Clinical trials: Head and Neck Carcinoma
Nasopharyngeal Carcinoma
Screening Effect of Dual-energy CT Combined With Nasopharyngeal Endoscopy for Screening Nasopharyngeal Carcinoma
All participants will be tested for EBV-related biomarkers, including EBNA1-IgA, VCA-IgA, and BNLF2b total antibody (P85-Ab), and participants with high serologic risk will be selected based on serologic test results, and…
- Trial name
- NCT05884983
- Testing
- participants will undergo dual-energy CT and endoscopy
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Breast Cancer, Lung Cancer
Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies.
Novel treatment modalities like targeted therapies and Immune checkpoint inhibitors have revolutionised the therapeutic landscape in oncology and hematology, significantly improving outcomes even in clinical contexts in which…
- Conditions
- Breast Cancer, Lung Cancer, Melanoma, Head and Neck Cancer
- Trial name
- POSITive (NCT06321640)
- Testing
- Cohort A: primarily operable disease, candidate to adjuvant, Cohort B: locally advanced disease, Cohort C: metastatic disease
- Where
- Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Nasopharyngeal Carcinoma
Intestinal Flora Sequencing for Nasopharyngeal Carcinoma
This study investigated the correlation between the changes in the intestinal flora and NPC by an examination of the intestinal flora and multiple clinical indicators of the blood of 8 carefully screened patients of familial NPC…
- Trial name
- NCT04094545
- Where
- China
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Nasopharyngeal Carcinoma, EBV Infection
A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Nasopharyngeal Carcinoma.
The transformation process of nasopharyngeal carcinoma is complex, so it is particularly important to explore the relationship between various disease states on its clinical pathway.
- Trial name
- NCT05682703
- Testing
- Proteomics technology and liquid biopsy
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Head and Neck Squamous Cell Carcinoma
Evaluation of OE-MRI in Patients With H&N Cancer
Assessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.
- Trial name
- NCT04724096
- Testing
- Oxygen Enhanced MRI scan
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Oral Cancer, Oral Squamous Cell Carcinoma
Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study
The study will include patients with oral cancer and healthy controls of both sexes. Subjects having any systemic diseases or other types of cancer will be excluded.
- Trial name
- NCT06031337
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Squamous Cell Carcinoma
A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.
Given the feasibility of induction chemotherapy in oral cancer and the encouraging remission rates achieved, we explore the clinical application prospects of using tislelizumab in combination with traditional standard…
- Trial name
- B2023-153 (NCT06130007)
- Testing
- Three-Week Treatment Regimen with Trastuzumab in Combination with Docetaxel and Platinum Triple Therapy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Xuekui Liu
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Ann Arbor Stage I Lymphoma, Ann Arbor Stage II Lymphoma
- Trial name
- NCT05334069
- Testing
- Questionnaire Administration, Biospecimen Collection
- Where
- 751 sites in United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
The Families or Next of Kin of Patients Treated at MSKCC for Non-cutaneous Squamous Cell Carcinomas of the, Upper Aerodigestive Tract
Improving End of Life Care in Head and Neck Cancer
The purpose of this study is to improve the quality of care provided for head and neck cancer patients. By better understanding the end of life experiences of dying patients and their families, the investigators hope to better…
- Trial name
- NCT01632969
- Testing
- The The Family Assessment of Treatment at the End of life (FATE ) survey
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Colorectal Cancer
UMCC 003 Cancer-Related Protein Biomarkers in Blood and Tumor Tissue of Patients With Cancer
RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer and blood from healthy participants may help doctors learn more about changes that may occur in DNA and identify biomarkers related…
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Liver Cancer
- Trial name
- IRB 2000-294 (NCT00900094)
- Testing
- fluorescence in situ hybridization, polymerase chain reaction, protein expression analysis
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Caregiver, Head and Neck Carcinoma
Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or Lung Cancer Undergoing Surgery or Chemoradiation and Their Caregivers
This trial studies comprehensive geriatric and quality of life assessments in older patients with head and neck or lung cancer that has or has not spread to other parts of the body who are undergoing standard surgery or…
- Conditions
- Caregiver, Head and Neck Carcinoma, Lung Carcinoma, Metastatic Head and Neck Carcinoma
- Trial name
- NCT03902535
- Testing
- Comprehensive Geriatric Assessment, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Squamous Cell Carcinoma of Head and Neck
MicroRNA Markers in Head and Neck Cancers
The purpose of this study is to investigate the presence of miRNA markers in saliva, blood, FNA and tissue specimens in patients with and without head and neck cancer and evaluate whether these miRNA markers can provide…
- Trial name
- NCT04305366
- Testing
- Tissue collection
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Oral Lichen Planus, Oral Squamous Cell Carcinoma
Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity
The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.
- Trial name
- NCT03026361
- Testing
- global proteomic profiling
- Where
- Croatia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Head and Neck Squamous Cell Carcinoma, Anal Cancer
Blood Biomarkers Based Screening for HPV-driven OPC
The objective of our study is to demonstrate that it is possible to detect and treat human papilloma virus (HPV)-related oropharyngeal cancers (OPC) early using simple blood tests.
- Conditions
- Head and Neck Squamous Cell Carcinoma, Anal Cancer, Human Papilloma Virus
- Trial name
- SCREEN-HPV (NCT06528353)
- Testing
- HPV16-E6 serology and HPV ctDNA
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- UNICANCER
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma
Saliva-based Detection of CD44
The purpose of this study is to test the ability of OncAlert™ to screen for cancer and the reappearance of cancer. OncAlert™ was developed by Vigilant Biosciences, a collaborator in this research study.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Oropharynx, Squamous Cell Carcinoma of the Head and Neck
- Trial name
- Detect 44 (NCT03148665)
- Testing
- OncAlert
- Where
- 4 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Joseph Califano
Oral Cavity Carcinoma
Behavior Changing Intervention for Smokeless Tobacco and Betel Quid Use in Adolescents
Smokeless tobacco (SLT) is a known risk factor for Oral, Pharyngeal and Esophageal carcinoma. Three-quarters global SLT consumption is among the South Asian Population.
- Trial name
- NCT03488095
- Testing
- BCI for SLT and BQ Use in Adolescents: A CRT
- Where
- Pakistan
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Nasopharyngeal Carcinoma, Early Diagnosis of Cancer
Methylation-specific PCR Test for Early Screening and Early Diagnosis of Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma is one of the most common malignant tumors in China, with the progress of radiochemical comprehensive treatment, early stage The 5-year survival rate of nasopharyngeal cancer is more than 95%.
- Trial name
- NCT06367049
- Testing
- Methylation-specific PCR
- Where
- China
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Malignancies, Stomach Cancer
The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies.
This is an open-label, single arm study to explore whether 18F-ALF-NOTA-PRGD2 PET/CT scan can predict the efficacy and adverse events of apatinib in patients with malignancies.
- Conditions
- Malignancies, Stomach Cancer, Non-small Cell Lung Cancer, Esophageal Cancer
- Trial name
- NCT03384511
- Testing
- Apatinib
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shandong Cancer Hospital and Institute