Clinical trials: Headache, Cluster
Cluster Headache
Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks
Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache…
- Trial name
- NCT00458770
- Testing
- position emission transaxial tomography
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Headache Disorders, Primary, Headache Disorders, Secondary
China Headache and Vertigo Registry Study
In the Chinese Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular…
- Conditions
- Headache Disorders, Primary, Headache Disorders, Secondary, Migraine, Tension-Type Headache
- Trial name
- CHRS (NCT04939922)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Cluster Headache
SPG Neurostimulation in Cluster Patients
We hypothesized that LF stimulation of the SPG would increase parasympathetic outflow, activate sensory afferents and provoke a cluster-like attack.
- Trial name
- NCT02510729
- Testing
- Neurostimulation
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Cluster Headache
Efficacy and Safety of Zolmitriptan by Sublingual Administration
The purpose is to evaluate the effectiveness and safety profile of zolmitriptan by Sublingual administration for the acute treatment of Cluster headache.
- Trial name
- NCT03377257
- Testing
- zolmitriptan by sublingual administration, zolmitriptan by oral
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Episodic Cluster Headache
A Study Of Galcanezumab In Participants With Episodic Cluster Headache
The main purpose of this study is to evaluate the efficacy and safety of the study drug known as Galcanezumab in participants with episodic cluster headaches.
- Trial name
- NCT02397473
- Testing
- Galcanezumab
- Where
- 47 sites in United States, Belgium and 10 more
- Volunteers
- 109 people
- Sponsor
- Eli Lilly and Company
Cluster Headache
The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache
The investigators aim to investigate the effectiveness and safety of sphenopalatine ganglion pulsed radiofrequency on cluster headache.
- Trial name
- NCT03567590
- Testing
- Pulsed Radiofrequency treatment, Nerve Block treatment
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Migraine, Cluster Headache
mBrain-21 : a Three-month Study on Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache
This study collects data from migraine and cluster headache patients during a three-month study. Contextual data (e.g. location or smartphone usage) and physiological variables will be used to assist machine learning algorithms…
- Trial name
- MBRAIN-21 (NCT04983186)
- Testing
- Wearable sensor and smartphone application
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Cluster Headache
Pathway CH S&E Registry
Monitor the safety and performance of the Pulsante Microstimulator System.
- Trial name
- SER (NCT02440776)
- Where
- 9 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people
- Sponsor
- Autonomic Technologies, Inc.
Cluster Headache
Cluster Headache Treatment With Rimegepant
The purpose of this research is to explore the efficacy of rimegepant as a preventative therapy for cluster headache.
- Trial name
- NCT05264714
- Testing
- Rimegepant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chronic Cluster Headache
Sphenopalatine Ganglion Stimulation for the Treatment of Chronic Cluster Headache
The primary objective of the study is to demonstrate the safety and efficacy of SPG stimulation with the ATI Neurostimulation System when used to treat acute cluster attacks in chronic cluster headache patients.
- Trial name
- NCT02168764
- Testing
- ATI Neurostimulation System
- Where
- 24 sites in United States
- Volunteers
- 120 people
- Sponsor
- Autonomic Technologies, Inc.
Headache, Cluster
SPG Pulsed Radiofrequency for Chronic Cluster Headache
Cluster headache (CH) is a devastating disorder characterized by ipsilateral headache and associated trigeminal autonomic symptoms, with a yearly prevalence of 0.1%.
- Trial name
- NCT06787677
- Testing
- PRF, NB
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Cluster Headache
Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks
The goal of this clinical trial is to evaluate the efficacy of low sodium oxybate (LXB) (brand name Xywav) in the treatment of (nocturnal) cluster headache attacks in subjects with chronic cluster headache.
- Trial name
- SUNCET (NCT06950281)
- Testing
- Low Sodium Oxybate
- Volunteers
- 52 people
- Sponsor
- Leiden University Medical Center
Chronic Cluster Headache
Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache
The purpose of the proposed clinical study is to evaluate the use of an implanted Neurostimulator to provide Sphenopalatine Ganglion (SPG) stimulation for the management of the pain associated with cluster headaches.
- Trial name
- NCT01255813
- Testing
- Stimulation (Sub-perception), Stimulation (Full), Control
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 43 people
- Sponsor
- Autonomic Technologies, Inc.
Migraine, Cluster Headache
Intranasal Cooling for Cluster Headache and Migraine
This study will be looking at the clinical efficacy of using a intranasal evaporative cooling device in providing relief of the symptoms of migraine and cluster headache.
- Trial name
- COOLHEAD (NCT01898455)
- Testing
- RhinoChill intranasal cooling
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Cluster Headache
Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache
Background: After no official research in humans in the last 40 years, research and therapeutic uses of the serotonergic psychedelic lysergic acid diethylamide (LSD) are now re-recognized and include its use in brain research…
- Trial name
- LCH (NCT03781128)
- Testing
- Lysergic Acid Diethylamide
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Episodic Cluster Headache
R-Verapamil for the Prophylaxis of Episodic Cluster Headache
This is a double-blinded, randomized, parallel, placebo-controlled phase 2 study to evaluate the safety and efficacy of R-verapamil in the prophylaxis of episodic cluster headache.
- Trial name
- NCT02209155
- Testing
- R-verapamil 75 mg tablet
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Center Laboratories, Inc.
Cluster Headache
PACAP-38 Infusion in Patients With Cluster Headache
A randomized, double-blinded, two-way crossover study investigating the headache inducing capabilities of PACAP-38 in patients with cluster headache.
- Trial name
- NCT03814226
- Testing
- Evaluation of headache inducing capabilities of PACAP38
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Danish Headache Center
Cluster Headache
The Efficacy of L-cysteine in Prevention of Cluster Headache
The purpose of this study is to validate the novel hypothesis that daily use of L-cysteine (Acetium® capsules) is an effective means to decrease the frequency of (or completely abort) the attacks of cluster headache.
- Trial name
- NCT02310828
- Testing
- Acetium
- Where
- 6 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Biohit Oyj
Chronic Cluster Headache
Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care
Subjects enrolled into this 10 week study will for the first two weeks document the number of cluster headaches and the means of treating (medication) of these attacks. Subjects will then be randomized to into either two groups.
- Trial name
- NCT01701245
- Testing
- GammaCore
- Where
- 10 sites in Belgium, Germany and 2 more
- Volunteers
- 97 people
- Sponsor
- ElectroCore INC