Clinical trials: Healthy Elderly
COVID-19
A Clinical Trial to Evaluate the Recombinant SARS-CoV-2 Vaccine (CHO Cell) for COVID-19
phase I study will evaluate safety and immunogenicity of a recombinant SARS-CoV-2 vaccine (CHO cell) in Chinese healthy population aged 3 years and older.
- Trial name
- NCT04869592
- Testing
- low-dose Recombinant SARS-CoV-2 Vaccine (CHO cell), high-dose Recombinant SARS-CoV-2 Vaccine (CHO cell)
- Where
- China
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- National Vaccine and Serum Institute, China
Cough, Parkinson's Disease
Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the chest and lungs.
- Trial name
- NCT02183519
- Testing
- Capsaicin, Voluntary cough test
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Ageing
Vasopressin in the Elderly: Physiological Changes in Neuroendocrine Function and Urinary Secretion in Healthy Aging
Elderly people are at a high risk for disturbances in water homeostasis, with both hypo- and hypernatremia being more common with increasing age.
- Trial name
- VENUS (NCT06930300)
- Testing
- Hypertonic 3% saline, Water
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Alzheimer Disease
Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of Oral ASN51 in Healthy Subjects and Subjects With Alzheimer's Disease
ASN51-101 is a randomized, double-blind, placebo-controlled, phase 1 first in human (FIH) safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) study of oral ASN51 in healthy young adult and elderly subjects and…
- Trial name
- NCT04759365
- Testing
- ASN51
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Asceneuron Pty Ltd.
Influenza
A Clinical Trial of an Quadrivalent Inactivated Influenza Vaccine in Healthy Children Aged 6 to 35 Months
In this single-center, randomized, blinded, positive-controlled design, the investigators will assess the safety and immunogenicity of 2 doses of an inactivated quadrivalent influenza vaccine in children aged 6 to 35 months.
- Trial name
- NCT05212623
- Testing
- quadrivalent influenza split vaccine, Influenza virus split vaccine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Functional Fitness, Cognitive Abilities
High-Intensity Exercise in Older Adults
The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were: 1.
- Trial name
- NCT06199661
- Testing
- APEX
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
COPD
Casein Protein and Leucine Supplementation in Chronic Obstructive Pulmonary Disease (COPD)
Weight loss commonly occurs in patients with COPD, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01734473
- Testing
- Hydrolyzed casein protein, Hydrolyzed casein protein + carbohydrates, Hydrolyzed casein protein + leucine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Healthy
REMINDer - A Digital Environmental Enrichment Intervention
The primary goal of this pilot study is to assess the feasibility and effectiveness for improving overall mental and physical well-being of a multimodal intervention program in older adults carried out in a digital telehealth…
- Trial name
- REMINDer (NCT06530277)
- Testing
- REMINDer (A digital environmental enrichment intervention)
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Clostridium Difficile Associated Disease
Clostridium Difficile Vaccine Safety, Tolerability, and Immunogenicity Study in Japanese Adults
The first-in-Japanese study B5091010 has been designed to evaluate the safety, tolerability, and immunogenicity of 2 antigen dose levels of C difficile vaccine when administered as one of two 3-dose regimens to healthy Japanese…
- Trial name
- NCT02725437
- Testing
- Clostridium difficile Vaccine
- Where
- 2 sites in Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pfizer
Motivation in Healthy Older Adults
Frontopolar Cortex and Motivation in Healthy Older Adults
Motivation represents a core aspect of goal-directed behavior as it determines how much effort individuals are willing to invest to reach their goals.
- Trial name
- NCT03197181
- Testing
- transcranial direct current stimulation
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obesity, Insulin Resistance
A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity
Type 2 diabetes is a major public health problem in India with an estimated a prevalence of approximately 4% and 12% in rural and urban areas respectively.
- Trial name
- LongtermVitD (NCT01052181)
- Testing
- Cholecalciferol
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dr Jitender Nagpal
Aging
Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults
Decline in brain health and associated loss of cognitive function in healthy aging decreases quality of life.We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it…
- Trial name
- NCT04276805
- Testing
- Transcutaneous vagal nerve stimulation (tVNS), Cognitive training
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Infectious Disease, COVID-19
Safety and Immunogenicity of RVM-V001 in Healthy Individuals Previously Vaccinated With BNT162b2 and mRNA-1273
Phase 1, open-label, dose-escalation study to evaluate the safety, tolerability, and immunogenicity of RVM-V001 administered as a single intramuscular injection in healthy adults.
- Trial name
- NCT05420077
- Testing
- RVM-V001 10 µg, RVM-V001 30 µg, RVM-V001 60 µg
- Where
- 2 sites in Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- RVAC Medicines (US), Inc.
Healthy Young Adults, Prefrail Elderly
GOS and Microbial Fermentation in Aging
The population is aging worldwide, concomitant frailty is increased in older age groups. Frailty has a strong impact on outcomes of multi-morbidity and daily living, thereby negatively influencing quality of life and health care…
- Trial name
- NCT03077529
- Testing
- Galacto-oligosacchride, Maltodextrin
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Aging
Effects of Brisk Walk With Low Intensity in Elderly
The goal of this clinical trial is to compare the effects of brisk walk with low intensity aerobic exercises on flexibility balance muscle endurance and life satisfaction in healthy elderly population.
- Trial name
- NCT05751083
- Testing
- brisk walk+ low intensity aerobic exercises, Brisk walk
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Heart Failure
A Study to Learn About the Taste of Vericiguat Given in Liquid Form in Healthy Male Participants Aged 18 to 45 Years
Heart failure is a condition in which the heart does not pump blood as well as it should. It can happen in both adults and children.
- Trial name
- NCT06474208
- Testing
- Formulation 1, Formulation 2, Formulation 3
- Where
- Germany
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bayer
Exercise, Self Efficacy
Social Media Chatbot on Physical Activity Education for Older Adults
In this study, a social media chatbot was used to provide a continuous and real-time multimedia health education program on physical activity for the older adults, as well as supportive messages and feedbacks, to improve physical…
- Conditions
- Exercise, Self Efficacy, Behavioral Regulation, Healthy Aging
- Trial name
- NCT06423040
- Testing
- Social Media Chatbot on Physical Activity Education
- Where
- Taiwan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Aged, Aged Healthy Volunteer
Robotic-Assisted System in Enhancing Balance, Postural Stability, Functional Gait and Fall Efficacy in Older Adults
Our study aims to investigate the effectiveness of a more individualized and personalized feedback-oriented approach using a Robotic Assisted System, the Hunova Movendo Robotic System.
- Conditions
- Aged, Aged Healthy Volunteer, Geriatric, Balance
- Trial name
- ROB-BST (NCT06973460)
- Testing
- Robotic Assisted System, Otago Exercise Programme
- Where
- United Arab Emirates
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Healthy Aging
Online Grammatical Reasoning Training for Older Adults
The START study will investigate the impact of playing a Grammatical Reasoning brain training task on overall brain function (cognition) and day-to-day function in people over 50. .
- Trial name
- START (NCT03661190)
- Testing
- Grammatical Reasoning, Card Pairs
- Where
- United Kingdom
- Volunteers
- 6,544 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Virus Diseases, Respiratory Tract Diseases
Basic and Clinical Research on Applying Blood Fix to Treat Critical H1N1 Patients
The 2009 flu pandemic is a global outbreak of a new strain of influenza A virus subtype H1N1, commonly known as swine flu, that was first identified in April 2009.
- Conditions
- Virus Diseases, Respiratory Tract Diseases, Respiratory Tract Infections, Influenza
- Trial name
- NCT01055990
- Testing
- split-virion, non-adjuvanted H1N1 vaccine of 15 μg, blood fix
- Where
- China
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Shanghai Public Health Clinical Center
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