Clinical trials: Healthcare-Associated Infections
Ventilator Adverse Event, Ventilator Associated Pneumonia
Effect of Angulus on Patient-elevation Compliance
Ventilator-associated events (VAE) are a scourge of critical care settings and hospital systems at large. There is extensive evidence that ventilator-associated pneumonia (VAP) and related VAEs increase mortality rates in…
- Conditions
- Ventilator Adverse Event, Ventilator Associated Pneumonia, Hospital Acquired Condition, Hospital-acquired Pneumonia
- Trial name
- NCT03496220
- Testing
- Angulus
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Angulus, LLC
Ventilator Associated Pneumonia, Bacteremia
Intensive Care Unit Acquired Infections in Patients Colonized With Extended Spectrum Enterobacteriaceae
Worldwide emergence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) had become a major problem in ICU, with at least 10% of incidence at the admission in Europe.
- Conditions
- Ventilator Associated Pneumonia, Bacteremia, Abdominal Infection, Enterobacteriaceae Infections
- Trial name
- BMREA (NCT04903886)
- Testing
- observational
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Brest
Community Acquired Pneumonia, Hospital Acquired Pneumonia
The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia
The purpose of the study is to determine if the clinical course of pneumonia is more severe when both, bacterial and viral pathogens are find as possible causative agent and how does it affect treatment.
- Conditions
- Community Acquired Pneumonia, Hospital Acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- SCAHAVAP (NCT02203110)
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Ventilator Associated Pneumonia
Risk Factors and Common Preventive Measures for Ventilator Associated Pneumonia in Patients With Severe Traumatic Brain Injury
The primary objective of this study is to assess the incidence of VAP in patients with TBI and to identify risk factors for developing VAP in this specific patient population (types of co-injuries in patients with multiple trauma…
- Trial name
- NCT03266380
- Testing
- observational
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ventilator-associated Pneumonia
Methods of Chlorhexidine Cleansing to Prevent Ventilator-Associated Pneumonia (VAP)
Ventilator-associated pneumonia (VAP) is common in patients receiving mechanical ventilation, and is associated with longer hospital stay, increased treatment costs, and higher rates of morbidity and mortality .
- Trial name
- VAP (NCT02077920)
- Testing
- Chlorhexidine, 0.9% sodium chloride injection, Endotracheal tube
- Where
- China
- Volunteers
- 192 people
- Sponsor
- General Hospital of Shenyang Military Region
VAP - Ventilator Associated Pneumonia
Performance Study of Targeted Sequencing Technology for VAP
Main purpose: To evaluate the feasibility of tNGS for pathogen detection and drug resistance analysis in VAP patients. Research site and research population: This study is planned to be conducted in hospitals, targeting VAP…
- Trial name
- NCT06035796
- Testing
- tNGS
- Volunteers
- 150 people
- Sponsor
- The First Hospital of Jilin University
Microbial Colonization, Ventilator Associated Pneumonia
Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit
Premature very low birth weight (VLBW) infants are susceptible to complications related to infrequent and non-standardized oral care.
- Trial name
- NCT05167318
- Testing
- frequent standardized oral care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Florida
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Nosocomial Infection, External Causes of Morbidity and Mortality
Tight Glycaemic Control During Cardiac Surgery
To determine whether intraoperative tight glycaemic control can reduce postoperative infection, morbidity and mortality
- Conditions
- Nosocomial Infection, External Causes of Morbidity and Mortality, Hypoglycemia
- Trial name
- TGC (NCT01225159)
- Testing
- TGC, Conventional glycaemic control
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Prince of Songkla University
ICU Patients Requiring a Central Venous Access
Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection
The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions.
- Trial name
- NCT00259350
- Testing
- Skin disinfection
- Where
- France
- Volunteers
- 520 people
- Sponsor
- Poitiers University Hospital
Hospital-acquired Pneumonia
Trial on a Strategy Combining Rapid Diagnostic Testing and Antimicrobial Stewardship to Improve Antibiotic Use in Patients With Hospital-acquired Pneumonia.
Hospital-Acquired Pneumonia (HAP) is the second most frequent hospital-acquired infection in the US and Europe and accounts for a large proportion of antibiotics prescribed in hospitals.
