Clinical trials: Healthy Normal Weight
Healthy, Normal Weight
Childhood Metabolic Markers of Adult Morbidity in Blacks
Blacks are at increased risk for obesity, type 2 diabetes mellitus and cardiovascular disease. A common pathogenetic link among these entities is insulin resistance/hyperinsulinemia.
- Conditions
- Healthy, Normal Weight, Overweight
- Trial name
- NCT01312051
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Immune System Tolerance, Depression
ESAN II - Energy Sensing in Depression
The purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Immune System Tolerance, Depression, Obesity, Microbial Colonization
- Trial name
- NCT05432362
- Testing
- Aronia Juice
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Obesity
A Research Study Investigating Safety and Concentration in the Blood After One Dose Tablet of the New Medicine Monlunabant in Healthy Weight Japanese and Caucasian Men
The study is testing a new study drug in healthy normal weight Japanese and Caucasian participants after a single dose. The aim of this study is to see if the new medicine is safe and how it works in the participants body.
- Trial name
- NCT06542536
- Testing
- Monlunabant
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy
Secondary Analysis of Gut Hormones and Inflammatory Cytokines in Fasting Subjects
The original study executed between 2002-2004 was an interventional trial in which 20, healthy, normal-weight female subjects were randomized to a four-day fast plus daily subcutaneous injections of leptin or a four day fast plus…
- Trial name
- NCT01257841
- Testing
- Leptin administration, Fasting
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy, Glucose Metabolism Disorders
Energy Metabolism and Acute Effects of Protein Diets in Metabolically Obese Normal Weight Individuals
Asians tend to develop type 2 diabetes (T2D) at lower body mass index (BMI) levels and younger ages compared to other populations.
- Conditions
- Healthy, Glucose Metabolism Disorders, Obesity, Visceral, Obesity; Endocrine
- Trial name
- MONW (NCT06802341)
- Testing
- Normal protein diet, Animal protein diet, Plant based diet
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Adipose Tissue
Effect of Obesity on Extracellular Matrix Composition
The experiment is a simple cross-sectional study with three groups (n=10) in each group, young and old healthy men and obese young men. The study will investigate the composition of the adipose tissue extra cellular matrix.
- Trial name
- EOBECM (NCT06304506)
- Testing
- Cross sectional study
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Rheumatoid Arthritis, Healthy
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
This study has two phases. Phase 1 will examine the role of inflammatory mediators called cytokines on growth hormone levels in women with rheumatoid arthritis (RA).
- Trial name
- NCT00034060
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type2 Diabetes, Obesity
Glucose Metabolism in Brown Adipose Tissue (BAT) in Young Healthy Men Evaluated by Deuterium Metabolic Imaging (DMI)
In this study the investigators wish to evaluate the glucose metabolism in brown adipose tissue (BAT) in young healthy men (aged 18-35).
- Conditions
- Type2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT04060745
- Testing
- cooling using a water-perfused vest, thermoneutrality
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Volunteers
Influence of Intragastric Fatty Acid Infusion on Behavioral Responses to Positive Emotion Induction in Healthy Subjects
The purpose of this study is to test whether intragastrically infused fatty acid will interact with positive emotion induction and if this effect is mediated by gut hormones.
- Trial name
- NCT02982616
- Testing
- Dodecanoic acid, Positive emotion, saline
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rheumatoid Arthritis
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567.
A study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of AZD9567.
- Trial name
- NCT02760316
- Testing
- AZD9567 10 mg, AZD9567 20 mg, AZD9567 40 mg
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity, Normal Weigth
Comparative Analysis of Postprandial Effects in Healthy and Obese Individuals
After eating, blood composition changes, including increased triglycerides and glucose, which can trigger postprandial inflammation. Particularly with high-fat foods, pro-inflammatory lipopolysaccharide (LPS) increases.
- Trial name
- CAPE (NCT06645756)
- Testing
- Test meal
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Obesity
Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity
This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing…
- Trial name
- NCT01900366
- Testing
- Fat Biopsy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity, Normal Physiology
Energy Expenditure Responses to Different Temperatures
Background: The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm.
- Trial name
- NCT01568671
- Testing
- Room temperatures
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Volunteers
Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects
The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.
- Trial name
- NCT02212821
- Testing
- Erythromycin
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity, Diabetes
Study of the Mechanisms of Metabolic Adaptations to Overfeeding
Obesity results from complex interactions between genetic and environmental factors, and are strongly associated with metabolic complications such as type 2 diabetes mellitus.
- Trial name
- Polynut (NCT02225457)
- Testing
- Hypercaloric diet, polyphenols
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy, Obesity
A Study of Adipose Tissue in Adaptive Responses to Exercise
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
- Trial name
- NCT06053125
- Testing
- Adipose Tissue Biopsy, Exercise
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
The Effects of Acute Weight Gain and Acute Calorie Deprivation on Marrow Adipose Tissue
Marrow adipocytes have been identified as a component of the bone marrow micro-environment. Evidence exists suggesting that marrow fat plays an important physiologic role in both bone mineral and energy metabolism in humans.
- Trial name
- NCT02482519
- Testing
- High calorie diet, Fasting
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Insulin Resistance
Vitamin D Supplementation and Glycemic Outcomes
The investigators examined the effect of vitamin D supplementation on glucose homeostasis and metabolic markers in healthy normal weight and overweight young subjects and healthy normal-weight and overweight elderly subjects…
- Trial name
- NCT02942732
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université d'Auvergne
Healthy
Effect of Garlic on Inflammatory Mediators
This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.
- Trial name
- NCT00275405
- Testing
- Garlic Oil Macerate
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Obesity
Mirabegron and Brown Adipose Tissue
Obesity and type 2 diabetes (T2D) are emerging problems worldwide. In particular South Asian individuals (representing 20% of the world population) have an increased risk of obesity and related disorders.
- Trial name
- Mirab (NCT03012113)
- Testing
- Mirabegron, Short term mild cooling
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet