Clinical trials: Healthy Adult
Healthy
A Study of Four Different Oral Tablet Formulations of Lazertinib (JNJ-73841937) in Healthy Adult Participants
The purpose of this study is to assess the bioequivalence of four different lazertinib oral tablet formulations in healthy adult participants under fasted condition.
- Trial name
- NCT05742594
- Testing
- Lazertinib
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Volunteers
A Single and Multiple-Ascending Dose Study of CRN01941 in Healthy Adult Volunteers
This is a Phase 1, double-blind, randomized, placebo-controlled, single-dose and multiple-dose study of CRN01941 in up to 119 healthy male and female subjects.
- Trial name
- NCT03936166
- Testing
- CRN01941 Oral Solution, CRN01941 Oral Capsule
- Where
- Australia
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Crinetics Pharmaceuticals Inc.
Healthy Aging, Physical Fitness
Effects of Core Stability Training Using Pilates on Core Muscle Strength, Pulmonary Function, and Cardio-respiratory Fitness in the Elderly.
This study investigates how different types of exercise-specifically Mat Pilates and Aerobic training-can help improve the physical health and breathing capacity of healthy older adults aged 60 to 77.
- Conditions
- Healthy Aging, Physical Fitness, Core Stability, Respiratory Function
- Trial name
- PLT-AER-ELD (NCT07470060)
- Testing
- Mat Pilates Program, Aerobic Exercise (Treadmill Walking)
- Where
- Thailand
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Walailak University
Healthy
Study Evaluating The Potential Effect Of Multiple Doses Of Neratinib On The Pharmacokinetics Of A Single Dose Of Digoxin
The purpose of this study is to evaluate the potential effect of multiple doses of neratinib on the pharmacokinetics (how the body absorbs, distributes, metabolizes and/or excretes) of a single dose of digoxin.
- Trial name
- NCT00860223
- Testing
- Digoxin, Neratinib
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Puma Biotechnology, Inc.
Cutaneous Leishmaniasis
Study to Evaluate the Leish-111f + MPL-SE Vaccine in Healthy Adults Not Previously Exposed to Leishmania Parasite
This study will evaluate the safety and immunogenicity of the Leish-111f + MPL-SE vaccine in adult subjects who have no evidence of previous exposure to the Leishmania parasite.
- Trial name
- NCT00121862
- Testing
- Leish-111f + MPL-SE vaccine
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Access to Advanced Health Institute (AAHI)
Cyclists, Healthy Adult Male
The Effects of Beta-Alanine Supplementation on Mechanical Performance, Acid-Base Balance, Oxidative Stress, and Enzymatic Antioxidant Defence During Repeated Wingate Anaerobic Tests Under Normoxic and Hypoxic Conditions
Beta-alanine is a dietary supplement that increases skeletal muscle carnosine concentration and may enhance the muscle's ability to buffer hydrogen ions produced during high-intensity exercise.
- Trial name
- NCT07650162
- Testing
- beta-alanine, normoxic conditions, Normobaric hypoxic conditions (≈2500 m)
- Where
- Poland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Chikungunya Virus Infection
Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults
This is a multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety and immunogenicity of a 2-injection vaccine Chikungunya virus (CHIKV) virus-like particle vaccine (CHIKV VLP) in healthy adults.
- Trial name
- NCT02562482
- Testing
- VRC-CHKVLP059-00-VP, VRC-PBSPLA043-00-VP
- Where
- 6 sites in Dominican Republic, Guadeloupe and 3 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pulmonary Disease, Chronic Obstructive, Healthy
Low Load, High-repetitive Elastic Band Resistance Training in COPD
Recent work have shown that low load, high-repetitive single limb resistance training, if compared to a control, can increase limb muscle function and functional exercise capacity in patients with chronic obstructive pulmonary…
- Trial name
- NCT02283580
- Testing
- Single limb, Two limb
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laval University
Healthy Subjects, Infection, Human Immunodeficiency Virus
DDI Study of Etravirine and GSK1265744
The primary objective of this study is to compare steady-state plasma PK, safety and tolerability of GSK1265744 with and without etravirine
- Trial name
- NCT00920296
- Testing
- GSK1265744
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion
The purpose of this study is to assess the relative potency of multiple oral doses of LUM001 and SHP626 administered for 7 days as assessed by fecal bile acid excretion in overweight and obese adult subjects.
