Clinical trials: Healthy Older Adults
Cognitive Ability, General, Brain Health
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65…
- Conditions
- Cognitive Ability, General, Brain Health, Cerebral Oxygenation
- Trial name
- HYPOX-AGE (NCT06874387)
- Testing
- Hypoxia, intermittent, physical exercise
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ayoub Boulares
Healthy Ageing
Vasopressin in the Elderly: Physiological Changes in Neuroendocrine Function and Urinary Secretion in Healthy Aging
Elderly people are at a high risk for disturbances in water homeostasis, with both hypo- and hypernatremia being more common with increasing age.
- Trial name
- VENUS (NCT06930300)
- Testing
- Hypertonic 3% saline, Water
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Aging, Overweight and Obesity
Postprandial Inflammation and Nuts (PIN) in Older Adults
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group.
- Trial name
- PIN (NCT06348771)
- Testing
- monounsaturated fatty acids (MUFA) peanut meal
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Herpes Zoster, Herpes Zoster Vaccine
Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell) in Healthy Chinese Population Aged 40 Years and Older
The objective of this study was to evaluate the safety, immunogenicity and immune persistence of recombinant herpes zoster vaccine (CHO cells) with different adjuvant doses in healthy people aged 40 years and older.
- Trial name
- NCT06851832
- Testing
- Recombinant zoster vaccine(CHO cell)(low adjuvant), Recombinant Zoster Vaccine (CHO cell), Zoster Vaccine, Live
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Ab&B Bio-tech Co., Ltd.JS
Healthy
Study to Investigate Safety, Tolerability and Pharmacokinetics With Single and Multiple Ascending Doses of AZD1446
This study is designed to evaluate the safety, tolerability and PK of AZD1446 in Subjects when given as multiple dose administration for either 7 Days (Day 1 single dose, Day 2-6 multiple doses) in Part A and optionally at…
- Trial name
- NCT00902993
- Testing
- AZD1446
- Where
- 2 sites in Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Infections, Papillomavirus
A Study to Evaluate the Immunogenicity and Safety of GSK Biologicals' HPV Vaccine in Healthy Women Aged 18-35 Years
Human papillomavirus infection has clearly been recognized as the cause of cervical cancer. Indeed, the infection of the cervix by certain oncogenic types of HPV, if not cleared , can lead over time to cervical cancer in women .
- Trial name
- NCT00306241
- Testing
- HPV-16/18 L1 VLP AS04
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers (Middle-aged Smokers)
Effects of Curcumin on Vascular Reactivity
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
- Trial name
- CURCUMIN (NCT01543386)
- Testing
- Curcumin
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Pain
A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of AMG 403 in Healthy Subject
This study is to evaluate the safety of AMG 403 in healthy adult subjects. The study consists of a 21 day screening period followed by administration of the investigational product and up to 154 day evaluation period.
- Trial name
- NCT02348879
- Testing
- AMG 403
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Amgen
Healthy Subjects
Effect of Tai Chi Chuan on Autonomic Nervous Modulation in Aged Subjects
Since Tai Chi Chuan (TCC) training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and…
- Trial name
- NCT00745303
- Testing
- Tai Chi Cuan
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy Older Adults
Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults
The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease.
- Trial name
- NCT07649005
- Testing
- low sodium/low potassium diet, high sodium/low potassium diet, high sodium/high potassium diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cognitive Decline, Healthy
The Effects of Attentional Filter Training on Working Memory
The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional…
- Conditions
- Cognitive Decline, Healthy, Age-related Cognitive Decline
- Trial name
- DIIN (NCT03228446)
- Testing
- filter training, memory training, no training (control)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Sarcopenia, Eldery People
Earlier Elderly People in Urban Areas
Social innovation in aging needs to bring new ideas and services to meet new social and welfare needs identified in recent years.
- Conditions
- Sarcopenia, Eldery People, Lifestyle, Healthy, Nutrition
- Trial name
- NCT05268146
- Testing
- Lifestyles
- Where
- 2 sites in Spain
- Volunteers
- 77 people
- Sponsor
- University Rovira i Virgili
Influenza
Safety and Immunogenicity of Two 0.25 mL or 0.5 mL Doses of Two Different Influenza Vaccines in Healthy Children Aged 6 to <60 Months
This a multicenter phase II trial will evaluate safety and immunogenicity of two 0.25 mL or 0.5 mL doses of investigational influenza vaccine and active control influenza vaccine in healthy children aged 6 to <60 months.
- Trial name
- NCT00649883
- Testing
- Influenza Trivalent Inactivated vaccines Novartis, Influenza Trivalent Inactivated vaccines
- Where
- 5 sites in Guatemala
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Novartis
Human Papillomavirus Infection
Long-term Immune Persistence of a Bivalent HPV Vaccine in Females From Study 311-HPV-1004
This long-term extension study evaluates the persistence of neutralizing antibody responses to a bivalent human papillomavirus vaccine in females who previously participated in study 311-HPV-1004 (NCT02740777).
- Trial name
- NCT07820241
- Testing
- Bivalent Human Papillomavirus Vaccine (Types 16 and 18, Pichia pastoris)
- Where
- 2 sites in China
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Aging, Healthy, Risk Reduction
The REMINDER Program for Older Adults Supported by Residential and Daycare Facilities
Dementia and mild cognitive impairment (MCI) deeply impact individuals' well-being and are expected to increase due to population aging, with global cases projected to rise to 152.8 million by 2050.
- Conditions
- Aging, Healthy, Risk Reduction, Old Age; Dementia
- Trial name
- REMINDER (NCT06733181)
- Testing
- REMINDER intervention
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Healthy
Effects of Qigong, Tai Chi and Yoga Practice in Older Adults
The purpose of this study is to compare the effects of an 8-week intervention using YiRen Qigong, Tai Chi or Hatha yoga in older adults (age 70 and above) residing at a Gencare senior living facility.
- Trial name
- NCT00710853
- Testing
- YiRen Qi gong, Tai Chi, Hatha yoga
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Healthy
Correlation of 6-Minute Walk Test and Neuromuscular Parameters in the Elderly
The six-minute walk test had been used to assessment the cardiopulmonary parameter in patients with lung and heart disease. And it has good reliability and validity.
- Trial name
- NCT00451737
- Testing
- Isokinetic test
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
COVID-19 Pandemic, Vaccine Reaction
UNAIR Inactivated COVID-19 Vaccine
This is a randomized, observer blind, controlled phase I/II study to evaluate the Safety, Reactogenicity, and Immunogenicity of UNAIR Inactivated Covid-19 Vaccine in Healthy Populations Aged 18 Years and Above.
- Trial name
- NCT05226429
- Testing
- UNAIR Inactivated COVID-19 Vaccine, CoronaVac Biofarma COVID-19 Vaccine
- Where
- Indonesia
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
Healthy Females, Protein Requirement
Determination of Protein Requirements in Elderly Female Subjects >75 Yrs Old
Minimal data are available on protein requirements throughout the lifespan. Currently available recommendations are based on nitrogen balance data. The limitations of the nitrogen balance method have been well described.
- Trial name
- NCT01604980
- Testing
- Protein intake.
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Rabies
A Phase 3 Clinical Trial for a Rabies Vaccine (Vero Cell) for Human Use in Healthy Chinese Subjects
The purpose of this single-centre, randomized, double-blind, parallel control, phase 3 study is to evaluate the safety and immunogenicity of a rabies vaccine (Vero Cell) for human use in healthy Chinese subjects aged 10-60 years…
- Trial name
- NCT02491541
- Testing
- Changchun Werersai, Jilin Maifeng
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
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