Clinical trials: Health Impairment
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
The Digital Memory Notebook
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory…
- Conditions
- Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
- Trial name
- DMN (NCT04240665)
- Testing
- Digital Memory Notebook (DMN) Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Limbic Encephalitis With LGI1 Antibodies
Antibody-mediated LGI1 Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Chronic Phase of the Disease
The encephalitis mediated by antibodies against Leucine-rich, glioma inactivated 1 protein (anti-LGI1 encephalitis) predominantly affects men (M:F, 6:4) and mostly older than 60 years.
- Trial name
- NCT06515106
- Testing
- Remote cognitive rehabilitation program
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Hypoparathyroidism, Pseudo Hypoparathyroidism
QoL and Cognitive Function in Patients With Hypoparathyroidism
Hypoparathyroidism (HypoPT) is a disease with inadequate production of parathyroid hormone (PTH) from the parathyroid glands leading to hypocalcemia.
- Trial name
- MR-hypoPT (NCT04569604)
- Testing
- MRI scans, Neuro cognitive tests, Questionnaires on Quality of Life
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Stroke, Ischemic Stroke
Dietary Intervention With the Modified Atkins Diet in Stroke Rehabilitation
This phase 1 study tests whether use of the Modified Atkins Diet (MAD) can improve motor impairment after stroke. It is based on the hypothesis that after stroke, the brain's utilization of glucose, it's primary source of energy…
- Trial name
- NCT01820663
- Testing
- Modified Atkins Diet, Control diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Burke Rehabilitation Hospital
Cognitive Impairment (CI)
Post-operative Functional Disability in Unrecognized Cognitive Impairment (POF) Study
This is a prospective multicenter cohort study, which will determine the prevalence of preoperative cognitive impairment (CI) using the Modified Telephone Interview for Cognitive Status (TICS-M), Eight-items interview to…
- Trial name
- NCT04850833
- Where
- 2 sites in Canada
- Volunteers
- 390 people
- Sponsor
- University Health Network, Toronto
Disorder of Consciousness, Minimally Conscious State
Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Cognitive Impairment
- Trial name
- STIMCOM (NCT03007784)
- Testing
- transcranial direct current stimulation (tDCS) / Comparison of current intensities
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Alzheimer's Disease (AD) and Related Disorders
A Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders
A Multicenter national prospective cohort study including at least 2300 individuals consecutively recruited from French Research Memory Centers and followed-up over 5 years.
- Trial name
- MEMENTO (NCT01926249)
- Where
- 29 sites in France
- Volunteers
- 2,325 people
- Sponsor
- University Hospital, Bordeaux
Fatigue, Dyspnea
TaiChi-DTx for Treating Long Covid Symptoms
The randomized controlled trial will be conducted to evaluate the effectiveness of a Multi-domain Tai Chi Digital Therapy for treating the individuals suffering from the long term COVID-19 syndrome (Long COVID).
- Conditions
- Fatigue, Dyspnea, Cognitive Impairment, Muscle Pain
- Trial name
- TaiChi-DTx (NCT05419219)
- Testing
- the multi-domain Tai Chi Digital therapy Software Application
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tim Shi
Coronary Disease
Reduced Manipulation of the Aorta and Neurobehavioral Outcome Trial
The purpose of this trial is to determine whether aortic manipulation in patients undergoing coronary bypass graft surgery leads to increased incidence of microemboli and subsequent impairment of neurobehavioral function.
- Trial name
- NCT00059319
- Testing
- single aorta clamp with retrograde cardioplegia, multiple aorta clamps with antegrade cardioplegia
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Vascular Parkinsonism
Exploration of the Association Between White Matter Lesion Burden and Dalfampridine Response in Insidious-Onset Vascular Parkinsonism
This single-center observational cohort study will be conducted at Tangdu Hospital, Fourth Military Medical University. Patients presenting parkinsonism and poor levodopa response will be enrolled, including insidious-onset…
- Trial name
- DAL-VaP (NCT07682428)
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Tang-Du Hospital
Hearing Loss, Sensorineural, Hearing Impairment, Sensorineural
A Study Protocol for the Validation of UAud in a Clinical Setting.