- Trial name
- NCT02475317
- Testing
- Maralixibat, Volixibat
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mirum Pharmaceuticals, Inc.
Tuberculosis
Safety Study of ChAdOx1 85A Vaccination With and Without MVA85A Boost in Healthy Adults
This is a Phase I trial to evaluate the safety and immunogenicity of a ChAdOx1 85A vaccination with and without MVA85A boost in healthy BCG vaccinated adults.
- Trial name
- NCT01829490
- Testing
- ChAdOx1 85A, MVA85A
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Muscle Metabolism
The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis
Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but…
- Trial name
- NCT06129513
- Testing
- Bilateral resistance exercise, Whey protein, Plant-blend protein
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy
Study of Oral ALXN1840 at 2 Dose Strengths in Healthy Adults
To assess the relative bioavailability of ALXN1840 administered orally as a single enteric-coated (EC) tablet (reference, Treatment A) versus three EC tablets (test, Treatment B).
- Trial name
- NCT05303324
- Testing
- ALXN1840
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Overweight (BMI > 25), Obese But Otherwise Healthy Participants
Pistachio Snacking and Metabolic Flexibility
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults.
- Conditions
- Overweight (BMI > 25), Obese But Otherwise Healthy Participants, Overweight or Obese, Obese Patients (BMI ≥ 30 kg/m²)
- Trial name
- NCT07340125
- Testing
- Pistachio
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Pharmacokinetics
Nicotine Pharmacokinetics and Pharmacodynamics, Safety and Tolerability of P3P
This is a single-center, open-label, randomized, crossover study to evaluate the pharmacokinetic (PK) profiles of four P3P variants (differing in nicotine aerosol particle size, nicotine concentration and in the absence or…
- Trial name
- NCT03369340
- Testing
- P3P 1, P3P 2, P3P 3
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Healthy, Pharmacokinetics of Quetiapine
Study to Evaluate the Effect of Multiple-dose of Fluvoxamine on the Plasma Concentration of Quetiapine (FK949E) in Healthy Male Volunteers
The objective of the study was to assess the effect of multiple-dose fluvoxamine on the pharmacokinetics of quetiapine (FK949E) in healthy adult male subjects. The safety of FK949E in the population was also evaluated.
- Trial name
- NCT01908296
- Testing
- FK949E, fluvoxamine
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Pain
A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation and Strength of Suzetrigine
The purpose of this study is to evaluate the pharmacokinetics (PK) of suzetrigine (SUZ; VX-548) and its metabolite along with its safety and tolerability, in healthy participants.
- Trial name
- NCT06336096
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of ABBV-277 in Healthy Adult Participants
The objective of this study is to evaluate the safety, tolerability, immunogenicity and pharmacokinetics (PK ) properties following a single dose of ABBV-277 in healthy adult participants.
- Trial name
- NCT07136103
- Testing
- ABBV-277
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy Adults, Exercise Self-Efficacy
Turkish Version of the BARSE
Background Physical inactivity is known to rank fourth among modifiable mortality risk factors globally and plays a central role in the etiology of noncommunicable diseases.
- Conditions
- Healthy Adults, Exercise Self-Efficacy, Validation Studies
- Trial name
- BARSE-Turkish (NCT07850661)
- Testing
- Questionnaire Administration
- Where
- Turkey (Türkiye)
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Hypertension and Dyslipidemia
A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-348
A Clinical Trial to evaluate the Pharmacokinetics and Tolerability of CKD-348
- Trial name
- CKD-348 (NCT04660370)
- Testing
- CKD-348, CKD-828, D097, D337
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
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