Clinical trials: Health of the Human Microbiome
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Metabolic Syndrome
Probiotics and Gut Health
This study evaluates the effects of probiotic consumption on inflammatory outcomes and measures of gut health. Participants will be given yogurt with probiotics for one period and yogurt without probiotics for another, with a…
- Trial name
- PRO (NCT03418857)
- Testing
- Yogurt smoothie with BB-12, Yogurt smoothie
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Penn State University
Health of the Human Microbiome
Dogs as Probiotics
Studies show that family members share as much or more of the composition of their microbiota (the trillions of micro-organisms in our guts) with their dogs as they do with each other (Song et. al. 2013).
- Trial name
- NCT02343731
- Testing
- Introduction of a dog into the home
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Microbial Colonization, Atopic Dermatitis
Nationwide Research on the Rewilding of Kindergarten Yards
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.
- Conditions
- Microbial Colonization, Atopic Dermatitis, Asthma in Children, Allergy
- Trial name
- Vahvistu (NCT06390878)
- Testing
- Biodiversity, Playground equipment
- Where
- 2 sites in Finland
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Inflammatory Bowel Disease, Ulcerative Colitis
Pediatric FEcal Microbiota Transplant for Ulcerative Colitis
The PediFETCh study is a pilot trial designed to assess the feasibility of fecal microbiota transplants for the therapy of pediatric ulcerative colitis (UC) and pediatric inflammatory bowel disease-unclassified (IBD-U).
- Trial name
- PediFETCh (NCT02487238)
- Testing
- Fecal Microbiota Enema, Normal Saline Enema
- Where
- 3 sites in Canada
- Volunteers
- 35 people
- Sponsor
- McMaster Children's Hospital
Healthy Adult Participants
Safety and Efficacy of a Prebiotic Blend in Healthy Humans
The GRASP Trial is a 30-day, randomized, double-blind, placebo-controlled study (Protocol No.: GW-2025-02) designed to evaluate the safety and tolerability of a novel multi-fiber prebiotic blend in healthy adult volunteers (age…
- Trial name
- GRASP (NCT07514741)
- Testing
- Fiber Blend 1 (Low Dose), Fiber Blend 2 (High Dose)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet
Overweight and Obesity
The Alberta FYBER (Feed Your Gut Bacteria morE fibeR) Study
Too much body-fat has been linked to a low-grade inflammation throughout the body. This inflammation is thought to then cause different diseases, like heart disease and diabetes.
- Trial name
- NCT02322112
- Testing
- Microcrystalline Cellulose Supplementation, Acacia Gum Supplementation, Resistant Starch Type 4 Supplementation
- Where
- Canada
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Infantile Colic, Breast Feeding
The Role of Human Milk Oligosaccharides and Microbiomes on Infantile Colic and Atopic Dermatitis in Term Infants
Background: Human milk oligosaccharides (HMO) and microbiota are both key factors for infants to shape the gut flora and develop the immune system.
- Conditions
- Infantile Colic, Breast Feeding, Atopic Dermatitis, Infant Formula
- Trial name
- NCT05992493
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Healthy
The Effect of Functional Dairy Products Enriched With Dietary Fibers on Human Health and Gut Microbiota
The purpose of this dietary intervention is to study the effects of dietary fibers on the gut microbiota and use yoghurt as the carrier. Hypothesis 1: Intake of dietary fibers improves the blood lipid profile of the participants.
- Trial name
- NCT04811157
- Testing
- Test product, Control product
- Where
- Estonia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Center of Food and Fermentation Technologies
Healthy Adults
Adult HMO Supplementation and the Gut Microbiome
The goal of this study is to assess the impact of Layer Origin's SuperHMO prebiotic formulation on the healthy adult gut microbiome.
- Trial name
- NCT06570330
- Testing
- SuperHMO, Non-GMO corn Maltodextrin, Rapid Absorption
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Obesity Prevention, Microbiome Analysis
Effect of Agricultural Practices on Crops, Gut Microbiome, and Human Health
The human gut microbiome plays a regulatory role in host health, and is involved in metabolic, immune, and neurological processes.
- Trial name
- MITA (NCT07165145)
- Testing
- Organic Fruits and Vegetables, Conventional Fruits and Vegetables
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Gut Microbiota
Westlake Gut Microbiome Study
The Westlake Gut Microbiome study is a prospective cohort study. This project aims to characterize the gut microbiome among Chinese populations from different regions of China, and explore the relationships between gut microbiota…
- Trial name
- NCT04435548
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Breast Milk Collection, Human Milk/Breastfeeding
Human Milk and Its Effect on Infant's Metabolism and Infant Gut Microbiome
This protocol explains the MAINHEALTH cohort. The study examine the influence of maternal health parameters on human breast milk composition and integrates milk phenotype with infant metabolism and infant gut microbial content…
- Conditions
- Breast Milk Collection, Human Milk/Breastfeeding, Human Milk Microbiome, Infant Gut Microbiome
- Trial name
- MAINHEALTH (NCT05111990)
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.
In humans and most mammals, bile acids play a role in the metabolism of glucose and the transport and absorption of lipids (such as cholesterol and triglycerides), vitamins, and nutrients by allowing for emulsification (mixing)…
- Trial name
- BioMet-7 (NCT07499414)
- Testing
- 7-KLCA, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy Infants
HMOs on Infant Gut Microbiota Modulation and Development of the Immune System in Healthy Infants
The goal of this clinical trial is to learn how a mixture of human milk oligosaccharides impacts the development of the infant microbiota, the immune maturation and how the interaction between the microbiota and immune maturation…
- Trial name
- BELIEF (NCT06631937)
- Testing
- Human Milk Oligosaccharides
- Where
- 2 sites in Denmark
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gut Microbiome, Healthy Donors
Investigating the Impact of the Seaweed Derived Food Additive, Carrageenan, on the Human Gut Microbiome
The goal of this study is to investigate whether a seaweed derived food additive, carrageenan, has an impact on the human gut microbiome in vivo.
- Trial name
- NCT06738329
- Testing
- Carrageenan gummy sweet, Carrageenan and inulin gummy sweet
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Rheumatoid Arthritis, Parkinson Disease
Deciphering the Impact of Exposures From the Gut Microbiome-derived Molecular Complex in Human Health and Disease
The ExpoBiome project will analyze the impact of fasting on patients with Parkinsons's Disease (PD) or rheumatoid arthritis (RA) on a clinical level as well as the effect of fasting on their immune system and gut microbiota.
- Conditions
- Rheumatoid Arthritis, Parkinson Disease, Healthy
- Trial name
- ExpoBiome (NCT04847011)
- Testing
- Fasting
- Where
- 2 sites in Germany
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Andreas Michalsen
Inflammatory Response
The Effects of Agro-ecological Farming Systems on Human Health
As concerns regarding the effects of agriculture on human and environmental health mount, a growing number of farmers are seeking ways to improve health from the ground up.
- Trial name
- AGROHEALTH (NCT05575258)
- Testing
- 44-Day Diet Conventionally Sourced - YELLOW Diet, 44-Day Diet Agro-Ecologically Sourced - GREEN Diet
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Utah State University