The objective of this study is to validate the User-operated Audiometry (UAud) system for user-operated audiometry in a clinical setting, by investigating if hearing rehabilitation based on UAud is non-inferior to hearing…
- Trial name
- NCT05043207
- Testing
- uAud, Traditional audiometry
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Stroke, Hemiparesis
Telerehabilitation Through Serious Games in Virtual Reality in a Stroke Population (AutoRReVi)
After a stroke, individuals present with motor and/or cognitive impairments. These impairments limit activity, restrict participation and affect quality of life.
- Conditions
- Stroke, Hemiparesis, Cognitive Impairment, Healthy Subjects
- Trial name
- AutoRReVi (NCT04694833)
- Testing
- Motor and cognitive virtual reality-based assessments, Motor and cognitive virtual reality-based serious games
- Where
- Belgium
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Hepatitis B
Phase 1 Study of GSK3228836 Pharmacokinetics in Participants With Hepatic Impairment
This is a Phase 1, open-label, parallel-group study to evaluate the pharmacokinetics of GSK3228836 in participants with Child-Pugh B (CP-B) cirrhosis (moderate hepatic impairment), Child-Pugh A (CP-A) cirrhosis (mild hepatic…
- Trial name
- NCT04971928
- Testing
- GSK3228836
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Renal Impairment
Evaluating Patients With Varying Degrees of Renal Function
This is a Phase I, open-label study evaluating the PK of S-1 components and their metabolites in patients with advanced solid tumors and varying degrees of renal function.
- Trial name
- NCT00398307
- Testing
- S-1/Cisplatin
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Taiho Oncology, Inc.
Renal Function Impairment in Healthy Volunteers
Effects of the NO-synthase Inhibitor VAS203 on Renal Function in Healthy Volunteers
Analysis of the effect of the NO-Synthase inhibitor VAS203 (6 hours infusion of 10 mg/kg) on renal function and perfusion in 16 healthy subjects.
- Trial name
- NCT02992236
- Testing
- VAS203, Saline
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- veriNOS operations GmbH
Hepatic Impairment
A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic Function.
The primary purpose of this open-label study is to characterize the plasma pharmacokinetics (PK) of manogepix (active moiety of fosmanogepix) in participants with varying degrees of hepatic function following administration of a…
- Trial name
- NCT05582187
- Testing
- Fosmanogepix
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Mild Cognitive Impairment (MCI), Opioid Use
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
Mild cognitive impairment (MCI) affects a substantial proportion of older adults undergoing major surgery and may alter pain processing, pain experience, and opioid use after surgery.
- Conditions
- Mild Cognitive Impairment (MCI), Opioid Use, Cognitive Dysfunction, Postoperative Pain
- Trial name
- NCT07885085
- Where
- United States
- Volunteers
- 552 people
- Sponsor
- Miklos Kertai
Developmental Language Disorder and Language Impairment, Deprivation
Evaluating a Targeted Selective Speech, Language, and Communication Intervention at Scale - Protocol for the 'Happy Talk' Cluster Randomised Controlled Trial.
The overall aim of this clinical trial is to evaluate an at scale version of 'Happy Talk' in a large scale effectiveness study (examining inputs, outputs and outcomes) based on a sample of children from socially disadvantaged…
- Trial name
- HappyTalk (NCT06460090)
- Testing
- Happy Talk
- Where
- 4 sites in Ireland
- Volunteers
- 840 people
- Sponsor
- University College Cork
Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment and Neuromodulation
This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.
- Trial name
- MCI (NCT07691918)
- Testing
- Low intensity focused ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Polytechnic Institute and State University