Clinical trials: Heart; Complications
Neoplasms, Pulmonary Disease, Chronic Obstructive
Outlook: An Intervention to Improve Quality of Life in Serious Illness
This study will demonstrate whether an end-of-life preparation and completion intervention reduces anxiety, depression, pain and other symptoms and improves functional status, spiritual well-being, and quality of life.
- Conditions
- Neoplasms, Pulmonary Disease, Chronic Obstructive, Heart Failure, Renal Disease
- Trial name
- NCT00939146
- Testing
- Outlook Attention Control, Outlook Intervention
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Duke University
Coronary Artery Bypass
Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery
Blood glucose levels increase in response to stress, infection or other conditions faced by patients in the hospital. This occurs commonly among patients with known diabetes, but also among non-diabetic hospitalized patients.
- Trial name
- NCT00394303
- Testing
- Intraoperative continuous insulin infusion, Control
- Where
- Israel
- Volunteers
- 1,400 people
- Sponsor
- Rabin Medical Center
Breast Cancer Female, Acute Coronary Events
Implications of MEDIcal Low Dose RADiation Exposure - BReast Cancer Acute Coronary Events
MEDIRAD-BRACE aims to determine the relationship between 3D dose distributions in cardiac structures and the risk of acute coronary events (ACE) and other cardiac complications in breast cancer (BC) patients to develop and…
- Conditions
- Breast Cancer Female, Acute Coronary Events, Cardiac Complications
- Trial name
- MEDIRAD-BRACE (NCT03211442)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 7,000 people
- Sponsor
- University Medical Center Groningen
Myocardial Reperfusion Injury
Post Cond No Reflow
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of…
- Trial name
- NCT01208727
- Testing
- postconditioning
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injuries, Kidney Injuries, Acute
Short Term Spironolactone for Prevention of Acute Kidney Injury After Cardiac Surgery
Our aim is to test whether short term perioperative administration of oral spironolactone could reduce incidence of postoperative acute kidney injury (AKI) in cardiac surgical patients.
- Conditions
- Acute Kidney Injuries, Kidney Injuries, Acute, Kidney Injury, Acute, Acute Renal Injury
- Trial name
- NCT02417896
- Testing
- Spironolactone
- Where
- 2 sites in Mexico
- Volunteers
- 150 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Cancer, Sequels
Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood
The SALTO-SNA study is an ancillary study of the SALTO study (Suivi À Long Terme en Oncologie des enfants guéris d'un cancer pédiatrique en régions Rhône-Alpes et Auvergne) coordinated by Dr.
- Conditions
- Cancer, Sequels, Complications, Autonomic Nervous System
- Trial name
- SALTO-SNA (NCT01574196)
- Testing
- Autonomic nervous system activity records
- Where
- 4 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Eye Abnormalities, Arrythmia
Relation Between Oculocardiac Reflex and Laryngospasm
The aim of this study is to evaluate whether there is a significant relation between various arrhythmias during the surgeon's stretching the eye muscles and laryngospasm and emergence agitation in strabismus surgeries
- Trial name
- NCT05339880
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University
Cardiovascular Complication
RDW to Platlet Count Ratio in CKD Patients
The aim of the study is to determine Red blood cell distribution width to platelet count ratio as a predictor of cardiovascular complications in CKD patients
- Trial name
- NCT05754827
- Testing
- RDW to platlet count ratio
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Kidney Transplantation, Acute Kidney Tubular Necrosis
Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant.
This study is designed to investigate whether allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) can promote function recovery in patients with poor early graft function after kidney transplantation from Chinese…
- Trial name
- NCT02563366
- Testing
- BM-MSCs, Saline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Myocardial Infarction, Coronary Revascularization
Transfusion Trigger After Operations in High Cardiac Risk Patients
The goal of the proposed study is to determine whether a liberal transfusion strategy (transfusion trigger at Hb < 10 gm/dl) in Veterans at high cardiac risk who undergo major open vascular and general surgery operations is…
- Conditions
- Myocardial Infarction, Coronary Revascularization, Acute Renal Failure
- Trial name
- TOP (NCT03229941)
- Testing
- Blood Transfusion
- Where
- 16 sites in United States
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Kidney Injury
A Study to Evaluate Efficacy and Safety of QPI-1002 for Prevention of Acute Kidney Injury Following Cardiac Surgery
This trial is designed to evaluate QPI-1002 versus placebo for the prevention of AKI in subjects who are at high risk for AKI following cardiac surgery.
