoluble cell wall of Mycobacterium leprae.
- Trial name
- NCT01920750
- Testing
- MLCwA, MLSA-LAM, Mock Antigen
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leprosy
TGF β 1 Expression Related Gene Polymorphism
Leprosy is one of the oldest human infectious diseases. It is a chronic infectious contagious, granulomatous disease caused by intracellular bacillus.
- Trial name
- NCT06683690
- Testing
- Measurement of TGF- β1 in leprosy patients
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Leprosy
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
There will be two study arms. Arm 1 will be the intervention arm in which there will be provided BE-PEP to all persons residing within 100 meters of an index case, to be repeated after four weeks for household contacts.
- Trial name
- BE-PEOPLE P3 (NCT05597280)
- Testing
- BE-PEP Bedaquiline, SDR-PEP Rifampicin, BE-PEP Rifampicin
- Where
- Comoros
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Leprosy
Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients
This is a phase 1b/2a, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety, tolerability, and immunogenicity of the LEP-F1 + GLA-SE investigational vaccine compared to placebo.
- Trial name
- NCT03947437
- Testing
- LEP-F1 + GLA-SE
- Where
- Brazil
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Leprosy
Trial LEP-F1 + GLA-SE in Healthy Adult in Areas Endemic for Leprosy
This is a phase 1b, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety, tolerability, and immunogenicity of LEP-F1 + GLA-SE compared to placebo administered as three intramuscular (IM) injections…
- Trial name
- NCT06627257
- Testing
- LepVax (2 μg LEP-F1 + 5 μg GLA-S): Low dose, LepVax (10 μg LEP-F1 + 5 μg GLA-SE): High dose
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Leprosy
Leprosy Skin Test Antigens Trial
The purpose of this study is to see how healthy people and leprosy patients react to 2 new skin tests for detecting leprosy. The study will evaluate the new skin tests that may aid in measuring the number of people exposed to…
- Trial name
- NCT00128193
- Testing
- Tuberculin, Purified Protein Derivative, MLSA-LAM, MLCwA
- Where
- 6 sites in United States, Nepal
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leprosy
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy (Phase 2)
This study will evaluate a combination of bedaquiline and rifampicin as post exposure prophylaxis (PEP) for leprosy in Comoros. It will be a follow-up to the PEOPLE trial on PEP with rifampicin, which is ending in 2022.
- Trial name
- BE-PEOPLE P2 (NCT05406479)
- Testing
- BE-PEP (Bedaquiline), SDR-PEP, BE-PEP (Rifampicine)
- Where
- Comoros
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Hansen's Disease
Epidemiology of Leprosy in French Guiana
The main objective of the present study is the genotyping of M. leprae strains found in leprosy patients in French Guiana. The secondary objectives are to investigate the presence of M.
- Trial name
- EPI-LEPR (NCT05031091)
- Testing
- standardised exposure questionnaire
- Where
- French Guiana
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne