Clinical trials: Head and Neck Cancer (H&N)
Head and Neck Cancer, Radiotherapy
Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer
The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT).
- Trial name
- ROOCT (NCT04610645)
- Testing
- OCT, Dermatoscope
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Acute Radiation Dermatitis, Head and Neck Cancer (H&N)
Effectiveness of 0.9% Normal Saline Soaking in Managing Acute Radiation Dermatitis
The goal of this clinical trial is to learn if normal saline soaks can reduce the severity of acute radiation dermatitis in patients with sarcomas or head and neck cancer receiving radiotherapy.
- Conditions
- Acute Radiation Dermatitis, Head and Neck Cancer (H&N), Sarcomas
- Trial name
- NCT07553260
- Testing
- Normal Saline Soaks (0.9% Sodium Chloride)
- Where
- Jordan
- Volunteers
- 150 people
- Sponsor
- King Hussein Cancer Center
Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck
Pilot Study of Imatinib Cetuximab Combo for H & N Cancer
The goal of this clinical trial is to find if levels of a protein called AXL in tumor cells relate to how tumors respond to cetuximab (CTX) combined with imatinib in participants with head and neck cancer.
- Trial name
- NCT05816785
- Testing
- Cetuximab, Imatinib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Basal Cell Carcinoma of the Head and Neck
Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N
The purpose of this study is to evaluate anti-PD-1 Neoadjuvant therapy in Basal cell carcinoma to provide a better outcome when administered prior to surgery and provide a therapeutic strategy to avoid surgery altogether.
- Trial name
- NCT04323202
- Testing
- Pembrolizumab, Tissue collection
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Adenoid Cystic Carcinoma
Trail Evaluating Particle Therapy With or Without Apatinib for H&N Adenoid Cystic Carcinoma
It is a randomized phase II study to determine the efficacy and safety of particle therapy with or without apatinib as induction therapy for the treatment of head and neck adenoid cystic carcinoma.
- Trial name
- NCT02942693
- Testing
- Apatinib, Particle Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Head Neck Tumors, Neuroendocrine Tumors
A Phase II Study on Adjuvant Vaccination with Dendritic Cells Loaded with Autologous Tumor Homogenate in Resected Stage IV Rare Cancers.
Single-arm, monocentric trial to assess safety and immunological efficacy of adjuvant vaccination with autologous dendritic cells loaded with autologous tumour homogenate after curative resection for stage IV rare cancers (In…
- Conditions
- Head Neck Tumors, Neuroendocrine Tumors, Soft Tissue Sarcoma, Rare Cancer
- Trial name
- RaC-Ad (NCT04166006)
- Testing
- Autologous DC vaccine, Interleukin-2
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Breast Cancer, Head and Neck Cancer (H&N)
Evaluation of [⁶⁸Ga/¹⁷⁷Lu]HT547: Safety, Biodistribution, and Dosimetry in Solid Tumors
Urokinase plasminogen activator receptor (uPAR), the cell-surface receptor for its ligand uPA, plays a critical role in regulating cell migration and invasion-key drivers of cancer progression.
- Conditions
- Breast Cancer, Head and Neck Cancer (H&N), Pancreatic Cancer, Glioma
- Trial name
- NCT07639970
- Testing
- [⁶⁸Ga]Ga-HT547 and [¹⁷⁷Lu]Lu-HT547
- Volunteers
- 20 people
- Sponsor
- Hua Pang
Gastric Cancer, Colorectal Cancer
Oral, Fecal and Intratumoral Microbiome Atlas in Colombian Patients With Advanced Solid Tumors Receiving First-Line Immunotherapy
This is a prospective observational cohort study conducted at Fundación CTIC in Bogotá, Colombia. It characterizes the oral, fecal and intratumoral microbiome of Colombian adults with advanced solid tumors (gastric, colorectal…
- Conditions
- Gastric Cancer, Colorectal Cancer, Breast Cancer, Cervical Cancer
- Trial name
- ATLAS (NCT07676461)
- Testing
- First-line immunotherapy (immune checkpoint inhibitors), INVIMA-approved, standard of care
- Where
- Colombia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Head and Neck Cancer (H&N)
Effects of Far Infrared Rays and Transcutaneous Electrical Nerve Stimulation on Short Term Prognosis of Head and Neck Cancer Patients Receiving Curative Treatment
The goal of this clinical trial is to determine whether far-infrared therapy and transcutaneous electrical nerve stimulation (TENS) can improve postoperative side effects in patients with head and neck cancer.
- Trial name
- NCT07334938
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Far-Infrared Therapy
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Head and Neck Carcinoma, Head and Neck Lymph Node
Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer
This trial studies how well photoacoustic imaging works in measuring tumors and normal tissue in patients with head and neck cancer.