- Trial name
- NCT02610283
- Testing
- QPI-1002
- Where
- 36 sites in United States, Canada and 1 more
- Volunteers
- 341 people
- Sponsor
- Quark Pharmaceuticals
Complication of Extracorporeal Circulation, Complication of Coronary Artery Bypass Graft
Combined Use of a Novel Cardioplegic Formula With Myocardial Protection System (MPS)® Versus Cardioplexol ® in Isolated Coronary Artery Bypass Grafting (CABG) Using MiECC;
Combined use of a novel cardioplegic formula with MPS® (Myocardial protection system) versus Cardioplexol ® (colloid solution with Procaine, magnesium and potassium) in isolated CABG (coronary artery bypass grafting) using MiECC…
- Trial name
- MiECC (NCT03612388)
- Testing
- use of a cardioplegic formula in isolated CABG (coronary artery bypass grafting) using MiECC (Minimal extracorporeal circulation
- Where
- Switzerland
- Volunteers
- 211 people
- Sponsor
- University Hospital, Basel, Switzerland
Covid19, Heart Failure
Complications and the Influence of COVID-19 on Myocardial Function and Exercise Capacity
The subject of the study is the impact of COVID-19 on the indicators of myocardial efficiency and exercise capacity. As a result of the observed dependencies, it will be possible to start an appropriate diagnostic procedure…
- Trial name
- NCT04828629
- Testing
- Diagnostic tests
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Cardiac Disease, Cancer
Electronic Medical Records and Genomics (eMERGE) Phase III
The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes.
- Conditions
- Cardiac Disease, Cancer, Hypercholesterolemia, Diabetes
- Trial name
- eMERGE (NCT03394859)
- Volunteers
- 25,380 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Randomized Controlled Trial, Dexmedetomidine
Effect of Dexmedetomidine on Central Nervous System Complications in Patients Undergoing Cardiac Surgery
With the continuous improvement of medical technology, more and more patients need to undergo surgery as a kind of treatment for their diseases.
- Trial name
- NCT06551259
- Testing
- Dexmedetomidine, physiological saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Microdeletion Syndromes, Trisomy 21
Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA
The purpose of this study is to collect blood from families with a child who has been diagnosed with a chromosomal disorder including microdeletions in order to further develop a non-invasive prenatal screening test based on…
- Conditions
- Microdeletion Syndromes, Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- Microdel Triad (NCT02109770)
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- Natera, Inc.
Diabetes, Hypoglycaemia
Predicting Hypoglycaemia and Arrhythmias in the Patient With Diabetes and CKD - Validation Study
Patients with insulin-dependent diabetes mellitus (DM) and chronic kidney disease (CKD) exhibit an excessive risk for cardiac arrhythmias, in particular sudden cardiac death (SCD).
- Conditions
- Diabetes, Hypoglycaemia, Chronic Kidney Disease
- Trial name
- HypoArrhythmia (NCT02778269)
- Testing
- 12-lead ECG T-shirt, Dexcom G4-System
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Acute Kidney Injury
Renal Replacement Therapy and In-Hospital Mortality Incidence in Cardiac Surgery Associated Acute Kidney Injury
The goal of this study is to analyse the relation of severe acute kidney injury post cardiac surgery which characterised by the need of renal replacement therapy, with in-hospital postoperative mortality incidence.
- Trial name
- NCT06091982
- Testing
- Renal Replacement Therapy (RRT)
- Where
- Indonesia
- Volunteers
- 1,113 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Disorder of Vitamin C, Atrial Fibrillation
High Dose Vitamin C in Cardiac Surgery Patients
Coronary artery bypass grafting (CABG) is the most common procedure performed by cardiac surgeons. Post-operative atrial fibrillation (AF) is the most common adverse event following CABG, experienced in 20-50% of patients; the…
- Conditions
- Disorder of Vitamin C, Atrial Fibrillation, Complications Due to Coronary Artery Bypass Graft, Heart Valve Disease
- Trial name
- NCT02762331
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Virginia Commonwealth University
Type 2 Diabetes, High Blood Pressure
Polypill for Prevention of Cardiomyopathy
This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score.
- Trial name
- PolyPreventHF (NCT06143566)
- Testing
- Polypill, Combined prescription of the individual medications
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
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