Clinical trials: Head Injury Trauma, active
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Concussion Post Syndrome, Head Trauma Injury
Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients…
- Trial name
- IMPACT (NCT07634393)
- Testing
- Metoclopramide 10mg, Acetaminophen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Montefiore Medical Center
Mild Traumatic Brain Injury, Intracranial Lesions
TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms
The goal of this clinical study is to evaluate how accurately and safely the TES HT100 device can identify intracranial abnormalities in adult emergency department patients with mild head trauma or neurological symptoms that are…
- Conditions
- Mild Traumatic Brain Injury, Intracranial Lesions, Neurological Symptoms Not Related to Head Trauma
- Trial name
- TESCO (NCT07490418)
- Testing
- Temnographic Brain Screening Examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 850 people
- Sponsor
- B&B srl
Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury
Kids Injury Detection Study Using the i-STAT
KIDS-STAT is a prospective study evaluating whether a rapid blood test measuring the brain injury biomarkers GFAP and UCH-L1 using the i-STAT Alinity system can help identify children with mild traumatic brain injury who do not…
- Conditions
- Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury, Head Trauma
- Trial name
- KIDS-STAT (NCT07835919)
- Testing
- i-STAT TBI Cartridge with the i-STAT Alinity System
- Volunteers
- 700 people
- Sponsor
- Children's Healthcare of Atlanta
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Brain Injury Traumatic Mild, Brain Injuries
Screening Emotions in Adolescents at the Hospital for mTBI
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing…
- Conditions
- Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage
- Trial name
- SEARCH-mTBI (NCT06370520)
- Testing
- Validated Questionnaires, Questionnaires, Clinician / Medical Record Variables
- Where
- 6 sites in United States
- Volunteers
- 2,592 people
- Sponsor
- University of California, Davis
Brain Injuries, Head Injury
Biomarker Role in Assessing Imaging Needs for Mild Cranial Trauma
This study aims to determine whether a blood test can help doctors decide when to use a head CT scan for patients with a mild head injury.
- Trial name
- BRAIN-CT (NCT06932588)
- Testing
- Biomarker Testing using the Alinity Whole-blood TBI biomarker i-STAT
- Where
- United States
- Volunteers
- 351 people
- Sponsor
- Emory University
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Craniocerebral Trauma, Brain Injuries, Traumatic
Socio-Cultural Level, Health Literacy, and Parental CT Demand in Paediatric Minor Head Trauma
Minor head trauma is one of the most frequent reasons for paediatric emergency department visits worldwide. The PECARN (Paediatric Emergency Care Applied Research Network) clinical decision rule stratifies children with minor…
- Conditions
- Craniocerebral Trauma, Brain Injuries, Traumatic, Head Injuries, Closed
- Trial name
- NCT07655310
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Brain Injuries, Acute, Brain Trauma
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago).
- Conditions
- Brain Injuries, Acute, Brain Trauma, Penetrating Head Injury, Traumatic Brain Injury
- Trial name
- BRIDGE-US (NCT07636213)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Chicago
Head Injury
The "Concussion or Brain Bleed" Trial
Researchers are trying to understand the effect of educating patients and encouraging shared decision making on rates of CT scanning in head injured patients by using an already developed app and observing the effect on the…
- Trial name
- NCT04002505
- Testing
- Concussion and Brain Bleed App (CBB)
- Where
- United States
- Volunteers
- 370 people
- Sponsor
- Mayo Clinic
Head Injury, Traumatic Brain Injury
Selective CT for Anticoagulated Head Injured Patients
The goal is to derive and a clinical decision rule for safe exclusion of traumatic brain injury without neuroimaging in head-injured ED patients who take anticoagulant medications. The objectives are to: 1.
- Conditions
- Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head Injury
- Trial name
- Can-SCAHn (NCT05364749)
- Where
- 7 sites in Canada
- Volunteers
- 4,000 people
- Sponsor
- Dr. Kerstin de Wit
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Head Injury Trauma
Treatment and Outcome of Patients With Mild Head Injury
The study aims to assess the incidence of complications, such as intracranial haemorrhages and neurological deficits, in patients with head trauma treated in the emergency departments of the Emilia-Romagna Region and to compare…
- Trial name
- BTER23 (NCT07339319)
- Where
- 4 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Head Injury Trauma, Emergencies
Platelet Inhibitor Treated Patients With Head Injury Trauma Meeting NICE Criteria : is the CT-scan Mandatory ?
At the emergencies rooms, patients with head trauma meeting one of the NICE criteria, which include antiplatelet inhibitors treatment, are considered as patients with a risk of cerebral haemorrage and are taken systematically for…
- Trial name
- TCAP (NCT03687528)
- Testing
- CT-scanner
- Where
- 12 sites in France
- Volunteers
- 3,200 people
- Sponsor
- Rennes University Hospital
Head Trauma, Head Injury
Delayed IntraCranial Hemorrhage in Oral AntiCoagulant Treated Patients With Mild Traumatic Brain Injury
As a low quality, weak recommendation, it is part of the Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults, that patient with a GCS of 14-15 and anticoagulation therapy and a…
- Conditions
- Head Trauma, Head Injury, Delirium, Thrombosis
- Trial name
- dICH-OAC (NCT07195760)
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Head Injuries
Monitoring & Mitigation of Neurologic Injuries to Optimize Resilience After Repetitive Head Impacts
The purpose of this Phase 2, double-arm study is to identify repetitive, non-concussive head impacts that impair neurologic functioning, and to test treatments that can mitigate these effects and return functioning to normal as…
- Trial name
- MONITOR-RHI (NCT06810193)
- Testing
- Aerobic exercise
- Where
- 3 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Injuries, Head, Traumatic Brain Injuries
Point of Care Testing in Emergency Departments After Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is estimated to have the highest incidence of all common neurological disorders, affecting 50 to 60 million people worldwide each year.
- Trial name
- POCkET (NCT07129577)
- Volunteers
- 400 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Head Injury, Minor, Pediatric
Hypertonic Saline for Mild TBI in Pediatric Patients
The purpose of this study is to compare two different treatments (normal saline and hypertonic saline) for concussions to see if one makes more of a difference in symptoms that can occur following concussions.
- Conditions
- Head Injury, Minor, Pediatric, Emergency Department Patient
- Trial name
- NCT07060105
- Testing
- Hypertonic Saline ( 3% Sodium Chloride Saline), Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Texas at Austin
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati