Clinical trials: Head and Neck Disorder
Barrett's Esophagus, Esophageal Neoplasm
Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA) 2.
- Trial name
- FBE (NCT00288119)
- Testing
- Balloon Capsule Device, Endoscopy
- Where
- 10 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Oesophageal Cancer
Unintentional Weight Loss After Oesophagectomy
The incidence of cancer of the oesophagus is increasing. While surgical removal of the tumour (oesophagectomy) may offer the best chance of cure, such major operations are associated with long-term complications such as poor…
- Trial name
- UWL (NCT05074914)
- Testing
- oesophagectomy
- Where
- Ireland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders
Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer Triage
This research study evaluates an experimental, point-of-care tool that combines Deep Ultraviolet (DUV) light imaging with Artificial Intelligence (AI) to rapidly screen for oral cancer and pre-cancer (dysplasia).
- Conditions
- Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Cancer
- Trial name
- DEEP UV-M (NCT07842211)
- Testing
- Deep UV-M and AI Cytology Triage
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Anh Le
Esophageal Cancer, Precancerous Condition
Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus
RATIONALE: A tethered capsule endoscope may be as effective as standard sedated endoscopy of the esophagus, stomach, and duodenum in screening for Barrett esophagus.
- Trial name
- NCT00903136
- Testing
- questionnaire administration, comparison of screening methods, diagnostic endoscopic procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Oral Cancer, Oropharyngeal Cancer
Speech-based AI-driven Diagnostics and Rehabilitation for Oral and Oropharyngeal Cancer.
Participants diagnosed with oral cancer, oropharyngeal cancer, or oral potentially malignant lesions, as well as healthy controls, had their speech audio recordings collected for the development and validation of AI-driven models…
- Trial name
- speech omics (NCT07347899)
- Where
- China
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Yudong Xiao
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT06700863)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Reconstructive Surgery After Carcinological Excision
Evaluation of the Interest of the Neurorrhaphy in Resensitizing Free Flaps
The surgical procedure consists in removing a tumor of the oral cavity and then repairing the oral defect by the use of a free flap.
- Trial name
- NCT03677349
- Testing
- neurorrhaphy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Thyroid Cancer
Outcome of RAI131 Therapy in Patients With Differentiated Thyroid Cancer (Low and Intermediate Risk)
Thyroid cancer is a universally relatively rare neoplasm, accounting for nearly 1-5% of all female cancers and less than 2% of male cancers.
- Trial name
- NCT07056218
- Testing
- neck ultrasound, thyroglobulin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Work-Related Condition, Musculoskeletal Health
Relationship Between Neck Posture and Stiffness of Head and Neck Muscles, Pain and Proprioception in Desk Workers
In our study, posture in desk workers; it aims to evaluate the relationship between cervical range of motion, proprioception, muscle stiffness, posture and pain.
- Trial name
- NCT06012773
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Pınar Kuyulu
Esophagus Cancer, Esophageal Cancer
Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow During Esophageal Surgery in Humans
ActivSight™ combines an innovative form factor and proprietary software to deliver precise, objective, real-time visualization of blood flow and tissue perfusion intraoperatively for laparoscope-based surgery.
- Conditions
- Esophagus Cancer, Esophageal Cancer, Esophageal Neoplasms, Esophageal Diseases
- Trial name
- NCT05591053
- Testing
- ActivSight
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Activ Surgical
Esophageal Squamous Cell Carcinoma
High-concentration Small-volume Versus Low-concentration Large-volume Iodine Solution for Esophageal Chromoendoscopy
This clinical trial aims to test the participants' tolerance for different concentration iodine solutions during esophageal chromoendoscopy.
- Trial name
- NCT06063941
- Testing
- 1% Lugol's iodine solution, 5% Lugol's iodine solution
- Where
- 5 sites in China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Thyroid Abnormalities, Thyroid
Ultrasound Large-scale Model in Thyroid Field: A Multi-center Study on Medical-Engineering Integration
The goal of this observational study is to evaluate the diagnostic accuracy and clinical workflow integration of an ultrasound intelligent agent (UIA) for thyroid disease management in a real-world multicenter setting.
- Conditions
- Thyroid Abnormalities, Thyroid, Thyroid Cancer
- Trial name
- NCT07296575
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Head and Neck Cancer, Chronic Periodontitis
Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy Side Effect
- Trial name
- HNCs (NCT06529588)
- Testing
- Radiation
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery
Does Craniosacraltherapy Combined With Exercises That Focuses om Respiration and Posture in the Upper Body Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
The current study aims to assess the efficacy of manual treatment with craniosacral therapy of fascial tissue in throat, neck, cranial and mouth region, on radiation and/or surgery-induced salivary gland hypofunction and…
- Conditions
- Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery, Other Late Sequelae Following Radiotherapy and Cancer Surgery in Neck or Head
- Trial name
- NCT05882890
- Testing
- Craniosacral Therapy, Exercices Targeting Upper Posture and Respiration
- Where
- 2 sites in Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cathrine Rahbek
Esophageal Cancer
The Diagnostic Value of Nitrogen Element (N) in Esophagus Cancer
The purpose of this study is to determine the diagnostic value of various nitrogen components in oral gas for esophagus cancer (ESCA) .
- Trial name
- NCT05494359
- Testing
- The nitrogen isotope
- Where
- 3 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Nasopharyngeal Carcinoma, EBV Infection
A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Nasopharyngeal Carcinoma.
The transformation process of nasopharyngeal carcinoma is complex, so it is particularly important to explore the relationship between various disease states on its clinical pathway.
- Trial name
- NCT05682703
- Testing
- Proteomics technology and liquid biopsy
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Nasopharyngeal Carcinoma
Nasopharyngeal Carcinoma Post IMRT
Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. The last three decades of research in head and neck radiation oncology have largely focused on improvements in survival, which have mostly come at the cost of long…
- Trial name
- NCT02597426
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage I Squamous Cell Carcinoma of the Oropharynx
Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors
This pilot clinical trial studies freeze-dried black raspberries (BRB) in preventing oral cancer recurrence in high at-risk Appalachian patients previously treated with surgery for oral cancer.
- Conditions
- Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage I Squamous Cell Carcinoma of the Oropharynx, Stage I Verrucous Carcinoma of the Oral Cavity, Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT01504932
- Testing
- BRB Lozenge, Survey Administration, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center