Clinical trials: Head Cancer Neck
Barrett Esophagus, Esophageal Cancer
Study to Evaluate EnteroTracker® as a Sampling Method to Screen for Barrett's Esophagus/Esophageal Cancer
The purpose of this study is to determine whether the EnteroTracker can obtain biomarkers that have been studied to be significant in screening BE and EAC.
- Trial name
- NCT05706025
- Testing
- EnteroTracker
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypopharyngeal Cancer, Laryngeal Cancer
A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions
This study aims to develop and validate a clinical prediction model for the risk of head and neck cancerous lesions using deep learning combined with AI algorithms, based on multi-center clinical data.
- Conditions
- Hypopharyngeal Cancer, Laryngeal Cancer, Head and Neck Cancer
- Trial name
- ML-HNC-Risk (NCT07532538)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Stage II-IVB Operable HNSCC Oral Cavity, Hypopharynx
Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.
This is a phase II randomized, open label study of durvalumab with/ without tremelimumab as neoadjuvant therapy and durvalumab maintenance after SoC RTx with/without cisplatin as post-surgical adjuvant therapy in treatment naïve…
- Conditions
- Stage II-IVB Operable HNSCC Oral Cavity, Hypopharynx, Oropharynx, Larynx
- Trial name
- NCT03737968
- Testing
- Durvalumab, durvalumab + tremelimumab
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Volatile Organic Compounds, Microbiome
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- Volatile Organic Compounds, Microbiome, Microbioata, Breath Analysis
- Trial name
- NCT05412758
- Testing
- Oral Stimulant Drink
- Where
- United Kingdom
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cancer Diagnosis, LungCancer
Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing
The goal of this observational study is to screen and differentiate common cancers in participants with or without suspicious lesions.
- Conditions
- Cancer Diagnosis, LungCancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT06036563
- Where
- 8 sites in China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Thyroid Nodular Disease
Microvascular Profiling of Nodules in the Thyroid Gland
The purpose of this study is to examine tiny blood vessels in different thyroid nodules using advanced ultrasound. In the long term, we hope this can help doctors better tell the difference between types of nodules and more…
- Trial name
- NCT07041307
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Head and Neck Cancer, Prostate Cancer
Application of High Resolution Diffusion-weighted MR Imaging Pulse Sequence in Head and Neck, and Prostate Cancers
Magnetic resonance imaging (MRI) is a diagnostic study that makes pictures of organs of the body using magnetic field and radio frequency pulses that can not be felt.
- Trial name
- NCT01535898
- Testing
- MRI scanner with sequence
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Thyroid Cancer
Thyroid Cancer Among Chornobyl Clean-up Workers in Ukraine: Pilot Study
Background: The Ukrainian Research Center for Radiation Medicine and the U.S. National Institutes of Health have been studying cancer risks and outcomes in individuals who participated in the decontamination clean-up process…
- Trial name
- NCT01265381
- Where
- Ukraine
- Volunteers
- 673 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Microbiota
the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism
Thyroid cancer is a common neck malignancy. Currently, total thyroidectomy or subtotal thyroidectomy is the main method for the treatment of thyroid cancer patients.
- Trial name
- NCT03574051
- Testing
- Probiotic
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Cardio-vascular Disease, Stroke Cancer
Improving Access to Control of Diseases for Women
The aim of this study is to evaluate the feasibility and acceptability of the model of delivering CHW-driven home-based comprehensive NCD control services aimed to prevent premature deaths from cardio-vascular diseases, stroke…
- Conditions
- Cardio-vascular Disease, Stroke Cancer, Breast Cancer, Oral Cancer
- Trial name
- IMPACD (NCT03604939)
- Testing
- Evaluation of social, cultural and behavioral factors, Evaluation of the feasibility and acceptability of delivery of early detections services
- Where
- India
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Thyroid Gland Carcinoma
Identification and Differentiation of Thyroid Nodules by Acoustic Imaging and Viscoelastic Parameters
This study is being done to identify and differentiate thyroid nodules by acoustic imaging and viscoelastic parameters.
- Trial name
- NCT06207188
- Testing
- Non-Interventional Study
- Where
- 3 sites in United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastro-esophageal Reflux
Evaluation of Esomeprazole in Treating Gastro-esophageal Reflux Disease (GERD) in Head and Neck Cancer Patients Exposed to Radiation Therapy
The purpose of this research study is to measure acid reflux into the throat both before and after medical treatment in people who have had radiation therapy to their head and neck for the treatment of cancer.
- Trial name
- NCT00222079
- Testing
- Esomeprazole (Nexium)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Douglas Trask
Adenoid Cystic Carcinoma, Salivary Gland Cancer
A Study of Sunitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands
This is a phase II study to evaluate the effectiveness of study drug sunitinib malate in patients with recurrent and/or metastatic adenoid cystic carcinomas of the salivary gland.
- Trial name
- NCT00886132
- Testing
- Sunitinib
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Localized Head and Neck Carcinoma
Geriatric Assessment and Management for Older Adults Undergoing Chemotherapy and Radiation Therapy for Head and Neck Cancer and Their Family Caregivers
This clinical trial compares the effect of geriatric assessment (GA)-based management of supportive care to usual care in treating older patients undergoing chemotherapy and radiation therapy for head and neck cancer and their…
- Trial name
- NCT07225855
- Testing
- Best Practice, Electronic Health Record Review, Health Communication
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Brain Cancer, Neck Cancer
Determine if Apparent Diffusion Coefficient (ADC) Values Can Differentiate Tumors From Normal Tissue
The purpose of this study is to determine normal measurements (ADC values) from the head and neck of healthy volunteers using 3T MRI.
- Trial name
- NCT00723463
- Testing
- 3T MRI scan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Adenocarcinoma Esophagus, Adenocarcinoma of the Stomach
Molecular Analysis of Gastric and OEsophageal Cancers STudy
A prospective translational tissue collection study to identify biomarkers predictive of treatment response/resistance and biomarkers of prognostic value from a series of patients who are investigated for and diagnosed with early…
- Conditions
- Adenocarcinoma Esophagus, Adenocarcinoma of the Stomach, Adenocarcinoma - GEJ, Squamous Cell Car. - Esophagus
- Trial name
- MAGnET (NCT06702384)
- Testing
- biopsy
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Head and Neck Carcinoma
Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers
This clinical trial tests how well a three-dimensional (3D) mindfulness virtual reality (VR) versus (vs) two-dimensional (2D) non-immersive interventions works in improving depression, anxiety, pain, and/or stress in patients…
- Trial name
- NCT06985784
- Testing
- Interview, Medical Device Usage and Evaluation, Questionnaire Administration
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Thyroid Cancer
Famitinib in Combination With Adebrelimab for the Treatment of Advanced Thyroid Cancer
This is a multi-cohort, open-label, single-centre, Phase 2 study aiming to investigate the efficacy and safety of a regimen using the multi-targeted kinase inhibitor Famitinib in combination with the PD-L1 antibody Adebrelimab…
- Trial name
- NCT06146985
- Testing
- 20 mg Famitinib & 1200 mg Adebrelimab
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Oral Cancer, Squamous Cell Carcinoma
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain
This is a prospective study involving human participants. Pressure and stretch sensitivity measures between oral cancer patients and healthy subjects will be compared.
- Trial name
- NCT07095608
- Testing
- Pressure and stretch sensitivity testing
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- New York University