- Trial name
- SHARP (NCT04153682)
- Testing
- Rapid Diagnostic Testing, Antimicrobial stewardship
- Where
- 8 sites in France
- Volunteers
- 116 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness
The Energy Dose Study
The investigators have designed this single-center Randomized Clinical Trial (RCT) to prospectively compare, for the first time, the clinical efficacy of different energy doses in intensive care unit (ICU) patients requiring…
- Trial name
- NCT01369147
- Testing
- Parenteral Nutrition, Propofol, Clevidipine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Hospitalized Children With Suspected or Confirmed Nosocomial Pneumonia
Single-dose PK Study of Ceftazidime-Avibactam In Hospitalized Children Receiving Systemic Antibiotics for Nosocomial Pneumonia
This is a multicenter, multinational, open label single dose pharmacokinetic (PK) study enrolling at least 32 subjects. The study aims to characterize the pharmacokinetics (PK) of a single intravenous dose of CAZ AVI in pediatric…
- Trial name
- NCT04040621
- Testing
- Ceftazidime-avibactam
- Where
- 4 sites in China, Taiwan
- Volunteers
- 4 people
- Sponsor
- Pfizer
Healthcare Associated Infection, Multidrug Resistant Organisms
Ultra Violet-C Light Evaluation as an Adjunct to Removing Multi-Drug Resistant Organisms (UVCLEAR-MDRO)
This study examines the impact of UV-C light disinfection as an adjunct to routine daily and discharge patient room cleaning on patient infection and colonization with hospital associated bacteria.
- Trial name
- UVCLEAR-MDRO (NCT02605499)
- Testing
- UV-C light disinfection
- Volunteers
- 83 people
- Sponsor
- Johns Hopkins University
Nosocomial Infections
Multi-center Observational Study to Evaluate Epidemiology and Resistance Patterns of Common ICU-Infections (MOSER)
Most literature on ICU infections and the resistant patterns comes from the western literature. This data may not truly reflect the incidence, epidemiology and resistance patterns in developing countries such as India.
- Trial name
- MOSER (NCT01346735)
- Testing
- No intervention
- Where
- India
- Volunteers
- 381 people
- Sponsor
- Indian Society of Critical Care Medicine
Candida Auris Infection, Candida Auris Colonization
Evaluation of Rapid Diagnostic Device for the Detection of Candida Auris
"Candida auris is an emerging fungus that can cause severe infections, particularly in hospitalized patients, and is often resistant to multiple antifungal treatments.
- Conditions
- Candida Auris Infection, Candida Auris Colonization, Nosocomial Infections
- Trial name
- DiagRaMIE Caur (NCT07253311)
- Testing
- NG-TestⓇ C.auris kit
- Where
- Greece
- Volunteers
- 554 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carbapenemase-Producing Enterobacteriaceae (CPE), Healthcare-Associated Infections (HAIs)
Effect of Daily Chlorhexidine Bathing and Antibiotic/PPI Stewardship on Prevention of CPE Transmission and Infection
This multicenter, cluster-randomized crossover trial aims to evaluate the effectiveness and safety of a bundled intervention-including daily chlorhexidine bathing and targeted antimicrobial and proton pump inhibitor (PPI)…
- Trial name
- NCT07039955
- Testing
- Daily Chlorhexidine Bathing, Antimicrobial and PPI Stewardship Program, Standard Bathing
- Where
- 3 sites in South Korea
- Volunteers
- 5,760 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Ventilator-Associated Pneumonia
Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia
The proposed study will evaluate adult patients admitted to the medical or surgical intensive care units (ICUs) at San Francisco General Hospital (SFGH).
- Trial name
- NCT00319644
- Testing
- Bronchoalveolar lavage
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, San Francisco
Hand Hygiene Training, Infection Prevention and Control
Effectiveness of an Edge AI-based Augmented Reality System for Hand Hygiene Training: a Multi-centre, Mixed-methods Cluster Randomised Controlled Trial
This multi-centre, mixed-methods cluster randomised controlled trial (cRCT) aims to evaluate the effectiveness of an edge artificial intelligence (AI)-based augmented reality (AR) training and assessment system for improving hand…
- Conditions
- Hand Hygiene Training, Infection Prevention and Control, Healthcare-Associated Infections (HAIs), Health Education
- Trial name
- HANDHEART (NCT07280026)
- Testing
- Instructional Video + Scanner Feedback, Edge AI-based AR Hand Hygiene Training System
- Where
- 3 sites in China, Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Probiotic, Ventilator Associated Pneumonia
Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit
The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
- Conditions
- Probiotic, Ventilator Associated Pneumonia, Critically- Ill Children
- Trial name
- NCT07848165
- Testing
- Probiotics, Standard management
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University