- Conditions
- Head and Neck Carcinoma, Head and Neck Lymph Node, Head and Neck Squamous Cell Carcinoma, Laryngeal Neoplasm
- Trial name
- NCT04110249
- Testing
- Photoacoustic Imaging, Transcutaneous Acupoint Electrical Stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Roswell Park Cancer Institute
Head and Neck Cancer
Comparison of AIRVO High Flow Oxygen Therapy With Standard Care for Prevention of PPCs After Major H&N Surgery
Patients undergoing major head and neck surgery often develop breathing difficulties as a result of build up of sputum and difficulty taking deep breaths.
- Trial name
- NCT03828578
- Testing
- High flow oxygen therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cardiff and Vale University Health Board
Head and Neck Cancer (H&N)
Effects of Far Infrared Rays and Transcutaneous Electrical Nerve Stimulation on Short Term Prognosis of Head and Neck Cancer Patients Receiving Curative Treatment
This clinical trial aims to evaluate whether far infrared radiation therapy and transcutaneous electrical nerve stimulation can reduce treatment-related side effects in patients with head and neck cancer undergoing concurrent…
- Trial name
- NCT07689019
- Testing
- Standard Care (in control arm), Transcutaneous Electrical Nerve Stimulation, Far-Infrared Therapy
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Head and Neck Cancer
Megestrol Acetate Against Cancer-related Critical Body Weight Loss in Patients With H&N Cancer Who Receiving CCRT
Primary Objective: To evaluate the population prevalence of critical body weight loss ( more than 5% from baseline) in patients with Head and Neck cancer.
- Trial name
- NCT02980653
- Testing
- Megestrol acetate (MA) 400 mg/day
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- TTY Biopharm
Head and Neck Cancer
Anti-platelet + Pembro for H&N Tumors
The purpose of this study is to see if anti-platelet therapy combined with anti-PD-1 immunotherapy can cause a more favorable immunologic response thatn with immunotherapy alone in patients with recurrent or metastatic squamous…
- Trial name
- NCT03245489
- Testing
- Pembrolizumab, Clopidogrel, acetylsalicylic acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Head and Neck Cancer (H&N)
Prophylactic Intervention for Dysgeusia in Head and Neck Cancer Patients Following Radio(Chemo)Therapy
Taste changes, also called dysgeusia, affect 56-76% of patients with head and neck cancer treated with radiotherapy (with or without chemotherapy).
- Trial name
- DYSGRAD (NCT07431346)
- Testing
- Prophylactic dysgeusia intervention
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Jules Bordet Institute
Head and Neck Cancer, Carcinoma, Squamous Cell
Cervical Nodal Mets in Squamous Cell Carcinoma of H&N - MRI, FDG-PET, & Histopathologic Correlation
The purpose of this study is to determine the value of novel non-invasive medical imaging methods for detecting the spread of head and neck squamous cell carcinoma to the lymph nodes in the neck by comparing their results to…
- Conditions
- Head and Neck Cancer, Carcinoma, Squamous Cell, Head and Neck Cancers
- Trial name
- NCT00313027
- Testing
- PET scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Head and Neck Cancer
Effect of a Nutritional Supplement on H&N Cancer Patients
To determine if using a nutritionally enhanced supplement will improve mucositis in head and neck cancer patients
- Trial name
- NCT00296452
- Testing
- behavior
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Edward Hines Jr. VA Hospital
Thyroid Pathology, Head and Neck Cancer (H&N)
FAPI PET Imaging - An Exploratory Study
This study is testing a new imaging tracer called [18F]FAPI-74 with PET scans. Researchers want to find out how well this tracer shows certain diseases in the body, including several types of cancer and some non-cancer conditions…
- Conditions
- Thyroid Pathology, Head and Neck Cancer (H&N), Sinonasal Tract Tumor, Sarcoidosis
- Trial name
- FAPIPET (NCT07705074)
- Testing
- [18F]FAPI-74 PET/CT
- Where
- 5 sites in Switzerland
- Volunteers
- 770 people
- Sponsor
- Martin Huellner
Radiotherapy; Complications, Head and Neck Cancer
Individualization of Nutritive Sensory Support Of Radiation Therapy
Nutritional deficiency and subsequent weight loss in patients with head and neck cancer is a common problem and a negative predictor of treatment outcomes and mortality, as well as quality of life.
- Trial name
- NCT05046028
- Testing
- Oral nutritional supplements (ONS) with a cooling effect + ONS without a sensor component and taste + standard diet, ONS without a sensor component and taste + standard diet, Standard diet
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Radiological Centre of the Ministry of Health of Russia